Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Nobumasa Watanabe"'
Autor:
Daisuke Mori, Nobumasa Watanabe, Osamu Kaminuma, Takahisa Murata, Takachika Hiroi, Hiroshi Ozaki, Masatoshi Hori
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 4, Pp 394-405 (2014)
Abstract.: Intestinal inflammation causes disorder in bowel motility. Th17 cytokines are involved in intestinal inflammation. To understand the role of interleukin (IL)-17 in intestinal motility, we examined effects of IL-17A on contractile activitie
Externí odkaz:
https://doaj.org/article/c324395b558545b38ce7d00c7102f17d
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150244 (2016)
Th17 cells and Foxp3+ regulatory T cells (Tregs) are thought to promote and suppress inflammatory responses, respectively. However, whether they counteract each other or synergize in regulating immune reactions remains controversial. To determine the
Externí odkaz:
https://doaj.org/article/0d80d0f4164b4aeda551d116a9c60691
Autor:
Kenji Kawabata, Nobumasa Watanabe, Yuzo Koda, Fuminori Sakurai, Osamu Kaminuma, Takachika Hiroi, Kazufumi Katayama, Masashi Tachibana, Yukako Oya, Hiroyuki Mizuguchi, Zifei Fan
Publikováno v:
International Immunology
IL-10 is an immune regulatory cytokine and its genetic defect leads to gastrointestinal inflammation in humans and mice. Moreover, the IL-23/Th17 axis is known to be involved in these inflammatory disorders. IL-17A, a representative cytokine produced
Autor:
Yuhya Wakasa, Hidenori Takagi, Nobumasa Watanabe, Noriko Kitamura, Yoshihiro Fujiwara, Yuko Ogo, Shimpei Hayashi, Lijun Yang, Masaru Ohta, Wai Wai Thet Tin, Kenji Sekikawa, Makoto Takano, Kenjirou Ozawa, Takachika Hiroi, Fumio Takaiwa
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120209 (2015)
The endoplasmic reticulum-derived type-I protein body (PB-I) from rice endosperm cells is an ideal candidate formulation for the oral delivery of bioencapsulated peptides as tolerogens for allergen-specific immunotherapy. In the present study, PBs co
Externí odkaz:
https://doaj.org/article/09f7997627884e23bc5e7ea946577b60
Autor:
Tomoe Nishimura, Takachika Hiroi, Mayumi Saeki, Kimihiro Okubo, Akihiro Nakaya, Osamu Kaminuma, Minoru Gotoh, Noriko Kitamura, Nobumasa Watanabe, Kazufumi Katayama
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO1-4
Autor:
Akio Mori, Osamu Kaminuma, Noriko Kitamura, Mayumi Saeki, Shigeki Katoh, Nobumasa Watanabe, Takachika Hiroi, Taeko Miyagi, Tomoe Nishimura
Publikováno v:
Genes to Cells. 23:112-116
Neuraminidase family enzymes that hydrolyze the terminal sialic acid linkage in biomolecules are involved in various immune responses. We previously showed that Th1 and Th2 cells differentially express several neuraminidases. Herein, the expression o
Autor:
Tomoe Nishimura, Hideki Tatsumi, Mayumi Shindo, Nobumasa Watanabe, Soichi Nemoto, Takachika Hiroi, Kimihiro Okubo, Akio Mori, Osamu Kaminuma, Noriko Kitamura, Mayumi Saeki, Minoru Gotoh
Publikováno v:
Allergology international : official journal of the Japanese Society of Allergology.
Autor:
Nobumasa Watanabe, Pin-Yu Perera, Takachika Hiroi, Thomas A. Waldmann, Seiji Yokoyama, Liyanage P. Perera, Seigo Terawaki, Osamu Kaminuma
Publikováno v:
J Clin Immunol
PURPOSE: Autoimmune lymphoproliferative syndrome (ALPS) is a non-malignant genetic disorder of lymphocyte homeostasis with defective Fas-mediated apoptosis. Current therapies for ALPS primarily target autoimmune manifestations with non-specific immun
Publikováno v:
Plant Biotechnology. 32:329-332
Autor:
Noriko Kitamura, Osamu Kaminuma, Akio Mori, Tomoe Nishimura, Mayumi Saeki, Takachika Hiroi, Nobumasa Watanabe
Publikováno v:
Biologicalpharmaceutical bulletin. 40(10)
CD4+ T cells play a critical role in the development of allergic inflammation in several target organs. Various adhesion molecules are involved in the local recruitment of T cells and other inflammatory cells. We investigated the differential contrib