Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Nobuhiro Inatomi"'
Autor:
Takahiro Tanaka, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Yasushi Fujioka, Hidenori Kamiguchi, Masashi Yamaguchi, Akio Imanishi, Makiko Kawamoto, Kasei Miura, Yoichi Nishikawa, Yasuhiro Tsukimi
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 487-495 (2012)
We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to screen tachykinin NK2 receptor (NK2-R) antagonists using pharmacological and pharmacokinetic (PK)/PD analyses. Under urethane anesthesia, changes in intracolonic p
Externí odkaz:
https://doaj.org/article/0806af0bcee4466e990863cb54999d4d
Autor:
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 1, Pp 15-25 (2012)
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist. In this study, we investigated its anta
Externí odkaz:
https://doaj.org/article/7f7e33b0302a467eb8190607814504fa
Publikováno v:
Journal of Pharmacological Sciences, Vol 98, Iss 4, Pp 411-418 (2005)
Stress-induced colonic functional changes have been investigated mainly under conditions involving physical stress, like in the restraint stress model. In this study, we established a new stress-induced defecation model involving the placement of Mon
Externí odkaz:
https://doaj.org/article/fb67501ea2294d338d29a0c1000ea25e
Autor:
Yasunobu Hori, Akio Imanishi, Naoki Tarui, Yasushi Fujioka, Toshihiro Imaeda, Fumio Itoh, Mitsuyo Kondo, Haruyuki Nishida, Koji Ono, Masahiro Kajino, Kazuo Nakai, Nobuhiro Inatomi, Jun Matsukawa, Terufumi Takagi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3719-3735
With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24660c0fa82967a04b22a0fe1f9f9a0
https://doi.org/10.1016/j.bmc.2017.05.012
https://doi.org/10.1016/j.bmc.2017.05.012
Publikováno v:
Digestive Diseases and Sciences. 61:1888-1894
Vonoprazan fumarate (TAK-438) is a novel potassium-competitive acid blocker that appears to exert a longer/more potent antisecretory effect than lansoprazole due to high accumulation/slow clearance from the gastric glands. However, there is no direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9974e4c6d424979c8bb3eac3d0981c4
https://doi.org/10.1007/s10620-016-4100-y
https://doi.org/10.1007/s10620-016-4100-y
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 152(3)
Proton pump inhibitors (PPIs) inhibit H+, K+-ATPase, an enzyme which is the final step of gastric acid secretion and is selectively located in the gastric parietal cells. PPIs block the enzyme in a covalent and irreversible binding manner, thus provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24ecb75fb8a934d8032c29934a7557b
https://pubmed.ncbi.nlm.nih.gov/30185727
https://pubmed.ncbi.nlm.nih.gov/30185727
Publikováno v:
Folia Pharmacologica Japonica. 146:275-282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f7dcf0060018f71a78ac74ebea4ab03
https://doi.org/10.1254/fpj.146.275
https://doi.org/10.1254/fpj.146.275
Autor:
Hideo Fukui, Ikuo Fujimori, Nobuhiro Inatomi, Koji Ono, Keizo Hirase, Haruyuki Nishida, Akio Imanishi, Yasuyoshi Arikawa, Fumio Itoh, Yasunobu Hori, Jun Matsukawa, Kazuo Nakai, Yasushi Fujioka
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to discover a novel excellent potassium-competitive acid blocker (P-CAB) that could perfectly overcome the limitations of proton pump inhibitors (PPIs), we tested various approaches based on pyrrole derivative 1 as a lead compound. As pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc7a1db9c3bce976c446c8b740f5b32
https://pubmed.ncbi.nlm.nih.gov/28483454
https://pubmed.ncbi.nlm.nih.gov/28483454
Autor:
Yasuyoshi Arikawa, Yasushi Fujioka, Motoo Iida, Mitsuyoshi Nishitani, Jun Matsukawa, Toshihiro Imaeda, Teruki Hamada, Yasunobu Hori, Fumio Itoh, Keizo Hirase, Nobuhiro Inatomi, Akio Imanishi, Haruyuki Nishida, Hideo Fukui, Masahiro Kajino
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bac684f5eccfc18c3228e16d7323bb0
https://pubmed.ncbi.nlm.nih.gov/28442261
https://pubmed.ncbi.nlm.nih.gov/28442261
Autor:
Makiko Kawamoto, Fumihiko Sato, Atsushi Hasuoka, Nobuhiro Inatomi, Yasuyoshi Arikawa, Terufumi Takagi, Yasunobu Hori, Masahiro Kajino, Naoki Tarui, Keizo Hirase
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:336-342
A series of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives were designed and synthesized based on our docking model as potassium-competitive acid blockers (P-CABs). Molecular modeling of these derivatives led us to introduce a substituent at the 1-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcc2e6e340e2f6af98b337e5386ddb1
https://doi.org/10.1248/cpb.c13-00878
https://doi.org/10.1248/cpb.c13-00878