Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Nobumitsu, Hanioka"'
Autor:
Nobumitsu, Hanioka, Toshiko, Tanaka-Kagawa, Yoko, Mori, Shinichi, Ikushiro, Hideto, Jinno, Susumu, Ohkawara, Takashi, Isobe
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1116-1123
Flavones, which are distributed in a variety of plants and foods in nature, possess significant biological activities, including antitumor and anti-inflammatory effects, and are metabolized into glucuronides by uridine 5'-diphosphate (UDP)-glucuronos
Autor:
Yoko Mori, Akira Aoki, Yoshinori Okamoto, Takashi Isobe, Susumu Ohkawara, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Hideto Jinno
Publikováno v:
Biologicalpharmaceutical bulletin. 45(12)
Phthalic acid (PA) diesters are widely used in consumer products, as plasticizers, and are ubiquitous environmental pollutants. There is a growing concern about their adjuvant effect on allergic diseases. Although its precise mechanism remains unknow
Autor:
Yoko Mori, Akira Aoki, Yoshinori Okamoto, Takashi Isobe, Susumu Ohkawara, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Hideto Jinno
Publikováno v:
Biologicalpharmaceutical bulletin. 45(8)
Bitter taste receptors (TAS2Rs) are expressed by oral cavity cells in mammals and classically function as sensors for bitter compounds. There are 25 functional isoforms of human TAS2Rs, with individual bitter ligands. Each human TAS2R isoform is dist
Autor:
Toshiko Tanaka-Kagawa, Hideto Jinno, Keita Saito, Takashi Isobe, Susumu Ohkawara, Nobumitsu Hanioka
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:218-225
Favipiravir is an antiviral agent effective against several RNA viruses that is converted into an inactive oxidative metabolite (M1), mainly by aldehyde oxidase, in humans. In the present study, the biotransformation of favipiravir into M1 in male an
Autor:
Takashi Isobe, Susumu Ohkawara, Yoko Mori, Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka
Publikováno v:
Chemico-Biological Interactions. 372:110353
Publikováno v:
Drug and Chemical Toxicology. 45:1565-1569
Bisphenol A (BPA) is an endocrine-disrupting chemical, and is predominantly metabolized into glucuronide in mammals. The present study was conducted in order to examine the hepatic and intestinal g...
Autor:
Takashi Kitaguchi, Shimeng Qiu, Taisei Mizota, Nobumitsu Hanioka, Kazuhiro Kobayashi, Ito Mina, Katsutoshi Ohno, Mitsuru Tanaka, Takahiro Iwao, Tamihide Matsunaga, Isamu Ogawa
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(1)
Pharmacokinetic prediction after oral ingestion is important for quantitative risk assessment of food-derived compounds. To evaluate the utility of human intestinal absorption prediction, we compared the membrane permeability and metabolic activities
Autor:
Nobumitsu Hanioka, Takashi Isobe, Hideto Jinno, Toshiko Tanaka-Kagawa, Sadayuki Ochi, Susumu Ohkawara
Publikováno v:
Toxicology in Vitro. 54:237-242
Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that is rapidly metabolized to mono(2-ethylhexyl) phthalate (MEHP), an active metabolite, in mammals. In the present study, the hydrolysis of DEHP by the liver and intestinal microsomes o
Autor:
Tsuyoshi Kawakami, Yoshiaki Ikarashi, Masahiro Chiba, Maiko Tahara, Hideto Jinno, Ikuo Kawamura, Nobuhiko Miura, Aya Onuki, Nobumitsu Hanioka, Toshiko Tanaka-Kagawa, Shiori Oizumi, Shinobu Sakai, Ikue Saito, Hitoshi Uemura
Publikováno v:
BPB Reports. 2:86-90
Autor:
Nobumitsu Hanioka, Maho Taguchi, Hiromitsu Yamamoto, Hitomi Teramachi, Masato Shigeyama, Mikio Murata, Noriko Ogawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:1824-1829
Mohs paste (MP) is a hospital preparation containing zinc hydrochloride and zinc oxide starch. It is a topical medication used to fixate tissues for the removal of inoperable skin tumors and the management of hemorrhage and exudates, and to prevent f