Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Nobuya Kawauchi"'
1
Synthesis and pharmacological studies of N-substituted 6-[(2-aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinediones, novel class III antiarrhythmic agents
Autor: Tsutomu Katakami, Joji Kamiya, Nobuya Kawauchi, Tadahito Nobori, Tatsuo Kaiho, Haruki Mori, Michihiko Miyamoto, Kunio Sannohe, Tatsuro Yokoyama
Publikováno v: Journal of Medicinal Chemistry. 35:3325-3330
A series of 6-[(2-aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)- pyrimidinedione derivatives were synthesized and studied for their class III electrophysiological activity and class II (beta-blocking) effects in in vitro and in vivo models. Structure-act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494840e2071ca6c937ab00f7b055fc46
https://doi.org/10.1021/jm00096a003
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2
Evaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases
Autor: Ai-Hua Lu, Ole Hindsgaul, Monica Palcic, Kenji Osumi, Nobuya Kawauchi
Publikováno v: Nucleic acids symposium series. (44)
The inhibition of glycosyltrans ferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e9a9062cb28ff3adab4178e78aef33
https://pubmed.ncbi.nlm.nih.gov/12903282
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4
Synthesis of 2,3-anhydro- and 3,4-anhydro-hexopyranosides having a methyl branch on the oxirane ring, and their reactions with some lithium methylcuprate reagents
Autor: Hironobu Hashimoto, Toshio Yasumori, Nobuya Kawauchi, Ken-ichi Sato, Juji Yoshimura
Publikováno v: Carbohydrate Research. 133:255-274
Three 2,3-anhydroaldohexopyranosides having a 2-C-methyl or 3-C-methyl branch, as well as three 3,4-anhydroaldohexopyranosides having a 3-C-methyl (7) or 4-C-methyl branch, were newly synthesized. The reactions of these, together with those of a know
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a58888d9189b883402cbdbcd89dea34
https://doi.org/10.1016/0008-6215(84)85203-9
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7
Oxidative Cleavage of 4,6-O-Benzylidene Ring with t-Butyl Hydroperoxide and Copper(II) Chloride. Preparation of Methyl 4-O- and 6-O-Benzoylhexopyranoside Derivatives
Autor: Ken-ichi Sato, Yukio Yanagisawa, Hironobu Hashimoto, Nobuya Kawauchi, Tetsutaro Igarashi, Juji Yoshimura
Publikováno v: Chemistry Letters. 17:1699-1702
Copper(II) chloride and palladium(II) acetate were found to be highly effective catalysts for oxidative cleavage of O-benzylidene ring with t-butyl hydroperoxide. Using the former catalyst 4,6-O-benzylidenehexopyranoside derivatives were converted in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d080534c7f34dbb2b99a45f579d5b1
https://doi.org/10.1246/cl.1988.1699
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8
Synthesis of 2,2-Di-C-methyl-2-deoxy- and 4,4-Di-C-methyl-4-deoxypyranosides via Michael Addition of Conjugated Enopyranosiduloses
Autor: Ken-ichi Sato, Hironobu Hashimoto, Nobuya Kawauchi, Juji Yoshimura
Publikováno v: Bulletin of the Chemical Society of Japan. 60:1433-1439
Three hexopyranosides having gem-di-C-methyl group at 2- or 4-positions were synthesized by Michael addition to 2-enopyranosid-4-ulose and 3-enopyranosid-2-ulose derivatives, respectively, followed by hydroboration. A heptopyranosid-6-ulose having ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c42c39c91387ec993de8823e41d560e
https://doi.org/10.1246/bcsj.60.1433
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9
Reaction of Enohexopyranoside Acetates with Lithium Dimethylcuprate(I) and Its Application to Synthesis of Prelog-Djerassi Lactone
Autor: Hironobu Hashimoto, Nobuya Kawauchi
Publikováno v: Bulletin of the Chemical Society of Japan. 60:1441-1447
In the reaction of two 2-O-acetyl-3-enohexopyranosides and four 4-O-acetyl-2-enohexopyranosides including 2-C-methyl and 4-C-methyl derivatives, respectively, with lithium dimethylcuprate(I), anti SN2′ substitution was proved to be preferential, gi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a59f8b82b5938f4d39f783549c324ea
https://doi.org/10.1246/bcsj.60.1441
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10
TWO COMPLEMENTARY METHODS FOR INTRODUCTION OFgem-DIMETHYL GROUP IN HEXOPYRANOSIDE RING
Autor: Hironobu Hashimoto, Nobuya Kawauchi, Juji Yoshimura
Publikováno v: Chemistry Letters. 14:965-968
Hexopyranosides having a gem-dimethyl group in the pyranose ring were synthesized By reductive cleavage of spiro-cyclopropane derivatives and By addition of methyl cuprates to methyl-branched enolone derivatives.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606b907f7a8c131efbbe75fe532cc2bc
https://doi.org/10.1246/cl.1985.965
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