Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nobuhiro Fuchi"'
Autor:
Hiroaki Ohno, Zengye Hou, Junfeng Shi, Yamato Suzuki, Yohei Miyamoto, Masateru Yamada, Gozoh Tsujimoto, Nobuhiro Fuchi, Ying Xiao, Keiyu Oshida, Misato Yasue, Yoshinori Takei, Akira Hirasawa, Ning Liu
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:1345-1351
Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we have identified that one catalytic isozyme of CK2, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ee45a0dafa0d2680da654de76d4cce
https://doi.org/10.1248/bpb.b15-00195
https://doi.org/10.1248/bpb.b15-00195
Autor:
Mai Yagi, Yasuhito Nakadera, Eriko Higashi, Yuko Kato, Ayano Watanabe, Hideo Kigoshi, Masateru Yamada, Yutaka Nishimura, Nobuhiro Fuchi, Takumi Aoki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:565-570
We identified 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted ureas as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating chronic kidney diseases. Compound 19 exhibited excellent sEH inhibitory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f110e8b6b0566a6ac2f7f67999d88e
https://doi.org/10.1016/j.bmcl.2013.12.020
https://doi.org/10.1016/j.bmcl.2013.12.020
Autor:
Shinichi Yamaguchi, Kazuharu Suyama, Kazumi Nishimura, Hiroshi Ueda, Yosuke Iura, Masateru Yamada, Toshiya Takahashi, Shigeo Fujii, Nobuhiro Fuchi, Aiko Nitta, Hiroaki Kaneko, Yumiko Sekiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4358-4361
We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was identified, and derivatives were prepared to develop potent inhibitory activity. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b789b97df6e6cb81f046a6f856730e
https://doi.org/10.1016/j.bmcl.2012.05.006
https://doi.org/10.1016/j.bmcl.2012.05.006
Publikováno v:
Synlett. 2002:0285-0289
A facile synthesis of a conformationally restricted β-strand mimetic library is described. Regioselective 1,3-dipolar cycloaddition with a resin-bound vinylsulfone provides a structurally diverse β-strand templated library. This library includes po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1a12fee77863034714e381591594e7
https://doi.org/10.1055/s-2002-19783
https://doi.org/10.1055/s-2002-19783
Autor:
Takayuki Doi, Nobuhiro Fuchi, Takeo Harada, Bolong Cao, Michael Kahn, Jan Urban, Takashi Takahashi
Publikováno v:
Tetrahedron Letters. 42:1305-1308
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c36c77c2edfc86c767b8cc72006620
https://doi.org/10.1016/s0040-4039(00)02229-2
https://doi.org/10.1016/s0040-4039(00)02229-2
Autor:
Masateru Yamada, Eriko Higashi, Yutaka Nishimura, Yuko Kato, Nobuhiro Fuchi, Yasuhito Nakadera, Hajime Saburi, Takumi Aoki, Mai Yagi, Ayano Watanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(21)
We identified 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating hypertension. Docking studies using human and murine sEH X-ray crystal str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6199791d12fbed03619419887e40
https://pubmed.ncbi.nlm.nih.gov/24035338
https://pubmed.ncbi.nlm.nih.gov/24035338
Autor:
Takayuki Doi, Bolong Cao, Nobuhiro Fuchi, Takeo Harada, Michael Kahn, Jan Urban, Takashi Takahashi
Publikováno v:
ChemInform. 32
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb32af3a6fea3ce4e63803d7917bb9ec
https://doi.org/10.1002/chin.200123141
https://doi.org/10.1002/chin.200123141
Autor:
James H. McKerrow, Jonathan A. Ellman, Moumita Debnath, Iain D. Kerr, Patricia S. Doyle, Linda S. Brinen, Kenny K. H. Ang, Kimberly T. Barrett, Katrien Brak, Juan C. Engel, Nobuhiro Fuchi
Publikováno v:
Journal of medicinal chemistry. 53(4)
A century after discovering that the Trypanosoma cruzi parasite is the etiological agent of Chagas disease, treatment is still plagued by limited efficacy, toxicity, and the emergence of drug resistance. The development of inhibitors of the major T.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c1f50720aebef468d2097988f08a35
https://pubmed.ncbi.nlm.nih.gov/20088534
https://pubmed.ncbi.nlm.nih.gov/20088534
Publikováno v:
Chem. Lett.. 34:438-439
1,3-Dipolar cycloaddition of azomethine imines to the polymer-supported vinylsulfone was achieved. Pyrazole derivatives bearing various aryl groups were synthesized regioselectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b644e05f0779e164541c2fdde482b1b
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100392271
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100392271