Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Nobuo WATANABE"'
Autor:
Daichi Oshima, Megumi Yoshida, Kosuke Saga, Neo Ito, Miyu Tsuji, Atsuko Isu, Nobuo Watanabe, Ken-ichi Wakabayashi, Kenjiro Yoshimura
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107926- (2023)
Summary: Cilia are organelles involved in motility and sensory transduction, but how these two functions coexist has not been elucidated in depth. Here, the involvement of the ciliary transient receptor potential (TRP) channel TRP11 in mechanorespons
Externí odkaz:
https://doaj.org/article/982bf09977f3429b8f6c3bb5b163e0e6
Autor:
Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma. Normally, podocytes
Externí odkaz:
https://doaj.org/article/63a44e4c87434313920b8891f396fd2a
Autor:
Antony P. McNamee, Michael J. Simmonds, Masataka Inoue, Jarod T. Horobin, Masaya Hakozaki, John F. Fraser, Nobuo Watanabe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The viscoelastic properties of red blood cells (RBC) facilitate flexible shape change in response to extrinsic forces. Their viscoelasticity is intrinsically linked to physical properties of the cytosol, cytoskeleton, and membrane—all of w
Externí odkaz:
https://doaj.org/article/074899ad5cf14667afd29a18cfa3dcd4
Publikováno v:
AIP Advances, Vol 12, Iss 9, Pp 095020-095020-9 (2022)
We report the development of a precision sinusoidal shear flow generator that creates an oscillatory shear flow in the narrow gap between two parallel glass plates moving in opposite directions, thereby allowing direct observation of the cyclical def
Externí odkaz:
https://doaj.org/article/8086dccb02e24f8e9b6d38064612164b
Autor:
Nobuo Watanabe, Masako Kidokoro, Makiko Tanaka, Shigeaki Inoue, Tomoatsu Tsuji, Hisako Akatuska, Chisa Okada, Yumi Iida, Yoshinori Okada, Yusuke Suzuki, Takehito Sato, Takashi Yahata, Noriaki Hirayama, Yoshihide Nakagawa, Sadaki Inokuchi
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-22 (2020)
Abstract Background The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are therefore, suggested to
Externí odkaz:
https://doaj.org/article/5a1af4a7f9584ec687fe39ffbfbe6e70
Autor:
Makoto Higuchi, Nobuo Watanabe
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270977 (2022)
Although both the erythrocyte sedimentation rate (ESR) and optically measured erythrocyte aggregation parameters are affected by the hematocrit, this interaction is not considered by the method used to estimate ESR that considers aggregation paramete
Externí odkaz:
https://doaj.org/article/2797d626863f4dbbbe12b46364aa5d09
Autor:
Nobuo Watanabe, Yusuke Suzuki, Takahisa Yonezu, Yuki Nakagawa, Takashi Shiina, Noriaki Hirayama, Sadaki Inokuchi, Shigeaki Inoue
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A number of autoimmune diseases are associated with the genotypes of human leukocyte antigen class II (HLA), some of which present peptides derived from self-proteins, resulting in clonal expansion of self-reactive T cells. Therefore, select
Externí odkaz:
https://doaj.org/article/a45b10110a54476c84daacb6b46f2609
Autor:
Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222331 (2019)
Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, whic
Externí odkaz:
https://doaj.org/article/c54fab57e9d14e70b7d85211ec6bb248
Autor:
Nobuo Watanabe, Kirill Kryukov, So Nakagawa, Junko S Takeuchi, Meiko Takeshita, Yukiko Kirimura, Satomi Mitsuhashi, Toru Ishihara, Hiromichi Aoki, Sadaki Inokuchi, Tadashi Imanishi, Shigeaki Inoue
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202049 (2018)
Prompt identification of causative pathogenic bacteria is imperative for the treatment of patients suffering from infectious diseases, including sepsis and pneumonia. However, current culture-based methodologies have several drawbacks including their
Externí odkaz:
https://doaj.org/article/6bde8aa77f3d48fca9574b1493f80650
Autor:
Kodai Suzuki, Shigeaki Inoue, Seiji Morita, Nobuo Watanabe, Ayumi Shintani, Sadaki Inokuchi, Shinji Ogura
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145963 (2016)
Although emergency resuscitative thoracotomy is performed as a salvage maneuver for critical blunt trauma patients, evidence supporting superior effectiveness of emergency resuscitative thoracotomy compared to conventional closed-chest compressions r
Externí odkaz:
https://doaj.org/article/090e59c6073e4e40809762542617de64