Výsledky vyhledávání - "Nobuhiro Miyakoshi"

Strain difference in the susceptibility to clofibrate in male rats

Autor: Takashi Yamoto, Naochika Matsunuma, Sunao Manabe, Nobuhiro Miyakoshi, Yoshihiko Ohashi, Takashi Makita

Publikováno v: Pathophysiology. 3:65-72

Difference among strains in the susceptibility to clofibrate in male rats was clarified. Males of three rat strains (F344, Sprague Dawley (SD), and Wistar Lewis) were treated with clofibrate mixed in the diet for 14 days. Both biochemical analysis (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d476b56b03784f2d899d1bd71c5f9134
https://doi.org/10.1016/0928-4680(95)00056-9

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Effect of carbidopa (MK-486) on the metabolic fate of L-3,4-dihydroxyphenylalanine (L-dopa). I. Effect of carbidopa on the tissue dopa decarboxylase and on the L-dopa-2-14C uptake by the brain in rats

Autor: Kimihiko Nambu, Kenji Kawai, Toru Komai, Hideyo Shindo, Nobuhiro Miyakoshi

Publikováno v: Journal of Pharmacobio-Dynamics. 1:271-280

The inhibitory effect of Carbidopa (MK-486) on L-3, 4-dihydroxyphenylalanine (DOPA) decarboxylase in various tissues including the brain was investigated as well as the distribution of Carbidopa-14C in rats. The increase in the brain uptake of radioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21a187651920cd78143ead5d7ba14c7a
https://doi.org/10.1248/bpb1978.1.271

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LONG TERM ORAL ADMINISTRATION STUDY OF PRAVASTATIN SODIUM TO BEAGLES FOR 104 WEEKS

Autor: Nobuhiro Miyakoshi, Hiroshi Masuda, Chitoshi Tarumi, Kazuo Yamashita, Naochika Matsunuma

Publikováno v: The Journal of Toxicological Sciences. 14:85-101

Pravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25 mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5d8075cf942742aaa9584eb0cdd263
https://doi.org/10.2131/jts.14.supplementi_85

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PRELIMINARY DOSE FINDING STUDY FOR SUBACUTE TOXICOLOGICAL STUDY OF PRAVASTATIN SODIUM IN MONKEYS

Autor: Hiroshi Masuda, Kazuo Yamashita, Nobuhiro Miyakoshi, Naochica Matsunuma, Sunao Manabe, Seiji Sudo

Publikováno v: The Journal of Toxicological Sciences. 14:41-55

Pravastatin sodium was orally administered to cynomolgus monkeys at dosage levels of 50, 200 and 800 mg/kg/day for 7 successive days. Excretion of diarrhea and/or loose stool were observed in the more than 50 mg/kg dose group, but the changes are qui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7cc186299214ad7517270b1007a05c
https://doi.org/10.2131/jts.14.supplementi_41

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Whole-body autoradiographic studies on the distribution of 14C-labeled D- and L-5-hydroxytryptophan, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid in rats

Autor: Nobuhiro Miyakoshi, Hideyo Shindo

Publikováno v: Chemical and Pharmaceutical Bulletin. 24:3158-3168

The distribution of D-and L-isomers of 14C-labeled 5-hydroxytryptophan (5-HTP) was comparatively investigated by means of whole-body autoradiography following intravenous and oral administration to rats. The distribution of 14C-labeled 5-hydroxytrypt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ec46a36fb10e850bf32e38f48e3be0
https://doi.org/10.1248/cpb.24.3158

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Studies on the Metabolism of D-and L-Isomers of 3, 4-Dihydroxyphenylalanine (DOPA). III. Absorption, Distribution and Excretion of D-and L-DOPA-14C in Rats following Intravenous and Oral Administration

Autor: Eiichi Nakajima, Kenji Kawai, Kazuyo Tanaka, Nobuhiro Miyakoshi, Hideyo Shindo

Publikováno v: Chemical and Pharmaceutical Bulletin. 21:817-825

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bd8cf1d1e9d32977b848624e84235bd
https://doi.org/10.1248/cpb.21.817

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Studies on the Metabolism of D- and L-Isomers of 3, 4-Dihydroxyphenylalanine (DOPA). II. Autoradiographic Study on the Distribution of 14C-Labeled D- and L-DOPA after Oral Administration in Rats

Autor: Hideyo Shindo, Eiichi Nakajima, Nobuhiro Miyakoshi

Publikováno v: Chemical and Pharmaceutical Bulletin. 20:966-973

The distribution of D- and L-14C-DOPA following oral administration in rats were investigated by means of whole-body autoradiographic technique. With a constant dose level of 10 mg/kg, the distribution patterns of the two isomers were found to be sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0624ab343ca17ea081f5dcc7ad803bb1
https://doi.org/10.1248/cpb.20.966

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Autoradiographic studies on the distribution of quaternary ammonium compounds. III. Distribution, excretion and metabolism of 14C-labeled pancuronium bromide in rats

Autor: Hideyo Shindo, Eiji Shigehara, Nobuhiro Miyakoshi, Eiichi Nakajima

Publikováno v: Chemicalpharmaceutical bulletin. 22(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f80bd18c4a94c08aa2a01d598366dd0
https://pubmed.ncbi.nlm.nih.gov/4468095

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Subacute toxicological study in monkeys treated orally with pravastatin sodium for 5 weeks

Autor: Naochika Matsunuma, Hisao Tanase, Nobuhiro Miyakoshi, Hiroshi Masuda, Kazuo Yamashita, Sunao Manabe, Seiji Sudo

Publikováno v: The Journal of toxicological sciences. 14

Pravastatin sodium was administered orally to cynomolgus monkeys at dosage levels of 50, 100, 200 and 400 mg/kg/day for 5 successive weeks. Five animals of 200 mg/kg and 400 mg/kg dose groups were sacrificed during the study period, because these ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39ab14b6c70376f916a641de0c43892
https://pubmed.ncbi.nlm.nih.gov/2509725

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