Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Nobuhiro Nakamizo"'
γ-Radiolysis of 5-fluorouracil and 5-fluorouridine derivatives having sulfur-containing substituents
Publikováno v:
Journal of Heterocyclic Chemistry. 31:335-339
γ-Radiolysis reactions of eight 5-fluorouracil (5-FU) derivatives having sulfonyl group-containing suhstituents at the 1-position and five 5-fluorouridine (5-FUR) derivatives having thioureido group-containing substituents were studied under the con
Autor:
Tokuyuki Kuroda, Nobuhiro Nakamizo, Makoto Morimoto, Ikuo Matsukuma, Yutaka Osawa, Hiroshi Nishikawa, Yoshio Otsuji, Toru Sugaya, Koji Hisamura, Tadashi Ashizawa
Publikováno v:
Journal of Heterocyclic Chemistry. 31:113-119
A variety of mitomycin C analogs were synthesized from mitomycin A and their biological activities were studied. Mitomycin A (1) underwent nucleophilic displacement reactions involving intramolecular hydrogen migrations upon treatment with nitrogen n
Publikováno v:
Journal of Heterocyclic Chemistry. 31:53-56
The λ-Radiolysis reactions of mitomycin C (1) and its derivatives were studied in the hope of developing a radiation-induced drug (RID). The λ-radiolysis reactions were carried out in aqueous solutions under the condition where hydrated electron (e
Publikováno v:
ChemInform. 24
2′-Deoxy-5-fluorouridine (5-FUdR) derivatives having various types of sulfur-containing substituents at the 5′-O-position were synthesized and their γ-radiolyses were studied in aqueous solutions. The γ-radiolysis of compounds having 1,3-dithio
Autor:
Hiroshi Nishikawa, Yoshio Otsuji, Tokuyuki Kuroda, Makoto Morimoto, Tadashi Ashizawa, Koji Hisamura, Ikuo Matsukuma, Nobuhiro Nakamizo
Publikováno v:
ChemInform. 24
Seventeen compounds having a variety of substituents at the 3- and 5′-positions of 2′-deoxy-5-fluorouridine (5-FUdR) and 5-fluorouridine (5-FUR) were synthesized, and their γ-radiolysis in aqueous solutions were studied. The compounds having thi
Autor:
Nobuhiro Nakamizo, Hiroshi Nishikawa, Koji Hisamura, Ikuo Matsukuma, Tokuyuki Kuroda, Makoto Morimoto, T. Sugaya, Tadashi Ashizawa, Yoshio Otsuji, Y. Osawa
Publikováno v:
ChemInform. 26
Autor:
Hiroshi Nishikawa, Nobuhiro Nakamizo, Koji Hisamura, Tadashi Ashizawa, Ikuo Matsukuma, Makoto Morimoto, Tokuyuki Kuroda, Yoshio Otsuji
Publikováno v:
Journal of Heterocyclic Chemistry. 29:1133-1142
Seventeen compounds having a variety of substituents at the 3- and 5′-positions of 2′-deoxy-5-fluorouridine (5-FUdR) and 5-fluorouridine (5-FUR) were synthesized, and their γ-radiolysis in aqueous solutions were studied. The compounds having thi
Publikováno v:
Journal of Heterocyclic Chemistry. 29:1143-1147
2′-Deoxy-5-fluorouridine (5-FUdR) derivatives having various types of sulfur-containing substituents at the 5′-O-position were synthesized and their γ-radiolyses were studied in aqueous solutions. The γ-radiolysis of compounds having 1,3-dithio
Publikováno v:
Thrombosis Research. 29:197-206
KF4939, 2,2′-dithiobis-(N-2-hydroxypropylbenzamide), is a potent inhibitor of platelet aggregation in vitro in rabbit and human PRP. This agent inhibited both cyclooxygenase product-dependent (collagen and arachidonate) and independent (ADP and thr
Autor:
Yutaka Kasuya, Koki Shigenobu, Nobuhiro Nakamizo, Masayuki Teranishi, Katsuichi Shuto, Kazuhiro Kubo, Hiroyuki Obase, Haruki Takai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 30:474-483
As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only moderate antihypertensive activity in three hypertensive rat models.