Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nobuyasu Komeshima"'
Autor:
Masayuki Sakakibara, Kuniaki Tatsuta, Hiroyuki Kawai, Shohachi Nakajima, Hamao Umezawa, Noboru Otake, Nobuyasu Komeshima
Publikováno v:
The Journal of Antibiotics. 45:374-379
4'-O-Acyl derivatives of doxorubicin, daunorubicin, 13-deoxocarminomycin, 13-deoxo-10-hydroxycarminomycin, 13-deoxo-11-deoxycarminomycin were synthesized through the formation and mild acid hydrolysis of 2-oxazoline intermediates. The antitumor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993efa5ed37e44b6c179b26e0612eb58
https://doi.org/10.7164/antibiotics.45.374
https://doi.org/10.7164/antibiotics.45.374
Autor:
Shigeru Tsukagoshi, Takashi Tsuruo, Kenji Koga, Tazuko Tashiro, Hidemichi Mizuguchi, Seiichi Tanida, Toyokazu Kishi, Tsuneo Ishiguro, Kiyoshi Tomioka, Nobuyasu Komeshima
Publikováno v:
Journal of Medicinal Chemistry. 34:54-57
The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da999305f91f7a7fa2bf69f9f50d9012
https://doi.org/10.1021/jm00105a009
https://doi.org/10.1021/jm00105a009
Publikováno v:
Chemical and Pharmaceutical Bulletin. 27:2437-2441
The Michael reaction of diethyl malonate with chiral α, β-unsaturated aldimines (4), prepared from crotonaldehyde and optically active α-amino acid tert-butyl esters (3), was found to give the corresponding β-substituted aldehydes (5) in reasonab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aa563a7b6321bba651750ab60697932
https://doi.org/10.1248/cpb.27.2437
https://doi.org/10.1248/cpb.27.2437
Autor:
Nobuo Ikota, Kiyoshi Tomioka, Shunichi Hashimoto, Kenji Koga, Ichiro Takahashi, Nobuyasu Komeshima, Hiroyuki Takemura
Publikováno v:
Tetrahedron Letters. 28:5687-5690
Clear stereochemical relationships were observed between the structure of chiral sources of catalysts and absolute configuration of the Diels-Alder adducts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fadc05b15b9947a1e9c4974e66c1eb82
https://doi.org/10.1016/s0040-4039(00)96814-x
https://doi.org/10.1016/s0040-4039(00)96814-x
Autor:
Nobuyasu Komeshima, Hlroyuki Kawai, Tomio Takeuchi, Masahiko Watanabe, Noboru Otake, Shohachi Nakajima, Takashi Tsuruo
Publikováno v:
The Journal of Antibiotics. 42:1424-1429
3'-Deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2), a morpholino anthracycline derived from 13-deoxo-10-hydroxycarminomycin (R20X2) was 16 times less cytotoxic than R20X2 against cultured P388 leukemia cells. The reduced cytotoxicity of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b318404d2047c1500ee64e588a406f
https://doi.org/10.7164/antibiotics.42.1424
https://doi.org/10.7164/antibiotics.42.1424
Publikováno v:
The Journal of Antibiotics. 41:548-553
Antitumor activity of 3'-deamino-3'-morpholino anthracyclines was examined. Morpholino derivatives of 13-deoxocarminomycins, MX2 (1), MX (2) and MY5 (3) shown in Fig. 1, administered iv showed increase in life span (ILS) values over 110% against ip-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fca3303b9daa19c669e590f1684d8ed
https://doi.org/10.7164/antibiotics.41.548
https://doi.org/10.7164/antibiotics.41.548
Publikováno v:
The Journal of Antibiotics. 40:1349-1352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c95f09a5eb628fd0099d34f81fb9e8
https://doi.org/10.7164/antibiotics.40.1349
https://doi.org/10.7164/antibiotics.40.1349
Autor:
Haruo Seto, Yoichi Hayakawa, Akihiro Shimosaka, Noboru Otake, Masaya Nakagawa, Hiroyuki Kawai, Nobuyasu Komeshima
Publikováno v:
The Journal of antibiotics. 40(9)
Biological activities of arugomycin and its analogues obtained by chemical degradation and modification were evaluated. Differences in the sugar moieties affected their biological activities including induction of differentiation of mouse Friend eryt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ff5e69d43445cffb76cc6a733a6d08
https://pubmed.ncbi.nlm.nih.gov/3479414
https://pubmed.ncbi.nlm.nih.gov/3479414
Autor:
Shunichi Hashimoto, Nobuyasu Komeshima, Kiyoshi Tomioka, Hiroyuki Takemura, Nobuo Ikota, Ichiro Takahashi, Kenji Koga
Publikováno v:
ChemInform. 19
Clear stereochemical relationships were observed between the structure of chiral sources of catalysts and absolute configuration of the Diels-Alder adducts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b063e2332718bc46ccc01c7d79aa588
https://doi.org/10.1002/chin.198818153
https://doi.org/10.1002/chin.198818153
Publikováno v:
J. Chem. Soc., Chem. Commun.. :437-438
Evidence is presented that considerable asymmetric induction can occur in Diels–Alder reactions catalysed by chiral alkoxyaluminium dichlorides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b82433b80f737fa4a77170ba190d0d0f
https://doi.org/10.1039/c39790000437
https://doi.org/10.1039/c39790000437