Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Nobuki Nakanishi"'
Autor:
Shu-ichi Okamoto, Olga Prikhodko, Juan Pina-Crespo, Anthony Adame, Scott R. McKercher, Laurence M. Brill, Nobuki Nakanishi, Chang-ki Oh, Tomohiro Nakamura, Eliezer Masliah, Stuart A. Lipton
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 390-397 (2019)
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological, cognitive, and behavioral deficits. TSC patients also express co-morbidity with anxiety a
Externí odkaz:
https://doaj.org/article/a572bd40338d4b15b09c31e72f6e65cb
Autor:
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can
Externí odkaz:
https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
Autor:
Shing Fai Chan, Xiayu Huang, Scott R. McKercher, Rameez Zaidi, Shu-ichi Okamoto, Nobuki Nakanishi, Stuart A. Lipton
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 24-27 (2015)
The myocyte enhancer factor 2 (MEF2) family of transcription factors is highly expressed in the brain and constitutes a key determinant of neuronal survival, differentiation, and synaptic plasticity. However, genome-wide transcriptional profiling of
Externí odkaz:
https://doaj.org/article/73e8eb511c4f452183a4c921aa1f0c04
Autor:
Bo Yang, Mingliang Qu, Rengang Wang, Jon E Chatterton, Xiao-Bo Liu, Bing Zhu, Sonoko Narisawa, Jose Luis Millan, Nobuki Nakanishi, Kathryn Swoboda, Stuart A Lipton, Dongxian Zhang
Publikováno v:
eLife, Vol 4 (2015)
Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lower motor
Externí odkaz:
https://doaj.org/article/6372ba534f6042f3a37c0d0883d048b4
Autor:
Maile A Henson, Rylan S Larsen, Shelikha N Lawson, Isabel Pérez-Otaño, Nobuki Nakanishi, Stuart A Lipton, Benjamin D Philpot
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42327 (2012)
Glutamatergic synapse maturation is critically dependent upon activation of NMDA-type glutamate receptors (NMDARs); however, the contributions of NR3A subunit-containing NMDARs to this process have only begun to be considered. Here we characterized t
Externí odkaz:
https://doaj.org/article/3644addb0ce54e74b054bece7c7b1103
Autor:
Eun-Gyung Cho, Jeffrey D Zaremba, Scott R McKercher, Maria Talantova, Shichun Tu, Eliezer Masliah, Shing Fai Chan, Nobuki Nakanishi, Alexey Terskikh, Stuart A Lipton
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24027 (2011)
Human embryonic stem cells (hESCs) can potentially differentiate into any cell type, including dopaminergic neurons to treat Parkinson's disease (PD), but hyperproliferation and tumor formation must be avoided. Accordingly, we use myocyte enhancer fa
Externí odkaz:
https://doaj.org/article/53ba5c9a0de04197981d40a27e5ed34c
Autor:
Bakker C, Rajesh Ambasudhan, Melissa Luevanos, Pawel Stankiewicz, Abdullah Sultan, Daniel H. Geschwind, Nima Dolatabadi, Riki Kawaguchi, Nicholas J. Schork, Maria Talantova, Michael G. Rosenfeld, Yongwook Choi, Teranaka M, Ivan Garcia-Bassets, Agnes P. Chan, Grabauskas T, James C. Parker, Kozbial P, Swagata Ghatak, Stuart A. Lipton, Shing Fai Chan, Kevin M. Lopez, Nobuki Nakanishi, Noveral Sm, Dorit Trudler
MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d399ffbf3ff7ea7c0988109d1c98e31c
https://doi.org/10.1101/2020.11.19.387639
https://doi.org/10.1101/2020.11.19.387639
Autor:
Shichun Tu, Eliezer Masliah, Nobuki Nakanishi, Scott R. McKercher, Stuart A. Lipton, Yeon-Joo Kang
Publikováno v:
Journal of Molecular Neuroscience. 58:59-65
HIV-associated neurocognitive disorder (HAND) consists of motor and cognitive dysfunction in a relatively large percentage of patients with AIDS. Prior work has suggested that at least part of the neuronal and synaptic damage observed in HAND may occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6ab2634dbb96239b39a334922e18b
https://doi.org/10.1007/s12031-015-0651-1
https://doi.org/10.1007/s12031-015-0651-1
Autor:
Nobuki Nakanishi, Stuart A. Lipton, Rameez Zaidi, Shu-ichi Okamoto, Shing Fai Chan, Xiayu Huang, Scott R. McKercher
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 24-27 (2015)
Genomics Data
Genomics Data
[Briefly describe the contents of the Data in Brief article. Tell the reader the repository and reference number for the data in the abstract to.] The myocyte enhancer factor 2 (MEF2) family of transcription factors is highly expressed in the brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be490fcdeef7009aabe9412669f4415
http://www.sciencedirect.com/science/article/pii/S2213596014001111
http://www.sciencedirect.com/science/article/pii/S2213596014001111
Autor:
Timothy Holland, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Eliezer Masliah, Yuqiang Wang, Alexey V. Terskikh, Vivek Swarup, Huaxi Xu, Xiayu Huang, Mohd Waseem Akhtar, Daniel H. Geschwind, James C. Parker, Scott D. Ryan, Amanda J. Roberts, Shichun Tu, Rosa Maria Escorihuela, Xiaofei Zhang, Nobuki Nakanishi, Neha Bansal, Alejandro Amador-Arjona, Stuart A. Lipton, Shing Fai Chan, Li Yan, Kevin M. Lopez, Robert A. Rissman, Jeffrey D. Zaremba, Daniel R. Holohan
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a166fd27dec67afce13c21feb0e1119
http://europepmc.org/articles/PMC5684358
http://europepmc.org/articles/PMC5684358