Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Nobumitsu Kobayashi"'
1
Akademický článek
The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the VEGFA gene in Sherpa highlanders
Autor: Yunden Droma, Masayuki Hanaoka, Takumi Kinjo, Nobumitsu Kobayashi, Masanori Yasuo, Yoshiaki Kitaguchi, Masao Ota
Publikováno v: PeerJ, Vol 10, p e13893 (2022)
Background Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, which may be achieved by mechanisms promoting microcirculatory blood flow and capillary density at high altitudes for restoring oxygen supply to tissues.
Externí odkaz: https://doaj.org/article/fbb03e5b42704302a5cf28fecc08b5f6
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2
Akademický článek
Diffuse Endobronchial Wall Spread of Metastatic Breast Cancer
Autor: Tomonobu Koizumi, Nobumitsu Kobayashi, Shintarou Kanda, Masanori Yasuo, Keishi Kubo, Kenichi Itou
Publikováno v: Case Reports in Oncology, Vol 2, Iss 2, Pp 77-83 (2009)
We present here a case of diffuse tracheobronchial wall spread of metastatic breast cancer who was successfully treated with trastuzumab plus vinorelbine chemotherapy. The patient had a left radical mastectomy for breast cancer in March 2000 and deve
Externí odkaz: https://doaj.org/article/cf5be395b71e4903bc7a69805c183ff3
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3
Akademický článek
Polymorphisms of the tissue inhibitor of metalloproteinase 3 gene are associated with resistance to high-altitude pulmonary edema (HAPE) in a Japanese population: a case control study using polymorphic microsatellite markers.
Autor: Nobumitsu Kobayashi, Masayuki Hanaoka, Yunden Droma, Michiko Ito, Yoshihiko Katsuyama, Keishi Kubo, Masao Ota
Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71993 (2013)
INTRODUCTION: High-altitude pulmonary edema (HAPE) is a hypoxia-induced, life-threatening, high permeability type of edema attributable to pulmonary capillary stress failure. Genome-wide association analysis is necessary to better understand how gene
Externí odkaz: https://doaj.org/article/7df0ee89fdff4b82981d939a47bf0c83
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4
Akademický článek
Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas.
Autor: Masayuki Hanaoka, Yunden Droma, Buddha Basnyat, Michiko Ito, Nobumitsu Kobayashi, Yoshihiko Katsuyama, Keishi Kubo, Masao Ota
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50566 (2012)
Sherpas comprise a population of Tibetan ancestry in the Himalayan region that is renowned for its mountaineering prowess. The very small amount of available genetic information for Sherpas is insufficient to explain their physiological ability to ad
Externí odkaz: https://doaj.org/article/2eb4df8f2192437993204aa9cec0a263
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6
The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the
Autor: Yunden, Droma, Masayuki, Hanaoka, Takumi, Kinjo, Nobumitsu, Kobayashi, Masanori, Yasuo, Yoshiaki, Kitaguchi, Masao, Ota
Publikováno v: PeerJ. 10
Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, which may be achieved by mechanisms promoting microcirculatory blood flow and capillary density at high altitudes for restoring oxygen supply to tissues. Vascular en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20d82dff528000ecc1aa88c83fef2618
https://pubmed.ncbi.nlm.nih.gov/35996666
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7
Human exome analysis of candidate genetic variants for susceptibility to high-altitude pulmonary edema in Japanese
Autor: Yunden Droma, Nobumitsu Kobayashi, Masao Ota, Masayuki Hanaoka
Publikováno v: Genes and environment.
High-altitude pulmonary edema (HAPE) is a non-cardiogenic pulmonary edema that develops in unacclimatized healthy individuals at altitudes above 2,500 m. Previous studies suggest genetic component in its etiology of HAPE, however, the genetic basis r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae8ee97887c9c19e086106c8d52c5fc8
https://doi.org/10.1183/13993003.congress-2020.1126
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8
Hypoxia-tolerant vascular endothelial growth factor-A (VEGF-A) and the genetic variations of VEGFA in Sherpa highlanders
Autor: Masayuki Hanaoka, Nobumitsu Kobayashi, Shuhei Nozawa, Yunden Droma, Masao Ota, Masanori Yasuo, Buddha Basnyat, Yoshiaki Kitaguchi, Takumi Kinjo
Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, partly by one of the adaptation mechanisms promoting increases of microcirculatory blood flow and capillary density at high altitude for restoring oxygen supply to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468e0ecfac33dd75fd11a34850123d3a
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10
Electron Microscopy Observation of Human Pulmonary Ultrastructure in Two Patients with High-Altitude Pulmonary Edema
Autor: Takashi Ichiyama, Nobumitsu Kobayashi, Yunden Droma, Takayuki Honda, Akane Kato, Masayuki Hanaoka, Takeshi Uehara
Publikováno v: High Altitude Medicine & Biology. 18:288-291
We examined the pulmonary ultrastructure in tissue from two patients with high-altitude pulmonary edema (HAPE) by electron microscopy. In one case, we found that neutrophils were trapped in pulmonary capillary lumen of alveolar-capillary wall and par
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b041911c88333a0b38d61fcfcd5a3
https://doi.org/10.1089/ham.2016.0163
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