Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nobuyuki, Hirohashi"'
Autor:
Masanori Abe, Hidetoshi Shiga, Hiroomi Tatsumi, Yoshihiro Endo, Yoshihiko Kikuchi, Yasushi Suzuki, Kent Doi, Taka-Aki Nakada, Hiroyuki Nagafuchi, Noriyuki Hattori, Nobuyuki Hirohashi, Takeshi Moriguchi, Osamu Yamaga, Osamu Nishida
Publikováno v:
Renal Replacement Therapy, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Background The Japan Society for Blood Purification in Critical Care (JSBPCC) has reported survey results on blood purification therapy (BPT) for critically ill patients in 2005, 2009, and 2013. To clarify the current clinical status, includ
Externí odkaz:
https://doaj.org/article/c9b6fc92bd664822b133c03d49959a12
Autor:
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is gene
Externí odkaz:
https://doaj.org/article/cadfc18f87f14c8381e5f00ac64ea3be
Autor:
Maryami Yuliana Kosim, Takahiro Fukazawa, Mutsumi Miyauchi, Nobuyuki Hirohashi, Keiji Tanimoto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Lactoferrin (LF) is an iron binding glycoprotein of the transferrin family with a wide spectrum of biological effects, including anti-cancer activity. However, the detailed molecular mechanisms of anti-cancer activity of LF have not been fully determ
Externí odkaz:
https://doaj.org/article/2d61e3fb5b094dd2856fbbbdc1ceeb18
Autor:
Kiichi Shimabukuro, Takahiro Fukazawa, Akinori Kanai, Hidehiko Kawai, Kengo Mekata, Nobuyuki Hirohashi, Naoya Kakimoto, Keiji Tanimoto
Publikováno v:
Cells, Vol 11, Iss 3, p 501 (2022)
The biological effects of low-dose-rate (LDR) radiation exposure in nuclear power plant accidents and medical uses of ionizing radiation (IR), although being a social concern, remain unclear. In this study, we evaluated the effects of LDR-IR on globa
Externí odkaz:
https://doaj.org/article/74d507214f714bd095df23a352617082
Autor:
Takahiro Fukazawa, Keiji Tanimoto, Looniva Shrestha, Takeshi Imura, Shinya Takahashi, Taijiro Sueda, Nobuyuki Hirohashi, Eiso Hiyama, Louis Yuge
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219363 (2019)
Although the biological systems in the human body are affected by the earth's gravity, information about the underlying molecular mechanisms is limited. For example, apoptotic signaling is enhanced in cancer cells subjected to microgravity. We reason
Externí odkaz:
https://doaj.org/article/d625784dd4ff4af7a18eaa9388ee9b81
Autor:
Hideaki Nakamura, Hidemasa Bono, Keiko Hiyama, Takeshi Kawamoto, Yukio Kato, Takeshi Nakanishi, Masahiko Nishiyama, Eiso Hiyama, Nobuyuki Hirohashi, Eisaburo Sueoka, Lorenz Poellinger, Keiji Tanimoto
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192136 (2018)
Tumor hypoxia contributes to a biologically aggressive phenotype and therapeutic resistance. Recent studies have revealed that hypoxia reduces expression of several DNA damage recognition and repair (DRR) genes via both hypoxia-inducible factor (HIF)
Externí odkaz:
https://doaj.org/article/53c23c09bc844f229fe5bf4c913f05b2
Autor:
Takahiro Fukazawa, Keiji Tanimoto, Emi Yamaoka, Masato Kojima, Masami Kanawa, Nobuyuki Hirohashi, Eiso Hiyama
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4732
Outcomes of pediatric hepatoblastoma (HBL) have improved, but refractory cases still occur. More effective and safer drugs are needed that are based on molecular mechanisms. A disintegrin and metalloproteases (ADAMs) are expressed with high frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22809fd7757d247aafd84935459284e4
Autor:
Hidemasa Bono, Nobuyuki Hirohashi, Keiji Tanimoto, Akinori Kanai, Hideaki Nakamura, Hidetaka Eguchi, Hiromasa Ono, Takahiro Fukazawa, Kazumi Shimamoto
Publikováno v:
Carcinogenesis. 41:1184-1194
We previously demonstrated that expression of a Krüppel-like zinc finger transcription factor, GLIS1, dramatically increases under hypoxic conditions via a transcriptional mechanism induced by HIF-2α cooperating with AP-1 members. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e310cd1e09aefbb35c5051b4891502c
https://doi.org/10.1093/carcin/bgaa010
https://doi.org/10.1093/carcin/bgaa010
Autor:
Toshihito Nomura, Takahiro Fukazawa, Hidemasa Bono, Takemasa Sakaguchi, Nobuyuki Hirohashi, Nazmul Tanuza, Kiichi Hirota, Yoshiyuki Matsuo, Keiji Tanimoto
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is generally bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2f7bd8ff7f8e4b5f8d9e93f814d2d4
https://doi.org/10.1038/s41598-021-96109-w
https://doi.org/10.1038/s41598-021-96109-w
Autor:
Takemasa Sakakuchi, Keiji Tanimoto, Hidemasa Bono, Nazmul Tanuza, Toshihito Nomura, Yoshiyuki Matsuo, Kiichi Hirota, Nobuyuki Hirohashi, Takahiro Fukazawa
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2. Although cigarette smoke is generally bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e6330f493145479e36c3936453e0fa
https://doi.org/10.1101/2021.03.04.433658
https://doi.org/10.1101/2021.03.04.433658
