Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Nobuko Uchida"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102674- (2023)
Summary: Prospective isolation of defined cell types is critical for the functional study of stem cells, especially in primary human tissues. Here, we present a protocol for purifying 10 transcriptomically and functionally distinct neural stem and pr
Externí odkaz:
https://doaj.org/article/fcc200bd5513479c9874a52abfb3d13d
Autor:
Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.
Externí odkaz:
https://doaj.org/article/1bf355be0de745bc987455ce3536745a
Autor:
Daniel P. Dever, Samantha G. Scharenberg, Joab Camarena, Eric J. Kildebeck, Joseph T. Clark, Renata M. Martin, Rasmus O. Bak, Yuming Tang, Monika Dohse, Johannes A. Birgmeier, Karthik A. Jagadeesh, Gill Bejerano, Ann Tsukamoto, Natalia Gomez-Ospina, Nobuko Uchida, Matthew H. Porteus
Publikováno v:
iScience, Vol 15, Iss , Pp 524-535 (2019)
Summary: Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural injuries. Gene editing in NSCs (GE-NSCs) could enhance their therapeutic potential. W
Externí odkaz:
https://doaj.org/article/2fa9e32ecf84457fb9e04fdb55b3dba9
Autor:
Katja M. Piltti, Gabriella M. Funes, Sabrina N. Avakian, Ara A. Salibian, Kevin I. Huang, Krystal Carta, Noriko Kamei, Lisa A. Flanagan, Edwin S. Monuki, Nobuko Uchida, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1534-1548 (2017)
Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cel
Externí odkaz:
https://doaj.org/article/9fa2f646accf495fbb127312df542fdb
Autor:
Katja M. Piltti, Sabrina N. Avakian, Gabriella M. Funes, Antoinette Hu, Nobuko Uchida, Aileen J. Anderson, Brian J. Cummings
Publikováno v:
Stem Cell Research, Vol 15, Iss 2, Pp 341-353 (2015)
The effect of transplantation dose on the spatiotemporal dynamics of human neural stem cell (hNSC) engraftment has not been quantitatively evaluated in the central nervous system. We investigated changes over time in engraftment/survival, proliferati
Externí odkaz:
https://doaj.org/article/1136d545b49c40e9a699d4692a6dc2e2
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 620-632 (2014)
The microenvironment is a critical mediator of stem cell survival, proliferation, migration, and differentiation. The majority of preclinical studies involving transplantation of neural stem cells (NSCs) into the CNS have focused on injured or degene
Externí odkaz:
https://doaj.org/article/4130ad301f6c47aaa93ef09514384e25
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12272 (2010)
Traumatic spinal cord injury (SCI) results in partial or complete paralysis and is characterized by a loss of neurons and oligodendrocytes, axonal injury, and demyelination/dysmyelination of spared axons. Approximately 1,250,000 individuals have chro
Externí odkaz:
https://doaj.org/article/41c85fbd8c944b838a31eb42a1d62911
Autor:
Mitra J Hooshmand, Christopher J Sontag, Nobuko Uchida, Stan Tamaki, Aileen J Anderson, Brian J Cummings
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5871 (2009)
BACKGROUND:Human central nervous system-stem cells grown as neurospheres (hCNS-SCns) self-renew, are multipotent, and have potential therapeutic applications following trauma to the spinal cord. We have previously shown locomotor recovery in immunode
Externí odkaz:
https://doaj.org/article/b857db4b980c4c59a949e791ebe2ebf1
Autor:
Sanjiv Sam Gambhir, Lawrence D. Recht, Seema Nagpal, Reena Thomas, Guido Davidzon, Andrei Iagaru, Tarik F. Massoud, Mehdi Khalighi, Melanie Hayden-Gephart, Irving Weissman, Geoffrey I. Warnock, Donald E. Born, Pauline Chu, Rahul Sinha, Nobuko Uchida, Daniel Dan Liu, Eli Johnson, Monica Granucci, Joy Q. He, Harsh Gandhi, Kim Halbert, Dawn Holley, Michelle L. James, Israt S. Alam, Mary Ellen I. Koran, Jun Hyung Park, Bin Shen, Pablo Buccino, Megan Phillips, Samantha T. Reyes, Jessa B. Castillo, Lewis Naya, Surya Murty, Tom Haywood, Chirag B. Patel, Corinne Beinat
Clinical Characteristics of patients imaged with [18F]DASA-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec9dde6a1f7fe80c88f4fd33b870b3a
https://doi.org/10.1158/1078-0432.22483781
https://doi.org/10.1158/1078-0432.22483781
Autor:
Sanjiv Sam Gambhir, Lawrence D. Recht, Seema Nagpal, Reena Thomas, Guido Davidzon, Andrei Iagaru, Tarik F. Massoud, Mehdi Khalighi, Melanie Hayden-Gephart, Irving Weissman, Geoffrey I. Warnock, Donald E. Born, Pauline Chu, Rahul Sinha, Nobuko Uchida, Daniel Dan Liu, Eli Johnson, Monica Granucci, Joy Q. He, Harsh Gandhi, Kim Halbert, Dawn Holley, Michelle L. James, Israt S. Alam, Mary Ellen I. Koran, Jun Hyung Park, Bin Shen, Pablo Buccino, Megan Phillips, Samantha T. Reyes, Jessa B. Castillo, Lewis Naya, Surya Murty, Tom Haywood, Chirag B. Patel, Corinne Beinat
Imaging of IC-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab52692cef6a1bbb981347528b209ae
https://doi.org/10.1158/1078-0432.22483796
https://doi.org/10.1158/1078-0432.22483796