Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Nobunao Wakabayashi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4712 (2024)
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given t
Externí odkaz:
https://doaj.org/article/de08ed721c124a22b683adfd46219a2c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13345 (2023)
Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. It leads to a gain of fat deposition in ectopic tissues such as liver and skeletal muscle that results in steatosis, dyslipide
Externí odkaz:
https://doaj.org/article/80b39a3d48854d0a9e6d11ab451fc81f
Autor:
Dionysios V. Chartoumpekis, Dushani L. Palliyaguru, Nobunao Wakabayashi, Nicholas K.H. Khoo, Gabriele Schoiswohl, Robert M. O'Doherty, Thomas W. Kensler
Publikováno v:
Molecular Metabolism, Vol 4, Iss 7, Pp 543-550 (2015)
Objective: The Notch family of intermembrane receptors is highly conserved across species and is involved in cell fate and lineage control. Previous in vitro studies have shown that Notch may inhibit adipogenesis. Here we describe the role of Notch i
Externí odkaz:
https://doaj.org/article/332ad14a0f214a9ca37592e4f708eddb
Publikováno v:
Molecular and Cellular Biology. 43:43-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b24b5e55ec0d42e2f6251747889f140f
https://doi.org/10.1080/10985549.2022.2160610
https://doi.org/10.1080/10985549.2022.2160610
Publikováno v:
Antioxidants & Redox Signaling.
The transcription factor Nrf2 (NF-E2-related factor 2) plays an important role as a master regulator of the cellular defense system by activating transcriptional programs of Nrf2 target genes encoding multiple enzymes related to cellular redox balanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fce3208b4e26d95813eb9663b355288
https://doi.org/10.1089/ars.2022.0200
https://doi.org/10.1089/ars.2022.0200
Autor:
Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto, Thomas W Kensler
Publikováno v:
Molecular Pharmacology. :MOLPHARM-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3122211425e80b2ce5ff6bcaf1a412c9
https://doi.org/10.1124/molpharm.123.000671
https://doi.org/10.1124/molpharm.123.000671
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Notch signaling coordinates cell differentiation processes in the intestinal epithelium. The transcription factor Nrf2 orchestrates defense mechanisms by regulating cellular redox homeostasis, which, as shown previously in murine li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5ec7721d1b9705691950303dd36e56
https://doi.org/10.1016/j.jcmgh.2020.08.013
https://doi.org/10.1016/j.jcmgh.2020.08.013
Autor:
Yoon J. Lee, Jinhwan Lim, Bo Youn Choi, Jae Hoon Sul, Jin Su Park, Jihoon Han, Gahee Bahn, Jeung Whan Han, Mark P. Mattson, Ui Jeong Yun, Thiruma V. Arumugam, Sang-Ha Baik, Jong-Sung Park, Yoon Suk Cho, Soo Han Bae, Hark Kyun Kim, Seung Hyun Baek, Dong-Gyu Jo, Yuri Choi, Nobunao Wakabayashi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:12516-12523
Significance Considering that Alzheimer’s disease (AD) is a chronic disease progressing over a long period of time, even a slight increase of BACE1 expression may have a profound effect on Aβ accumulation. We describe a previously unknown mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25248fd7dcb62ee97a9638f3aa9a83e
https://doi.org/10.1073/pnas.1819541116
https://doi.org/10.1073/pnas.1819541116
Autor:
Yoko Yagishita, Thomas W. Kensler, Nobunao Wakabayashi, Dionysios V. Chartoumpekis, Dushani L. Palliyaguru, John J. Skoko, Shivendra V. Singh
Publikováno v:
Free Radical Biology and Medicine. 101:116-128
Small molecules of plant origin offer presumptively safe opportunities to prevent carcinogenesis, mutagenesis and other forms of toxicity in humans. However, the mechanisms of action of such plant-based agents remain largely unknown. In recent years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276791c16a1ae2c58841ac18927369e7
https://doi.org/10.1016/j.freeradbiomed.2016.10.003
https://doi.org/10.1016/j.freeradbiomed.2016.10.003
Autor:
Patricia K. Coyle, Suzanne Tawch, Suyasha Roy, Nancy McLinskey, Tim D. Oury, Patricia Melville, Patricia Castillo, Waleed Elsegeiny, Hoi Tong Wong, Derek Pociask, Xun Lin, Misty Good, Stephen J. Gaudino, Jay K. Kolls, Kong Chen, Olga Syritsyna, Amit Awasthi, Pawan Kumar, Nobunao Wakabayashi
Publikováno v:
J Immunol
IL-17A and IL-22 derived from Th17 cells play a significant role in mucosal immunity and inflammation. TGF-β and IL-6 promote Th17 differentiation; however, these cytokines have multiple targets. The identification and screening of additional molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81cd3cdd35c570ac0d15ab811cc7f60
https://pubmed.ncbi.nlm.nih.gov/33648937
https://pubmed.ncbi.nlm.nih.gov/33648937