Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Nobuhiko Yamamoto"'
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103432- (2024)
Summary: Single-molecule imaging (SMI) is a powerful approach to quantify the spatiotemporal dynamics of transcription in living cells. Here, we describe a protocol of SMI for transcription and epigenetic factors in human cortical neurons derived fro
Externí odkaz:
https://doaj.org/article/4fef402219bf485785a462cc6d2fded3
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure b
Externí odkaz:
https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6
Autor:
Leechung Chang, Nobuhiko Yamamoto
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1259-1260 (2023)
Externí odkaz:
https://doaj.org/article/472cc413dab94cd2bbcee7609da36216
Publikováno v:
eLife, Vol 11 (2022)
Neuronal abundance and thickness of each cortical layer are specific to each area, but how this fundamental feature arises during development remains poorly understood. While some of area-specific features are controlled by intrinsic cues such as mor
Externí odkaz:
https://doaj.org/article/366731f39fef4f88beda3e563791d82f
Autor:
Yumi Miyasaka, Nobuhiko Yamamoto
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
During development, cortical circuits are remodeled by spontaneous and sensory-evoked activity via alteration of the expression of wiring molecules. An intriguing question is how physiological neuronal activity modifies the expression of these molecu
Externí odkaz:
https://doaj.org/article/58bcfea96cb644a28cacbc7409ae2679
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method
Externí odkaz:
https://doaj.org/article/a29879fbf344471ebd39d7822a9d2a0b
Autor:
Ricardo Alchini, Haruka Sato, Naoyuki Matsumoto, Tomomi Shimogori, Noriyuki Sugo, Nobuhiko Yamamoto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract During development, thalamocortical (TC) axons form branches in an activity-dependent fashion. Here we investigated how neuronal activity is converted to molecular signals, focusing on an epigenetic mechanism involving histone deacetylases (
Externí odkaz:
https://doaj.org/article/395131c25061436dbca24b8a988bdd92
Autor:
Koji Oishi, Nao Nakagawa, Kashiko Tachikawa, Shinji Sasaki, Michihiko Aramaki, Shinji Hirano, Nobuhiko Yamamoto, Yumiko Yoshimura, Kazunori Nakajima
Publikováno v:
eLife, Vol 5 (2016)
Many cell-intrinsic mechanisms have been shown to regulate neuronal subtype specification in the mammalian neocortex. However, how much cell environment is crucial for subtype determination still remained unclear. Here, we show that knockdown of Prot
Externí odkaz:
https://doaj.org/article/d5f2ee96be5f497d8eda9d159a409556
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82954 (2013)
During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involv
Externí odkaz:
https://doaj.org/article/60d3b03cb56c46c1bd80c63ad526827f
Publikováno v:
J Neurosci
Neuronal remodeling after brain injury is essential for functional recovery. After unilateral cortical lesion, axons from the intact cortex ectopically project to the denervated midbrain, but the molecular mechanisms remain largely unknown. To addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e41a3345fab1d04f26f38f5c4acc81
https://doi.org/10.1523/jneurosci.1371-21.2021
https://doi.org/10.1523/jneurosci.1371-21.2021