Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nobuhito Murai"'
Publikováno v:
Eur J Neurosci
PMC
PMC
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd Microglia are the primary immune cells of the central nervous system and crucial to proper development and maintenance of the brain. Microglia have been recognized to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b67c1a74470f05f4225d3b4eb13883
https://pubmed.ncbi.nlm.nih.gov/32579729
https://pubmed.ncbi.nlm.nih.gov/32579729
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:257-265
Lysophosphatidic acid (LPA) plays an important role in a variety of cellular functions. In particular, LPA5 receptor is highly expressed in spinal cord and dorsal root ganglion, which are associated with pain. This fact prompted us to hypothesize tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725703d1312a1ee066b0cde819b735fa
https://doi.org/10.1016/j.bmc.2017.11.038
https://doi.org/10.1016/j.bmc.2017.11.038
Autor:
Hiromasa Oka, Hideki Hiyama, Toshihiro Sekizawa, Tetsuo Kiso, Toshiaki Aoki, Nobuhito Murai, Tomonari Watabiki
Publikováno v:
Neuropharmacology. 126:97-107
Lysophosphatidic acid (LPA) is a bioactive lipid that acts via at least six G protein-coupled receptors, LPA receptors 1-6 (LPA1-6), for various physiological functions. We examined (1) whether LPA5 is involved in pain signaling in the spinal cord; a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac05ccad456207c87686357248cafc7
https://doi.org/10.1016/j.neuropharm.2017.08.032
https://doi.org/10.1016/j.neuropharm.2017.08.032
Autor:
Nobuhito, Murai, Yuji, Kondo, Shinobu, Akuzawa, Takuma, Mihara, Nobuyuki, Shiraishi, Shuichiro, Kakimoto, Mitsuyuki, Matsumoto
Publikováno v:
European journal of pharmacology. 865
The gamma-aminobutyric acid type B (GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa719fc01420edff4384656b935e7dea
https://pubmed.ncbi.nlm.nih.gov/31647906
https://pubmed.ncbi.nlm.nih.gov/31647906
Autor:
Yuji Kondo, Shuichiro Kakimoto, Nobuhito Murai, Mitsuyuki Matsumoto, Shinobu Akuzawa, Takuma Mihara, Nobuyuki Shiraishi
Publikováno v:
European Journal of Pharmacology. 865:172750
The gamma-aminobutyric acid type B (GABAB) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and fatigue in fibromyalgia (FM) patients. However, the use of GABAB receptor agonists is limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ff7d1628b63b64495ae5bfe528f419
https://doi.org/10.1016/j.ejphar.2019.172750
https://doi.org/10.1016/j.ejphar.2019.172750
Autor:
Jun Sato, Mika Ohmichi, Yusuke Ohmichi, Hidehiro Oshibuchi, Masaya Yasui, Takashi Nakano, Munekazu Naito, Nobuhito Murai, Nobuaki Takeshita
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The aim of this study was to clarify the mechanism of disuse-induced muscle hyperalgesia through the evaluation of the pharmacological behaviour of muscle hyperalgesia profiles in chronic post-cast pain (CPCP) rats with acute and chronic-phase mirror
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62787edb4f616c05172fefb606d1cf79
https://doi.org/10.1038/s41598-018-21429-3
https://doi.org/10.1038/s41598-018-21429-3
Autor:
Nobuya Matsuoka, Nobuaki Takeshita, Nobuhito Murai, Megumi Irie, Toshiaki Aoki, Seiji Tamura, Fusako Nishigaki
Publikováno v:
Neurological Research. 37:525-530
The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake inhibition and analgesic effects in animal models of neuropathic pain. Here, we investigated the analgesic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03605e24e62a95a84e84b5133ab76014
https://doi.org/10.1179/1743132815y.0000000007
https://doi.org/10.1179/1743132815y.0000000007
Autor:
Seiji Tamura, Tomoya Oe, Mina Tsukamoto, Ryugo Enomoto, Nobuya Matsuoka, Toshihiro Sekizawa, Toshiaki Aoki, Nozomu Hamakawa, Nobuhito Murai, Shuichiro Kakimoto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:372-382
AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment of cerebrovascular diseases with multiple pharmacological actions, including serotonin (5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd52a664d862c3f2e29bdbe47db59e4
https://doi.org/10.1124/jpet.113.208686
https://doi.org/10.1124/jpet.113.208686
Publikováno v:
European journal of pharmacology. 810
KCNH3 (BEC1) is a member of the ether-a-go-go (KCNH) family of voltage-gated K+ channels. The aim of this study was to determine the pharmacological profiles in vitro and in vivo of a KCNH3 inhibitor N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd87a8f45204145bbd4af8a81170fc7
https://pubmed.ncbi.nlm.nih.gov/28552344
https://pubmed.ncbi.nlm.nih.gov/28552344