Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Nobuo Horikoshi"'
Autor:
Sharmistha Chakraborty, Mayank Singh, Raj K. Pandita, Vipin Singh, Calvin S.C. Lo, Fransisca Leonard, Nobuo Horikoshi, Eduardo G. Moros, Deblina Guha, Clayton R. Hunt, Eric Chau, Kazi M. Ahmed, Prayas Sethi, Vijaya Charaka, Biana Godin, Kalpana Makhijani, Harry Scherthan, Jeanette Deck, Michael Hausmann, Arjamand Mushtaq, Mohammad Altaf, Kenneth S. Ramos, Krishna M. Bhat, Nitika Taneja, Chandrima Das, Tej K. Pandita
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104142- (2022)
Summary: Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear. Here we report that hyperthermia dec
Externí odkaz:
https://doaj.org/article/c0996799142844549be35341cfc4a7d5
Autor:
Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as
Externí odkaz:
https://doaj.org/article/024c2a17f581441ca1d27fe75c08a597
Autor:
Meredith M. Ogle, Rolando Trevino, Joseph Schell, Mahboubeh Varmazyad, Nobuo Horikoshi, David Gius
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 635 (2022)
The loss and/or dysregulation of several cellular and mitochondrial antioxidants’ expression or enzymatic activity, which leads to the aberrant physiological function of these proteins, has been shown to result in oxidative damage to cellular macro
Externí odkaz:
https://doaj.org/article/6836ea2529e64b87bbdc915a19a4d5e8
Autor:
Kalpana Mujoo, Raj K. Pandita, Anjana Tiwari, Vijay Charaka, Sharmistha Chakraborty, Dharmendra Kumar Singh, Shashank Hambarde, Walter N. Hittelman, Nobuo Horikoshi, Clayton R. Hunt, Kum Kum Khanna, Alexander Y. Kots, E. Brian Butler, Ferid Murad, Tej K. Pandita
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1660-1674 (2017)
Summary: The nitric oxide (NO)-cyclic GMP pathway contributes to human stem cell differentiation, but NO free radical production can also damage DNA, necessitating a robust DNA damage response (DDR) to ensure cell survival. How the DDR is affected by
Externí odkaz:
https://doaj.org/article/13641d91a394421badaa373d18aad31e
Autor:
Anirban Chakraborty, Nisha Tapryal, Tatiana Venkova, Nobuo Horikoshi, Raj K. Pandita, Altaf H. Sarker, Partha S. Sarkar, Tej K. Pandita, Tapas K. Hazra
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.
Externí odkaz:
https://doaj.org/article/c0190224ff2c4b5b97ae064cba887a7a
Autor:
Arun Gupta, Clayton R. Hunt, Muralidhar L. Hegde, Sharmistha Chakraborty, Durga Udayakumar, Nobuo Horikoshi, Mayank Singh, Deepti B. Ramnarain, Walter N. Hittelman, Sarita Namjoshi, Aroumougame Asaithamby, Tapas K. Hazra, Thomas Ludwig, Raj K. Pandita, Jessica K. Tyler, Tej K. Pandita
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 177-189 (2014)
Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-tr
Externí odkaz:
https://doaj.org/article/c8376fdb5bc64a05a849a90707c6fa80
Autor:
Masahiro Inoue, Kouichi Yasuda, Haruki Uemura, Natsumi Yasaka, Hiroshi Inoue, Yoshitatsu Sei, Nobuo Horikoshi, Toshihide Fukuma
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15566 (2010)
BACKGROUND: The 14-3-3 proteins are structurally conserved throughout eukaryotes and participate in protein kinase signaling. All 14-3-3 proteins are known to bind to evolutionally conserved phosphoserine-containing motifs (modes 1 and/or 2) with hig
Externí odkaz:
https://doaj.org/article/f5dee102d4684b4cb7a72fc58466fe4c
Related Article from Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a9389b904ccfd53d99fc6f8ceb97eb
https://doi.org/10.1158/1078-0432.22443486.v1
https://doi.org/10.1158/1078-0432.22443486.v1
The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf379b8cffd2c51ad23dd50d1694b3c5
https://doi.org/10.1158/1078-0432.c.6519834.v1
https://doi.org/10.1158/1078-0432.c.6519834.v1
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Supplementary Figure Legend, Methods and Materials, Tables 1-2. Supplementary Table 1. Phase distribution in cells after enrichment by synchronization. Supplementary Table 2. Effect of Ssb1 depletion on spontaneous chromosome aberration frequency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9376887e2277d860429acc3b9d1d1a85
https://doi.org/10.1158/0008-5472.22408032.v1
https://doi.org/10.1158/0008-5472.22408032.v1