Výsledky vyhledávání - "Nobuyoshi Sumi"

SINGLE-DOSE TOXICITY STUDIES OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN MICE, RATS AND DOGS

Autor: Motokuni Nakazawa, Yasuyuki Nishiguchi, Takaaki Oka, Masaru Yoshida, Nobuyoshi Sumi, Keiko Wakura, Mutsumi Tarui

Publikováno v: The Journal of Toxicological Sciences. 22:1-13

Comparative single-dose toxicity studies of (±)-4-diethylamino-1, 1-dimethylbut-2-yn- 1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate(NS-21), a new drug for the treatment of urinary frequency and incontinence, were conducte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf812bc79417b8a522ff8c18a4d1faf8
https://doi.org/10.2131/jts.22.supplementi_1

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ORAL SINGLE-DOSE AND 13-WEEK REPEAT-DOSE TOXICITY STUDIES OF RCC-36, THE ACTIVE METABOLITE OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONO-HYDROCHLORIDE MONOHYDRATE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN RATS

Autor: Tsukao Nishimori, Nobuyoshi Sumi, Shigenori Furukawa, Seitaro Ishibashi, Yuzou Taniguchi, Hachiro Kouyama, Keiko Wakura, Mikito Kikumori

Publikováno v: The Journal of Toxicological Sciences. 22:93-124

Oral single-dose and 13-week repeat-dose toxicity studies of (+/-)-4-ethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride (RCC-36), an active metabolite of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916fb0f3dc122451c6489939fde3e690
https://doi.org/10.2131/jts.22.supplementi_93

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SINGLE-DOSE TOXICITY STUDIES OF PRULIFLOXACIN (NM441) IN MICE, RATS AND DOGS AND THE ACTIVE METABOLITE (NM394) IN RATS

Autor: Nobuyoshi Sumi, Yuji Ishikawa, Keiko Iwakura, Hiroshi Shimazu, Yasuyuki Nishiguchi, Masaru Yoshida, Yasuhiro Shindo

Publikováno v: The Journal of Toxicological Sciences. 21:33-44

Single-dose toxicity studies of prulifloxacin, a new antibacterial agent, were conducted in mice, rats and dogs. In addition, a single-dose toxicity study of (+/-)-6-fluoro-1-methyl-4-oxo-7- (1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline- 3-carboxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b000961c9fc443e66cf5cd401b1fb2
https://doi.org/10.2131/jts.21.supplementi_33

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REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF PRULIFLOXACIN (NM441) (2) : A Teratogenicity Study in Rats by Oral Administration

Autor: Tagahiko Morinaga, Kimio Yasuhira, Masataka Watanabe, Yasuhiro Shindo, Nobuyoshi Sumi, Shigenori Furukawa, Shigenobu Fujii, Mikito Kikumori

Publikováno v: The Journal of Toxicological Sciences. 21:187-206

A study of the effect of prulifloxacin, a new antibacterial agent, during the period of organogenesis was conducted in Sprague-Dawley rats. Female rats were given prulifloxacin orally at dose levels of 0 (control), 30, 300, and 3000 mg/kg from day 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558d77f1659d23e67a5a11e095c7d30c
https://doi.org/10.2131/jts.21.supplementi_187

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SINGLE AND 4-WEEK ORAL TOXICITY STUDIES OF PRULIFLOXACIN (NM441) IN AGED DOGS

Autor: Toshio Ihara, Nobuyoshi Sumi, Ryoichi Nagata, Yutaka Chihaya, Asaoka H, Yasuhiro Shindo, Atsushi Akune, Kazuhiro Nakama

Publikováno v: The Journal of Toxicological Sciences. 21:149-169

Single-dose and repeated dose toxicity studies of prulifloxacin, a new antibacterial agent, were conducted in aged beagle dogs. I. A single-dose toxicity study Prulifloxacin was administered orally to aged female dogs at a single dose of 2500 and 500

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4f780bb256dfd99f14eb8cf2dc9474
https://doi.org/10.2131/jts.21.supplementi_149

