Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Nobuo N. Noda"'
Autor:
Nobuo N. Noda
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
ABSTRACTAtg8 and Atg12 are ubiquitin-like proteins, conjugated to phosphatidylethanolamine (PE) and Atg5, respectively, through enzymatic reactions similar to ubiquitylation. The resultant Atg8–PE and Atg12–Atg5 conjugates play crucial roles in a
Externí odkaz:
https://doaj.org/article/b8109ddd636343e89118105dc3f55084
Autor:
Daisuke Noshiro, Nobuo N. Noda
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102633- (2023)
Summary: High-speed atomic force microscopy is a technique that allows real-time observation of biomolecules and biological phenomena reconstituted on a substrate. Here, we present a protocol for immobilizing lipid nanorods onto two-dimensional cryst
Externí odkaz:
https://doaj.org/article/6ca5f1e6839b4f3f903cc2fc0fbdf003
Autor:
Tatsuro Maruyama, Nobuo N. Noda.
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102590- (2023)
Summary: Yeast mitofissin Atg44 is a mitochondrial intermembrane space protein that causes membrane fission required for mitophagy. Here, we present a protocol for observing Atg44-mediated membrane fission. We describe steps for recombinant Atg44 pur
Externí odkaz:
https://doaj.org/article/88da1963d1d04a929b282976976cb55b
Autor:
Vladimir V. Rogov, Ioannis P. Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N. Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G. McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A. Tooze, Ivan Dikic, Trond Lamark, Terje Johansen
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the
Externí odkaz:
https://doaj.org/article/efb1c686968d4bd0982e2069b219cc78
Autor:
Ryosuke Ishimura, Afnan H. El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol Lee-Okada, Tarek M. Mohamed, Takehiko Yokomizo, Takashi Ueno, Kenji Sakimura, Tohru Natsume, Hiroyuki Sorimachi, Toshifumi Inada, Satoshi Waguri, Nobuo N. Noda, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The UFM1 system, a ubiquitin-like conjugation system is crucial for endoplasmic reticulum (ER) homeostasis. Here, authors found that CYB5R3 is covalently conjugated with UFM1, which becomes a signal for ER-phagy, a selective autophagy of ER.
Externí odkaz:
https://doaj.org/article/fedd7858566a4c3695542e6f98801031
Autor:
Yuji Kubota, Yuko Fujioka, Ashwini Patil, Yusuke Takagi, Daisuke Matsubara, Masatomi Iijima, Isao Momose, Ryosuke Naka, Kenta Nakai, Nobuo N. Noda, Mutsuhiro Takekawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MEK1 mutations are found in cancer and RASopathies, but their effects remain unclear. Here, the authors reveal a mutant MEK1 structure and qualitative differences in biological properties between the cancer- and RASopathy-associated mutants, providin
Externí odkaz:
https://doaj.org/article/9947a9cf2139440e875defedf512d313
Autor:
Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N. Noda, Kouhei Tsumoto, Tatsuya Maeda
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Tanigawa et al. investigate the role of Pib2, a vacuolar protein, in the glutamine-dependent upstream regulation of TORC1 in budding yeast. Their study reveals that Pib2 plays dual roles as a glutamine sensor and a direct TORC1 activator, a finding u
Externí odkaz:
https://doaj.org/article/275a9dd4eb7942b5a85bf66596d18969
Autor:
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Liquid-liquid phase separation of p62/SQSTM1 has been previously described, although the significance in vivo remains unclear. Here the authors show p62 droplets contain ubiquitin, autophagy-related proteins and Keap1 to serve as platform of not only
Externí odkaz:
https://doaj.org/article/50de4fe4211844b99cf42f1bafec73c8
Autor:
Keisuke Mochida, Akinori Yamasaki, Kazuaki Matoba, Hiromi Kirisako, Nobuo N. Noda, Hitoshi Nakatogawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The ER is subject to autophagy (ER-phagy) for turnover, with Atg40 acting as a receptor to sequester ER with Atg8 in autophagosomes. Here, the authors show that Atg40 is clustered by interaction with Atg8 to generate local membrane curvature and prom
Externí odkaz:
https://doaj.org/article/b661a782e7a349a3ac3c2d7882684247
Autor:
Akinori Yamasaki, Yasunori Watanabe, Wakana Adachi, Kuninori Suzuki, Kazuaki Matoba, Hiromi Kirisako, Hiroyuki Kumeta, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki, Nobuo N. Noda
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 19-27 (2016)
Selective autophagy mediates the degradation of various cargoes, including protein aggregates and organelles, thereby contributing to cellular homeostasis. Cargo receptors ensure selectivity by tethering specific cargo to lipidated Atg8 at the isolat
Externí odkaz:
https://doaj.org/article/2145ef6370a34e13b22cd5456ff4702c