Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nobuki Sakauchi"'
Autor:
Satoshi Mizuta, Hiroki Otaki, Takeshi Ishikawa, Juliann Nzembi Makau, Tomoko Yamaguchi, Takuya Fujimoto, Nobuyuki Takakura, Nobuki Sakauchi, Shuji Kitamura, Hikaru Nono, Ryota Nishi, Yoshimasa Tanaka, Kohsuke Takeda, Noriyuki Nishida, Ken Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 65:369-385
Influenza viruses are responsible for contagious respiratory illnesses in humans and cause seasonal epidemics and occasional pandemics worldwide. Previously, we identified a quinolinone derivative
Autor:
Kyoko Yoshikawa, Ikumi Chisaki, Toshitake Okui, Kazuyoshi Aso, Haruhiko Kuno, Kousuke Hidaka, Tawaraishi Taisuke, Nobuki Sakauchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3067-3072
CCR6 has been implicated in both autoimmune diseases and non-autoimmune diseases. Thus, inhibition of CCR6-dependent cell migration is an attractive strategy for their treatment. An orally available small molecule inhibitor of CCR6 could therefore be
Autor:
Junya Shirai, Masato Yoshida, Ayumu Sato, Nobuki Sakauchi, Haruhiko Kuno, Reiko Saikawa, Hideki Furukawa
Publikováno v:
European Journal of Medicinal Chemistry. 139:114-127
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α 1D adrenoceptor (α 1D adrenergic receptor; α 1D –AR) antagonists. Compound 7 was taken from our internal compound collection as an at
Autor:
Satoshi Mizuta, Hiroki Otaki, Takeshi Ishikawa, Makau, Nzembi, Juliann, Tomoko Yamaguchi, Takuya Fujimoto, Nobuyuki Takakura, Nobuki Sakauchi, Shuji Kitamura, Hikaru Nono, Ryota Nishi, Yoshimasa Tanaka, Kohsuke Takeda, Noriyuki Nishida, Ken Watanabe
Publikováno v:
Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p369-385, 17p
Autor:
Hironobu Maezaki, Maki Miyamoto, Miki Hara, Norio Tada, Hisashi Fujita, Junya Shirai, Katsuhiko Miwa, Nobuki Sakauchi, Haruhiko Kuno, Nagako Kameoka, Ayumu Sato, Hideki Furukawa
Publikováno v:
Tetrahedron. 72:6334-6339
5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride (TAK-259) is a novel, selective, and orally active α1D adrenoceptor antagonist with anti-urinary frequency effect. A metabolite (2) of TAK-259 was
Autor:
Maiko Takiguchi, Hiroyuki Ueno, Yoshihisa Nakada, Masami Yamada, Tomoya Yukawa, Tetsuya Tsukamoto, Hideyuki Nakagawa, Nobuki Sakauchi, Kamei Taku, Ikuo Fujimori, Tomoko Igari, Masako Kuno, Yasushi Fujioka, Izumi Kamo, Yuji Ishichi, Yusuke Ohba
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3716-3726
Peripheral-selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Here, we describe our medicinal chemistry approach to discover
Autor:
Nobuki, Sakauchi, Hideki, Furukawa, Junya, Shirai, Ayumu, Sato, Haruhiko, Kuno, Reiko, Saikawa, Masato, Yoshida
Publikováno v:
European journal of medicinal chemistry. 139
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α
Autor:
Tomoya Yukawa, Ikuo Fujimori, Taku Kamei, Yoshihisa Nakada, Nobuki Sakauchi, Masami Yamada, Yusuke Ohba, Hiroyuki Ueno, Maiko Takiguchi, Masako Kuno, Izumi Kamo, Hideyuki Nakagawa, Yasushi Fujioka, Tomoko Igari, Yuji Ishichi, Tetsuya Tsukamoto
Publikováno v:
Bioorganicmedicinal chemistry. 24(14)
Peripherally selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Herein, we describe our medicinal chemistry approach to disc
Autor:
Yumi Imai, Yasuhisa Kohara, Tomohiko Suzaki, Ayumu Sato, Masato Yoshida, Hiroshi Nagabukuro, Nobuki Sakauchi, Haruhiko Kuno, Reiko Saikawa, Hisashi Fujita, Yuichi Okabe, Shigemitsu Imai, Izumi Kamo
Publikováno v:
Journal of medicinal chemistry. 59(7)
A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through screening of an in-house compound library. From i
Autor:
Ikuo Fujimori, Tomoya Yukawa, Taku Kamei, Yoshihisa Nakada, Nobuki Sakauchi, Masami Yamada, Yusuke Ohba, Maiko Takiguchi, Masako Kuno, Izumi Kamo, Hideyuki Nakagawa, Teruki Hamada, Tomoko Igari, Teruaki Okuda, Satoshi Yamamoto, Tetsuya Tsukamoto, Yuji Ishichi, Hiroyuki Ueno
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
Centrally acting noradrenaline reuptake inhibitor (NRI) is reportedly effective for patients with stress urinary incontinence (SUI) by increasing urethral closure in the clinical Phase IIa study with esreboxetine. Noradrenaline transporters are expre