Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Nobutoshi Ito"'
Autor:
Nobutaka Numoto, Yoshiaki Kawano, Hideo Okumura, Seiki Baba, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 954-962 (2021)
Cooperative oxygen binding of hemoglobin (Hb) has been studied for over half a century as a representative example of the allostericity of proteins. The most important problem remaining to be solved is the lack of structural information on the interm
Externí odkaz:
https://doaj.org/article/b92a6503a02148d989861646dc469146
Autor:
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD,
Externí odkaz:
https://doaj.org/article/fd80c0c5e83d4543afa38997ad8b886c
Autor:
Nobutaka Numoto, Seiko Onoda, Yoshiaki Kawano, Hideo Okumura, Seiki Baba, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito
Publikováno v:
Biophysics and Physicobiology, Vol 19 (2022)
Ever since the historic discovery of the cooperative oxygenation of its multiple subunits, hemoglobin (Hb) has been among the most exhaustively studied allosteric proteins. However, the lack of structural information on the intermediates between oxyg
Externí odkaz:
https://doaj.org/article/f5d65fbe517741b79d0c5e0d4190b9c5
Autor:
Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto, Nobutoshi Ito, Naoya Hirata, Yasunari Kanda, Michiyasu Ishizawa, Makoto Makishima, Hiroyuki Kagechika, Aya Tanatani
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 130 (2022)
1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3, 1] is an active form of vitamin D3 and regulates various biological phenomena, including calcium and phosphate homeostasis, bone metabolism, and immune response via binding to and activation of vitamin D rec
Externí odkaz:
https://doaj.org/article/b359ac1d26e946909bc654659990f0b5
Publikováno v:
Biophysics and Physicobiology, Vol 16 (2019)
Pin1 is a peptidyl-prolyl isomerase (PPIase) which catalyzes cis/trans isomerization of pS/pT-P bond. Its activity is related to various cellular functions including suppression of Alzheimer’s disease. A cysteine residue C113 is known to be importa
Externí odkaz:
https://doaj.org/article/3d6afd0ebb884ab7acd24a4c67ce5ad1
Autor:
Yuhi Hosoe, Nobutaka Numoto, Satomi Inaba, Shuhei Ogawa, Hisayuki Morii, Ryo Abe, Nobutoshi Ito, Masayuki Oda
Publikováno v:
Biophysics and Physicobiology, Vol 16 (2019)
Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein that plays a critical role in cellular signal transduction. It contains a central Src homology 2 (SH2) domain flanked by two Src homology 3 (SH3) domains. Binding of Grb2 SH2 to the
Externí odkaz:
https://doaj.org/article/cf2ab42e399a4db8a87d28b3481c4fc6
Autor:
Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of
Externí odkaz:
https://doaj.org/article/cc58fcf33b4145468837fef116260032
Autor:
Naoko Matsubara, Akihiro Imamura, Tatsuya Yonemizu, Chizuru Akatsu, Hongrui Yang, Akiharu Ueki, Natsuki Watanabe, Hajjaj Abdu-Allah, Nobutaka Numoto, Hiromu Takematsu, Shinobu Kitazume, Thomas F. Tedder, Jamey D. Marth, Nobutoshi Ito, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Takeshi Tsubata
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed in various immune cells and most of them carry signaling functions. High-affinity synthetic sialoside ligands have been developed for various Siglecs. Therapeutic potentials of t
Externí odkaz:
https://doaj.org/article/b295e45b1a9243a2b75066dfbe524004
Autor:
Hiroyuki Masuno, Teikichi Ikura, Daisuke Morizono, Isamu Orita, Sachiko Yamada, Masato Shimizu, Nobutoshi Ito
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2206-2213 (2013)
The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)].
Externí odkaz:
https://doaj.org/article/1b4f265830f348b5abd8c0698dd12d27
Autor:
Kunitake Higo, Teikichi Ikura, Masayuki Oda, Hisayuki Morii, Jun Takahashi, Ryo Abe, Nobutoshi Ito
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74482 (2013)
Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor recep
Externí odkaz:
https://doaj.org/article/80d8e7e84a41461aa9a0f8041fbc5118