Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nobutaka Oohata"'
Autor:
Satoshi Ueda, Nobutaka Oohata, Masato Yamada, Masayoshi Kinoshita, Masaru Tsuboi, Fumihiro Tanaka, Seiji Hashimoto, Yasuhiro Isogai, Motohiro Hino, Shiho Shimizu
Publikováno v:
Journal of Bioscience and Bioengineering. 112:409-414
Micafungin (FK463) is a widely used treatment for life-threatening, deep-seated fungal infections. It is an echinocandin-like lipopeptide derived from the chemical modification of deacylated FR901379, a type of lipopeptide antibiotic produced by Cole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d211df6579b4bf5e843902f1acc105d3
https://doi.org/10.1016/j.jbiosc.2011.06.002
https://doi.org/10.1016/j.jbiosc.2011.06.002
Publikováno v:
ChemInform. 42
Natural fermentation products have long been studied as attractive targets for drug discovery due to their amazing diverse, complex chemical structures and biological activities. As such, a number of revolutionary drugs developed from natural ferment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fe1c18a5522134ac3c805f6a5e529a
https://doi.org/10.1002/chin.201114267
https://doi.org/10.1002/chin.201114267
Autor:
Yasuhiro Isogai, Katsuhiko Ito, Motohiro Hino, Nobutaka Oohata, Seiji Hashimoto, Takashi Shibata, Michio Yamashita, Masato Yamada, Satoshi Ueda
Publikováno v:
The Journal of antibiotics. 64(2)
FR901379 acylase, an enzyme that catalyzes the hydrolysis of the palmitoyl moiety of the antifungal lipopeptide FR901379, was purified from the culture broth of Streptomyces sp. no. 6907 (FERM BP-5809), revealing the 80 kDa, two-subunit heterodimeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397b2515674ef23a137694c87456524d
https://pubmed.ncbi.nlm.nih.gov/21119679
https://pubmed.ncbi.nlm.nih.gov/21119679
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 130(11)
Natural fermentation products have long been studied as attractive targets for drug discovery due to their amazing diverse, complex chemical structures and biological activities. As such, a number of revolutionary drugs developed from natural ferment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323022278031785cc96205cd9cb8f5c0
https://pubmed.ncbi.nlm.nih.gov/21048405
https://pubmed.ncbi.nlm.nih.gov/21048405
Autor:
Shigehiro Takase, Yasuhiro Hori, Yukiko Yamagishi, Takashi Fujita, Masakuni Okuhara, H. Terano, Nobutaka Oohata, Michio Yamashita
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ad46816cf52a638407e176f780a20f
https://doi.org/10.1002/chin.199605272
https://doi.org/10.1002/chin.199605272
Autor:
Y. Naoe, Sanae Matsumoto, Nobutaka Oohata, Ikuo Kawamura, Kyoichi Shimomura, Susumu Tsujimoto, E. Lacey, Toshitaka Manda, Fusako Nishigaki
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcae8817cbae050a9a30456910767790
https://doi.org/10.1002/chin.199604269
https://doi.org/10.1002/chin.199604269
Autor:
Masato Yamada, Kazunori Sakamoto, Satoshi Ueda, Nobutaka Oohata, Seiji Hashimoto, Motohiro Hino, Michio Yamashita, Masaru Tsuboi
Publikováno v:
The Journal of antibiotics. 63(2)
A simple and rapid screen was performed for microorganisms producing cyclic lipopeptide acylase, an enzyme that deacylates the acyl side chain of FR901379 to yield a cyclic peptide, FR179642, which is an important intermediate in producing micafungin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98ae61d224b50c8b84cd4870c90a923
https://pubmed.ncbi.nlm.nih.gov/20010796
https://pubmed.ncbi.nlm.nih.gov/20010796
Autor:
Toshitaka Manda, Kyoichi Shimomura, Yoshinori Naoe, E. Lacey, Nobutaka Oohata, Ikuo Kawamura, Sanae Matsumoto, Susumu Tsujimoto, Fusako Nishigaki
Publikováno v:
The Journal of antibiotics. 48(8)
The pharmacological and antitumor effects of FR901537, a new aromatase inhibitor, isolated from Bacillus sp. No. 3072, were studied. Treatment for four consecutive days with FR901537 inhibited the androstenedione-induced increase in the uterus weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c431082c2bcb3c37a7f044d2fb01bbb5
https://pubmed.ncbi.nlm.nih.gov/7592018
https://pubmed.ncbi.nlm.nih.gov/7592018
Autor:
Hiroshi Terano, Shigehiro Takase, Nobutaka Oohata, Yukiko Yamagishi, Michio Yamashita, Yasuhiro Hori, Takashi Fujita, Masakuni Okuhara
Publikováno v:
The Journal of antibiotics. 48(8)
FR901537 is a new aromatase inhibitor produced by a bacterium Bacillus sp. No. 3072. Structural studies of FR901537 suggested that it was a novel naphthol derivative having pantetheine in its structure. FR901537 showed a potent inhibitory activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5e870fa58c2b295315a04a2bd1abf1
https://pubmed.ncbi.nlm.nih.gov/7592017
https://pubmed.ncbi.nlm.nih.gov/7592017