Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nobuyoshi Tajima"'
Publikováno v:
Chirality. 32:223-230
24S-hydroxycholesterol (HC) is most abundant oxysterols in the brain, passes through blood brain barrier, and is therefore regarded as an intermediary for brain cholesterol elimination. We reported that large-conductance Ca2+ - and voltage-activated
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:1525-1535
Oxysterols, oxidization products of cholesterol, are regarded as bioactive lipids affecting various physiological functions. However, little is known of their effects on ion channels. Using inside-out patch clamp recording, we found that naturally oc
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1864(10)
Oxysterols, oxidization products of cholesterol, are regarded as bioactive lipids affecting various physiological functions. However, little is known of their effects on ion channels. Using inside-out patch clamp recording, we found that naturally oc
Autor:
Min Wang, Xiaoyan Liu, Yuan Shui, Hideaki Iizuka, Jingyu Zou, Nobuo Kato, Nobuyoshi Tajima, Yasuhito Ishigaki, Takuya Akai, Osamu Uchiumi
Publikováno v:
Brain Research. 1637:56-63
Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning
Autor:
Toshinori Hoshi, Yutao Tian, Shangwei Hou, Michael Bauer, Stefan H. Heinemann, Nobuyoshi Tajima, Bianka Wissuwa, Rong Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 110:4816-4821
Long-chain polyunsaturated omega-3 fatty acids such as docosahexaenoic acid (DHA), found abundantly in oily fish, may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems. However, the mechanis
Autor:
Reijo Käkelä, Pentti Somerharju, Yutaka Itokazu, Nobuyoshi Tajima, Laura Kerosuo, Robert K. Yu, Hannu Sariola
Publikováno v:
Neurochemical research. 41(7)
The central nervous system (CNS) harbors multiple glial fibrillary acidic protein (GFAP) expressing cell types. In addition to the most abundant cell type of the CNS, the astrocytes, various stem cells and progenitor cells also contain GFAP+ populati
Autor:
Pavithra Lakshminarasimhan, Keiko Funa, Muna Elmi, Shin-Ichi Nishikawa, Akiyoshi Uemura, Hans Ågren, Nobuyoshi Tajima, Weiwen Yang, Zhao-jun Zeng, Alicia Moshiri, Yoshiki Matsumoto
Publikováno v:
Molecular and Cellular Neuroscience. 45:121-131
The orphan nuclear receptor TLX has been proposed to act as a repressor of cell cycle inhibitors to maintain the neural stem cells in an undifferentiated state, and prevents commitment into astrocyte lineages. However, little is known about the mecha
Autor:
Stefan H. Heinemann, Martin Kaatz, Kristina Schönherr, Roland Schönherr, Nobuyoshi Tajima, Hiroshi Kanno, Susanna Niedling
Publikováno v:
The Journal of Physiology. 571:349-359
Under chronic hypoxia, tumour cells undergo adaptive changes involving hypoxia-inducible factors (HIFs). Here we report that ion currents mediated by Ca2+-activated K+ (KCa) channels in human melanoma IGR1 cells are increased by chronic hypoxia (3% O
Autor:
Mari Dezawa, Hiroshi Kanno, Mikio Hoshino, Hirotomi Cho, Naoya Matsumoto, Yutaka Itokazu, Nobuyoshi Tajima, Hitoshi Yamada, Hajime Sawada, Hiroto Ishikawa, Toshirou Mimura, Masaaki Kitada, Yoshihisa Suzuki, Chizuka Ide
Publikováno v:
Journal of Clinical Investigation. 113:1701-1710
Bone marrow stromal cells (MSCs) have the capability under specific conditions of differentiating into various cell types such as osteocytes, chondrocytes, and adipocytes. Here we demonstrate a highly efficient and specific induction of cells with ne
Autor:
Katuyoshi Shimamura, Nobuyoshi Tajima, Jun Funazaki, Hirobumi Suzuki, Etsuo Shinohara, Kenji Sakano, Hidesaburo Kobayashi, Tomohiko Akaida
Publikováno v:
Journal of Chromatography A. 990:169-178
Continuous free flow electrophoresis of proteins was carried out in a microfabricated free flow electrophoresis (mFFE) module with the 30-μm thick slit of the separation. The newly developed micromodule fraction separator (MFS) was attached to the d