Výsledky vyhledávání - "Nobuya, Yamaguchi"

Induction of tumor regression by administration of B7-Ig fusion proteins: mediation by type 2 CD8+ T cells and dependence on IL-4 production

Autor: Shiro Ono, Mikihiko Kogo, Nobuya Yamaguchi, Noritami Takeuchi, Xuyu Zhou, Shin-ichiro Hiraoka, Takao Mukai, Stanley Wolf, Vincent Ling, Kyriaki Dunussi-Joannopoulos, Hiromi Fujiwara

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 172(3)

CD28 signals contribute to either type 1 or type 2 T cell differentiation. Here, we show that administration of B7.2-Ig fusion proteins to tumor-bearing mice induces tumor regression by promoting the differentiation of antitumor type 2 CD8+ effector

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482123b151d3466ed1051998ca5f56b1
https://pubmed.ncbi.nlm.nih.gov/14734709

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A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses

Autor: Chigusa Nakajima, Masayuki Iwasaki, Michio Tomura, Yasuhiro Uekusa, Mitsuhiro Nakazawa, Nobuya Yamaguchi, Ping Gao, Toshiyuki Hamaoka, Takao Mukai, Noritame Takeuchi, Hiromi Fujiwara, Takahiro Tsujimura

Publikováno v: Journal of leukocyte biology. 72(5)

Interleukin (IL)-12 plays a central role in the initiation and regulation of T cell-mediated immune responses. The present study investigated how IL-12, endogenously produced during tumor vaccination, functions for anti-tumor immune responses. Mice w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa7119c79c3b87478797c9c1a290efa
https://pubmed.ncbi.nlm.nih.gov/12429708

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A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses

Autor: Ping Gao, Takao Mukai, Hiroshi Iwaki, Takahiro Tsujimura, Takeshi Imanishi, Yi Fu Yang, Nobuya Yamaguchi, Hiromi Fujiwara, Toshiyuki Hamaoka, Satoshi Obika, Shiro Ono

Publikováno v: European journal of immunology. 32(8)

The chemokine receptors CCR5 and CXCR3 have been implicated as playing a central role in directing a Th1 inflammatory response. Here, we investigated whether a synthetic CCR5 antagonist affects the process of T cell migration to sites of inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c677dda318a55dbf8f22a639b74894b1
https://pubmed.ncbi.nlm.nih.gov/12209624

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Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation

Autor: Chigusa, Nakajima, Takao, Mukai, Nobuya, Yamaguchi, Yasunari, Morimoto, Woong-Ryeon, Park, Masayuki, Iwasaki, Ping, Gao, Shiro, Ono, Hiromi, Fujiwara, Toshiyuki, Hamaoka

Publikováno v: European journal of immunology. 32(6)

The chemokine receptor CXCR3 has been shown to play a key role in the recruitment of T cells to sites of inflammation such as allografts. Here, we investigated which signals and conditions areresponsible for CXCR3 induction. CXCR3 was induced on T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::715890ba095519052675fcab70cf96a6
https://pubmed.ncbi.nlm.nih.gov/12115663

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A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice

Autor: Yasuhiro, Uekusa, Wen-Gong, Yu, Takao, Mukai, Ping, Gao, Nobuya, Yamaguchi, Masako, Murai, Kouji, Matsushima, Satoshi, Obika, Takeshi, Imanishi, Yuji, Higashibata, Shintaro, Nomura, Yukihiko, Kitamura, Hiromi, Fujiwara, Toshiyuki, Hamaoka

Publikováno v: Cancer research. 62(13)

Interleukin (IL) 12 treatment in the CSA1M and OV-HM, but not in Meth A tumor models,induces tumor regression that is associated with T-cell migration to tumor sites.Here, we investigated the role of the CC chemokine receptor (CCR)5 in T-cell migrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68bd5b44b5cc877beaeec55ddd5fcec2
https://pubmed.ncbi.nlm.nih.gov/12097285

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A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5

Autor: Toshiyuki Hamaoka, Chigusa Nakajima, Ping Gao, Masayuki Iwasaki, Michio Tomura, Hiromi Fujiwara, Yi-Fu Yang, Nobuya Yamaguchi, Takao Mukai

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 167(12)

IL-12 was recently shown to induce CCR5 on TCR-triggered mouse T cells. Considering that STAT4 is the most critical of IL-12 signaling molecules, this study investigated the role for STAT4 in the induction of CCR5 expression. IL-12R was induced by st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cc525f80913de37fc4a78b0fecdf58
https://pubmed.ncbi.nlm.nih.gov/11739505

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