Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Nobutoshi Murakami"'
Autor:
Akihito Miyoshi, Toshihiro Horii, Satoru Tamura, Tomikazu Kawano, Sawako Itagaki, Nobutoshi Murakami
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:784-790
Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection "hot-spots," medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a con
Publikováno v:
Journal of Natural Medicines. 74:702-709
Africa Trypanosomiasis remains a serious health problem, but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded. In search for trypanocidal principles from medicinal plants, we found MeOH extracts of Meliae
Autor:
Satoru, Tamura, Akihito, Miyoshi, Tomikazu, Kawano, Toshihiro, Horii, Sawako, Itagaki, Nobutoshi, Murakami
Publikováno v:
Chemicalpharmaceutical bulletin. 68(8)
Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection "hot-spots," medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a con
Publikováno v:
Journal of natural medicines. 74(4)
Africa Trypanosomiasis remains a serious health problem, but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded. In search for trypanocidal principles from medicinal plants, we found MeOH extracts of Meliae
Autor:
Teruaki Koitabashi, Tomikazu Kawano, Yasumasa Komoda, Yoshiharu Matsuura, Nobutoshi Murakami, Gang-Ming Yang, Satoru Tamura
Publikováno v:
Journal of natural medicines. 73(1)
The envelope proteins of the hepatitis C virus (HCV), E1 and E2, have been revealed to be essential for invasion of HCV. Thus, we were engaged in the search for the inhibitors against HCV invasion through the assay system using the model virus expres
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(20)
We found out 2′,3′-dihydroxypuberulin from South American medicinal plant, V. thapsus L., as a candidate of an anti-allergic lead which inhibits the expression of high-affinity receptor of IgE (FceRI) on the surface of mast cells. Furthermore, th
Autor:
Takayuki Iwata, Satoru Tamura, Eric R. O. Siwu, Sanae Shirotsuki, Yasuyoshi Watanabe, Chika Kageyama, Shunsuke Douke, Katsunori Tanaka, Hirotaka Onoe, Nobutoshi Murakami, Koichi Fukase, Satoshi Nozaki, Tsuyoshi Tahara
Publikováno v:
ACS Chemical Biology. 7:637-645
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial
Autor:
Nobutoshi Murakami, Satoru Tamura
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 69:393-402
Nuclear export signal (NES)-mediated export of MEK and Rev from the nucleus to the cytoplasm is revealed to be essential for proliferation of tumor cells and viral multiplication of HIV. In this context, we have been engaged in explore medicinal lead
Autor:
Nobutoshi Murakami, Ken Watanabe, Satoru Tamura, Hanae Takatsuki, Nobuyuki Kobayashi, Megumi Sonoda
Publikováno v:
Drug Discoveries & Therapeutics. 5:26-31
Many pathogenic viruses, such as the influenza virus and the Human Immunodeficiency Virus (HIV)-1, are a threat to humans, thus leading to thousands of deaths annually. The development of antiviral drugs is urgent, and it is an essential strategy for
Publikováno v:
Tetrahedron. 66:8476-8480
The first total synthesis of peumusolide A (1) has been achieved by combination of regio- and stereo-selective aluminum-mediated hydroiodination to 2-yn-1-ol and enantioselective reduction of 4-en-1-yn-3-one with the chiral oxazaborolidine as the key