Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Nobuko Nishimura"'
Autor:
Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton
Publikováno v:
Journal of medicinal chemistry. 65(6)
Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, h
Autor:
Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee
Publikováno v:
Journal of Medicinal Chemistry. 63:52-65
Autor:
Nobuko Nishimura
Publikováno v:
The Proceedings of the Annual Convention of the Japanese Psychological Association. 83:3A-079
Autor:
Yusuke Maeda, Nobuko Nishimura, Mayumi Endo, Osamu Kinoshita, Reiko Tsunoda, Yasushi Abe, Hiroaki Fushiki
Publikováno v:
Equilibrium Research. 77:30-37
Publikováno v:
Equilibrium Research. 77:17-21
Autor:
Tamayo, Nuria A., Bourbeau, Matthew P., Allen, Jennifer R., Ashton, Kate S., Chen, Jian Jeffrey, Kaller, Matthew R., Nguyen, Thomas T., Nobuko Nishimura, Pettus, Liping H., Walton, Mary, Belmontes, Brian, Moriguchi, Jodi, Kui Chen, McCarter, John D., Hanestad, Kelly, Chung, Grace, Ninniri, Maria Stefania S., Jan Sun, Poppe, Leszek, Spahr, Chris
Publikováno v:
Journal of Medicinal Chemistry; 3/24/2022, Vol. 65 Issue 6, p4972-4990, 19p
Publikováno v:
The Proceedings of the Annual Convention of the Japanese Psychological Association. 81:3A-034
Autor:
Yusuke Maeda, Nobuko Nishimura, Reiko Tsunoda, Hiroaki Fushiki, Osamu Kinoshita, Mayumi Endo, Yasushi Abe
Publikováno v:
Equilibrium Research. 76:692-697
Autor:
Zihao Hua, Michele Potashman, Carol Babij, Manory Fernando, Nobuko Nishimura, Josette Carnahan, Joseph L. Kim, Linda F. Epstein, Matthew R. Lee, Kevin Yang, Richard T. Lewis, Douglas A. Whittington, Longbin Liu, Karina R. Vaida, Howard Bregman, Shuyan Yi, Mark H. Norman, Matthew W. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2215-2234
One of the challenges for targeting B-Raf(V600E) with small molecule inhibitors had been achieving adequate selectivity over the wild-type protein B-Raf(WT), as inhibition of the latter has been associated with hyperplasia in normal tissues. Recent s
Autor:
Michael D. Bartberger, Michael Croghan, Carolyn Moyer, David Lloyd, Rod Cupples, Seifu Tadesse, Nobuko Nishimura, Ke Kong, Gwyneth Van, Christopher H. Fotsch, Randall W. Hungate, David J. St. Jean, Kevin Yang, Kate Ashton, Mark H. Norman, Samer Chmait, Longbin Liu, Lewis D. Pennington, Fang-Tsao Hong, Matthew P. Bourbeau, Clarence Hale, Jiandong Zhang, Aaron C. Siegmund, Jie Chen, Christopher M. Tegley, Steven R. Jordan, Kristin L. Andrews, Klaus Michelsen, Guomin Yao, Glenn Sivits, Andreas Reichelt, Joan Helmering
Publikováno v:
Journal of Medicinal Chemistry. 58:9663-9679
The HTS-based discovery and structure-guided optimization of a novel series of GKRP-selective GK-GKRP disrupters are revealed. Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 μM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0