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A 4-WEEK INTRAVENOUS TOXICITY STUDY OF THE ACTIVE METABOLITE (NM394) OF PRULIFLOXACIN (NM441) IN RATS FOLLOWED BY A 4-WEEK RECOVERY TEST

Autor: Keiko Iwakura, Shigeru Ishida, Yasuhiro Shindo, Susumu Yamazaki, Kazutoshi Tamura, Masamichi Iketani, Nobuyoshi Sumi

Publikováno v: The Journal of Toxicological Sciences. 21:131-148

A repeated dose toxicity study of ( +/- )-6- fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (NM394), the active metabolite of a new antibacterial agent, prulifloxacin, was conducted in Sprague-Dawley rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d45012eeca54cbe780138af9504407
https://doi.org/10.2131/jts.21.supplementi_131

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RENAL TOXICITY OF PRULIFLOXACIN (NM441) IN RATS

Autor: Takeharu Tawaratani, Akitaka Kawaminami, Keiko Iwakura, Shinji Matsuyama, Seitaro Ishibashi, Kazuo Kakemi, Takaaki Oka, Yasuhiro Shindo, Nobuyoshi Sumi

Publikováno v: The Journal of Toxicological Sciences. 21:267-276

Renal toxicity of prulifloxacin, a new antibacterial agent, was investigated in rats of both sexes. The animals were given prulifloxacin orally for 28 days at a dose of 3000 mg/kg. Tubular nephrosis in which crystalline substances appeared primarily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bacde943fc12be16cf0eb0965cf0b08
https://doi.org/10.2131/jts.21.supplementi_267

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MUTAGENICITY STUDIES OF PRULIFLOXACIN (NM441) AND THE ACTIVE METABOLITE (NM394)

Autor: Yasuhiro Shindo, Makoto Ando, Keiko Iwakura, Motoyoshi Kojima, Masataka Watanabe, Nobuyoshi Sumi, Yasuhiro Yamashita, Hironobu Tamura

Publikováno v: The Journal of Toxicological Sciences. 21:241-257

The mutagenicity of prulifloxacin, a new antibacterial agent, was investigated by the reverse mutation test in bacteria, the chromosomal aberration test in cultured cells, and the micronucleus test in mice. In addition, NM394, an active metabolite of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e19af1d3e5ae1bbaeca694127569e2
https://doi.org/10.2131/jts.21.supplementi_241

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REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF PRULIFLOXACIN (NM441) (3) : A teratogenicity Study in Rabbits by Oral Administration

Autor: Tagahiko Morinaga, Shigenobu Fujii, Kimio Yasuhira, Mikito Kikumori, Yasuhiro Shindo, Masataka Watanabe, Shigenori Furukawa, Nobuyoshi Sumi

Publikováno v: The Journal of Toxicological Sciences. 21:207-217

A study of the effect of prulifloxacin, a new antibacterial agent, during the period of organogenesis was conducted in New Zealand White rabbits. Female rabbits were given prulifloxacin orally at dose levels of 0 (control), 10, 30 and 100 mg/kg from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e297fd6d57e4ae3298fe795760ee3fb0
https://doi.org/10.2131/jts.21.supplementi_207

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A PHOTOALLERGENICITY STUDY OF PRULIFLOXACIN (NM441) IN GUINEA PIGS

Autor: Katsumasa Ishimura, Nobuyoshi Sumi, Asaoka H, Tatsumi Inoue, Kouhachi Kamata, Yasuhiro Shindo, Mikako Ishihara, Akihiko Ogawa

Publikováno v: The Journal of Toxicological Sciences. 21:259-265

Photoallergenicity of prulifloxacin, a new antibacterial agent, was examined using guinea pigs compared with those of the other quinolone antibacterial drugs, ofloxacin (OFLX), lomefloxacin (LFLX), ciprofloxacin (CPFX), enoxacin (ENX) and nalidixic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f518a3301148f0fa88e0aeae39b39d9
https://doi.org/10.2131/jts.21.supplementi_259

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