Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Nobuhiko Kojima"'
Publikováno v:
Brain and Behavior, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Introduction Olfactory deficit often occurs during the prodromal stage of Alzheimer's disease (AD). Although olfactory deficit is a useful measure for screening AD‐related amnestic disorder, little is known about the cause of this deficit.
Externí odkaz:
https://doaj.org/article/0329f0ff4e4b46ffbb651bfc0804ac57
Autor:
Fumiya Tao, Keita Kitamura, Sanshiro Hanada, Kazuyuki Sugimoto, Tomomi Furihata, Nobuhiko Kojima
Publikováno v:
Bioengineering, Vol 10, Iss 3, p 349 (2023)
Astrocytes, a type of glial cell in the brain, are thought to be functionally and morphologically diverse cells that regulate brain homeostasis. Cell immortalization is a promising technique for the propagation of primary human astrocytes. The immort
Externí odkaz:
https://doaj.org/article/e5cabafd54c841b793846e6e0df6a6c7
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 75-81 (2016)
The regulation of Sertoli cells by some hormones and signaling factors is important for normal spermatogenesis. Notch signaling is considered to be necessary for normal spermatogenesis in mouse. In this study, we revealed two new facts about Sertoli
Externí odkaz:
https://doaj.org/article/a89db324aad045b096287edb7c6c7b13
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 1-6 (2016)
T-box transcription factors play important roles in vertebrate mesoderm formation. Eomesodermin is involved in the initial step of the prospective mesodermal cells recruited near the primitive streak. Then T or Brachyury gene is responsible for gener
Externí odkaz:
https://doaj.org/article/eec4c61b1fd04641af16c70c243f2ddc
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 32-37 (2016)
A three-dimensional (3D) bone marrow (BM) culture system may facilitate research into the molecular mechanisms involved in hematopoiesis and BM diseases. However, because >90% of BM cells are composed of non-adherent blood cells, it is difficult to o
Externí odkaz:
https://doaj.org/article/b2acea978ed544d7b85e9f630311fe8f
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 7-10 (2016)
Introduction: Three-dimensional (3D) multicellular spheroids are useful tools for simulation of cellular functions in vitro. However, it is difficult to culture certain epithelial cell types under 3D spheroid conditions because these cells cannot res
Externí odkaz:
https://doaj.org/article/847c000a36ea40d0bfae3e6ba7c69b6e
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 11-14 (2016)
We have previously reported that multi-cellular heteroaggregates comprising murine pancreatic α (αTC1.6) and β (MIN6-m9) cell lines spontaneously acquired islet-like architecture and displayed higher insulin secretion rates. However, the mechanism
Externí odkaz:
https://doaj.org/article/2c61a9e599d947cd89f05a779115d2ef
Autor:
Hiroki Yasuda, Nobuhiko Kojima, Kenji Hanamura, Hiroyuki Yamazaki, Kenji Sakimura, Tomoaki Shirao
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Drebrin is an actin-binding protein that is preferentially expressed in the brain. It is highly localized in dendritic spines and regulates spine shapes. The embryonic-type (drebrin E) is expressed in the embryonic and early postnatal brain and is re
Externí odkaz:
https://doaj.org/article/af81f4fc9e874d1f8722d71a0c740a2f
Autor:
Imtiaj Hasan, Shigeki Sugawara, Yuki Fujii, Yasuhiro Koide, Daiki Terada, Naoya Iimura, Toshiyuki Fujiwara, Keisuke G. Takahashi, Nobuhiko Kojima, Sultana Rajia, Sarkar M. A. Kawsar, Robert A. Kanaly, Hideho Uchiyama, Masahiro Hosono, Yukiko Ogawa, Hideaki Fujita, Jiharu Hamako, Taei Matsui, Yasuhiro Ozeki
Publikováno v:
Marine Drugs, Vol 13, Iss 12, Pp 7377-7389 (2015)
MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type
Externí odkaz:
https://doaj.org/article/9b592307f83d4dd385fb0138d7fc9dc2
Autor:
Hirotaka Mihara, Mai Kugawa, Kanae Sayo, Fumiya Tao, Marie Shinohara, Masaki Nishikawa, Yasuyuki Sakai, Takeshi Akama, Nobuhiko Kojima
Publikováno v:
Cells, Vol 8, Iss 6, p 525 (2019)
Culture systems for three-dimensional tissues, such as multicellular spheroids, are indispensable for high-throughput screening of primary or patient-derived xenograft (PDX)-expanded cancer tissues. Oxygen supply to the center of such spheroids is pa
Externí odkaz:
https://doaj.org/article/cb4ccefe513e491ab37ed65526132a20