Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Nobuhisa Iwata"'
Autor:
Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) cDNA is overexpressed (1st generation models). Although many of these m
Externí odkaz:
https://doaj.org/article/3983cddf12fe4239a47976b7e939da42
Autor:
Takayuki Kondo, Keiko Imamura, Misato Funayama, Kayoko Tsukita, Michiyo Miyake, Akira Ohta, Knut Woltjen, Masato Nakagawa, Takashi Asada, Tetsuaki Arai, Shinobu Kawakatsu, Yuishin Izumi, Ryuji Kaji, Nobuhisa Iwata, Haruhisa Inoue
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2304-2312 (2017)
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness,
Externí odkaz:
https://doaj.org/article/119fc43eb23c46f4bc742a11a0c112de
Autor:
Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 2, Pp 175-189 (2015)
Abstract The β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1), an essential protease for the generation of amyloid‐β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). However, there is a concern that inhibiting BAC
Externí odkaz:
https://doaj.org/article/fb5d8482b98245c9b451c84618505b64
Autor:
Per Nilsson, Krishnapriya Loganathan, Misaki Sekiguchi, Yukio Matsuba, Kelvin Hui, Satoshi Tsubuki, Motomasa Tanaka, Nobuhisa Iwata, Takashi Saito, Takaomi C. Saido
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 61-69 (2013)
Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in
Externí odkaz:
https://doaj.org/article/d0f37d878e9b41ad88e3270753afdfc7
Autor:
Naoki Yahata, Masashi Asai, Shiho Kitaoka, Kazutoshi Takahashi, Isao Asaka, Hiroyuki Hioki, Takeshi Kaneko, Kei Maruyama, Takaomi C Saido, Tatsutoshi Nakahata, Takashi Asada, Shinya Yamanaka, Nobuhisa Iwata, Haruhisa Inoue
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25788 (2011)
BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from
Externí odkaz:
https://doaj.org/article/199afc03ba1941ce92ffdf2f7109e417
Autor:
Hideko Kokubo, Rakez Kayed, Charles G. Glabe, Matthias Staufenbiel, Takaomi C. Saido, Nobuhisa Iwata, Haruyasu Yamaguchi
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2009 (2009)
Amyloid β (Aβ) annular protofibrils (APFs) have been described where the structure is related to that of β barrel pore-forming bacterial toxins and exhibits cellular toxicity. To investigate the relationship of Aβ APFs to disease and their ultras
Externí odkaz:
https://doaj.org/article/c68cc34428db41e6a25f547f9cadef3c
Autor:
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, Mann, David M. A., Robinson, Andrew C., Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Saido, Takaomi C.
Publikováno v:
Life Science Alliance; Dec2024, Vol. 7 Issue 12, p1-17, 17p
Autor:
Yuma Hori, Kaori Watanabe, Asmaa S. A. Yassen, Keiro Shirotani, Takashi Tanaka, Nobuhisa Iwata
Publikováno v:
Biological and Pharmaceutical Bulletin. 46(3):446-454
The onset of Alzheimer’s disease (AD) is characterized by accumulation of amyloid β peptide (Aβ) in the brain. Neprilysin (NEP) is one of the major Aβ-degrading enzymes. Given findings that NEP expression in the brain declines from the early sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b83eab60633b028d0a4b23bb8e44a5f
https://nagasaki-u.repo.nii.ac.jp/records/28008
https://nagasaki-u.repo.nii.ac.jp/records/28008
Autor:
Keiro Shirotani, Kaori Watanabe, Daisuke Hatta, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Takayuki Kondo, Haruhisa Inoue, Nobuhisa Iwata
Publikováno v:
Genes to Cells. 28:319-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7412b167e8e0ca48d307b03d01c1c21b
https://doi.org/10.1111/gtc.13010
https://doi.org/10.1111/gtc.13010
Publikováno v:
The Journal of Biochemistry. 172:347-353
Variants of triggering receptor expressed on myeloid cells 2 (TREM2) are associated with an increased incidence of Alzheimer’s disease, as well as other neurodegenerative disorders. TREM2 is glycosylated in vitro and in vivo, but the significance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a472711edc37afee9643a88bfc92e7
https://doi.org/10.1093/jb/mvac073
https://doi.org/10.1093/jb/mvac073