Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nobuyoshi Amishiro"'
Autor:
Yoji Ino, Yoshihisa Ohta, Tetsuya Tsujita, Seiho Okamoto, Ryuichiro Nakai, Nobuyoshi Amishiro, Takeshi Takahashi, Kazuhiko Kato, Yoshinori Yamashita, Junichiro Yamamoto, Shiro Akinaga, Hideaki Kusaka, Mitsuharu Araki, Chikara Murakata
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(16)
The 2,4,5-substituted-1,3,4-thiadiazoline derivative 1a has been identified as a new class of mitotic kinesin Eg5 inhibitor. With the aim of enhancement of the mitotic phase accumulation activity, structure optimization of side chains at the 2-, 4-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aa67a01233fbd9989dafe59dc7bb8b
https://pubmed.ncbi.nlm.nih.gov/25001485
https://pubmed.ncbi.nlm.nih.gov/25001485
Autor:
Satoru Nagamura, Eiji Kobayashi, Masami Okabe, Katsushige Gomi, Akihiko Okamoto, Hiromitsu Saito, Nobuyoshi Amishiro
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:1637-1643
A series of A-ring pyrrole derivatives of duocarmycin bearing β-(5′,6′,7′-trimethoxy-2′-indolyl)acryloyl group were synthesized, and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f0decc5a50701db5bd611e1b321120
https://doi.org/10.1016/s0968-0896(00)00086-9
https://doi.org/10.1016/s0968-0896(00)00086-9
Publikováno v:
Journal of Medicinal Chemistry. 42:669-676
A series of A-ring pyrrole compounds of duocarmycin bearing 4'-methoxy-beta-heteroarylacryloyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e5bd1cf92318aecfe695d9e82ce997
https://doi.org/10.1021/jm980559y
https://doi.org/10.1021/jm980559y
Autor:
Eiji Kobayashi, Hiromitsu Saito, Nobuyoshi Amishiro, Akihiko Okamoto, Satoru Nagamura, Katsushige Gomi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1393-1403
A series of A-ring pyrrole compounds of duocarmycin bearing 5-membered heteroarylacryloyl groups (thienylacryloyl and pyrrolylacryloyl) and heteroarylcarbonyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a2e8a23c30d14f910159bad4c19444
https://doi.org/10.1248/cpb.47.1393
https://doi.org/10.1248/cpb.47.1393
Autor:
Nobuyoshi Amishiro, Katsushige Gomi, Akira Asai, Satoru Nagamura, Eiji Kobayashi, Hiromitsu Saito
Publikováno v:
Journal of Medicinal Chemistry. 40:972-979
A series of N-cinnamates of the A-ring pyrrole compound of duocarmycin were synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in mice. The 4‘-methoxy- and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d632006561fb829e620f259a26a6d88a
https://doi.org/10.1021/jm9606094
https://doi.org/10.1021/jm9606094
Autor:
Eiji Kobayashi, Satoru Nagamura, Nobuyoshi Amishiro, Akihiko Okamoto, Katsushige Gomi, Hiromitsu Saito
Publikováno v:
ChemInform. 31
A series of A-ring pyrrole compounds of duocarmycin bearing 5-membered heteroarylacryloyl groups (thienylacryloyl and pyrrolylacryloyl) and heteroarylcarbonyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406fc274ed1b10968d596aea846ef9ae
https://doi.org/10.1002/chin.200013209
https://doi.org/10.1002/chin.200013209
Autor:
Scott E. Denmark, Nobuyoshi Amishiro
Publikováno v:
ChemInform. 35
The addition of aryltrialkoxysilanes to alpha,beta-unsaturated carbonyl compounds (ketones, aldehydes) and nitroalkenes in the presence of SbCl(3), TBAF, AcOH, and a catalytic amount of Pd(OAc)(2), in CH(3)CN at 60 degrees C, provides the correspondi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0367635cd01810ff1f9efbac9a58216c
https://doi.org/10.1002/chin.200403045
https://doi.org/10.1002/chin.200403045
Autor:
Tadakazu Akiyama, Yukimasa Shiotsu, Yoji Ikuina, Harumi Ogawa, Shiro Akinaga, Mayumi Miyata, Nobuyoshi Amishiro, Chikara Murakata, Hiroaki Narumi
Publikováno v:
Journal of medicinal chemistry. 46(12)
Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the inhibition or degradation of Hsp90-associated proteins, such as v-src and Raf-1 kinases. New O-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e6b740aa884411b4c709a0222360a
https://pubmed.ncbi.nlm.nih.gov/12773056
https://pubmed.ncbi.nlm.nih.gov/12773056
Publikováno v:
Bioorganicmedicinal chemistry. 8(5)
A series of the C7-substituted A-ring pyrrole derivatives of duocarmycin were synthesized, and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in mice. All of the C7-substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e264ab0f6741b97fc6989a676adc41
https://pubmed.ncbi.nlm.nih.gov/10882029
https://pubmed.ncbi.nlm.nih.gov/10882029
Autor:
Akihiko Okamoto, Satoru Nagamura, Nobuyoshi Amishiro, Kazuo Yamaguchi, Katsushige Gomi, Masao Asada, Hiromitsu Saito, Tatsuya Tamaoki, Eiji Kobayashi, Chikara Murakata, Naoko Yamaguchi, Masami Okabe
Publikováno v:
Bioorganicmedicinal chemistry. 8(2)
A series of the 8-O-substituted A-ring pyrrole derivatives of duocarmycin bearing the simplified DNA-binding moieties such as cinnamoyl or heteroarylacryloyl groups were synthesized, and evaluated for in vitro anticellular activity against HeLa S3 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563f1ddd7f76c2f95a85e074d2180abc
https://pubmed.ncbi.nlm.nih.gov/10722161
https://pubmed.ncbi.nlm.nih.gov/10722161