Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Nobuhiko Hiraga"'
Autor:
Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L. Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J. Cotler, Shiro Oka, Kazuaki Chayama, Harel Dahari
Publikováno v:
Virus Research, Vol 349, Iss , Pp 199451- (2024)
Recent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ a
Externí odkaz:
https://doaj.org/article/857a0b4422664920a2039f47a3fe44fd
Autor:
Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immat
Externí odkaz:
https://doaj.org/article/3a32cdc5f1e44ed986f4b68efe536826
Autor:
Atsushi Ono, Akihiro Fujimoto, Yujiro Yamamoto, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Tomokazu Kawaoka, Masataka Tsuge, Hiromi Abe, C. Nelson Hayes, Daiki Miki, Mayuko Furuta, Tatsuhiko Tsunoda, Satoru Miyano, Michiaki Kubo, Hiroshi Aikata, Hidenori Ochi, Yoshi-iku Kawakami, Koji Arihiro, Hideki Ohdan, Hidewaki Nakagawa, Kazuaki Chayama
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 5, Pp 516-534 (2015)
Background & Aims: Circulating tumor DNA (ctDNA) carrying tumor-specific sequence alterations has been found in the cell-free fraction of blood. Liver cancer tumor specimens are difficult to obtain, and noninvasive methods are required to assess canc
Externí odkaz:
https://doaj.org/article/5d4f2abd284a416486976c527b117200
Autor:
Eisuke Miyaki, Nobuhiko Hiraga, Michio Imamura, Takuro Uchida, Hiromi Kan, Masataka Tsuge, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Masahiro Serikawa, Hiroshi Aikata, Hidenori Ochi, Yuji Ishida, Chise Tateno, Hideki Ohdan, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172412 (2017)
Interferon (IFN) inhibits hepatitis C virus (HCV) replication through up-regulation of intrahepatic IFN-stimulated gene expression but also through activation of host immune cells. In the present study, we analyzed the immune cell-mediated antiviral
Externí odkaz:
https://doaj.org/article/908568255e664475b5d4a7789cf08fc1
Autor:
Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005610 (2016)
Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of bot
Externí odkaz:
https://doaj.org/article/82f86812cc4942c3ba53cd436458afb0
Autor:
Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130022 (2015)
Daclatasvir and asunaprevir dual oral therapy is expected to achieve high sustained virological response (SVR) rates in patients with HCV genotype 1b infection. However, presence of the NS5A-Y93H substitution at baseline has been shown to be an indep
Externí odkaz:
https://doaj.org/article/d27d58d499974b428567fea3e7c37fb7
Autor:
Daiki Miki, Hidenori Ochi, Atsushi Takahashi, C Nelson Hayes, Yuji Urabe, Hiromi Abe, Tomokazu Kawaoka, Masataka Tsuge, Nobuhiko Hiraga, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Shoichi Takahashi, Norio Akuta, Fumitaka Suzuki, Kenji Ikeda, Hiromitsu Kumada, Yoshiyasu Karino, Joji Toyota, Tatsuhiko Tsunoda, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84226 (2013)
Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the effect of human leukocyte antigen (HLA) on viral persistence because of its critical role in the immune response against exp
Externí odkaz:
https://doaj.org/article/2c78959bc1ab4ec9b4fa8debe83af7f5
Autor:
C Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Rie Akiyama, Hiromi Abe, Hidenori Ochi, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Hiroshi Aikata, Tomokazu Kawaoka, Yoshiiku Kawakami, Waka Ohishi, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47490 (2012)
UNLABELLED:Disease-specific serum miRNA profiles may serve as biomarkers and might reveal potential new avenues for therapy. An HBV-specific serum miRNA profile associated with HBV surface antigen (HBsAg) particles has recently been reported, and AGO
Externí odkaz:
https://doaj.org/article/f8b6010c4cbf43c8a64263036f4511a3
Autor:
Masataka Tsuge, Yoshifumi Fujimoto, Nobuhiko Hiraga, Yizhou Zhang, Mayu Ohnishi, Tomohiko Kohno, Hiromi Abe, Daiki Miki, Michio Imamura, Shoichi Takahashi, Hidenori Ochi, C Nelson Hayes, Fuyuki Miya, Tatsuhiko Tsunoda, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23856 (2011)
BACKGROUND AND AIMS: Recent studies indicate that hepatitis C virus (HCV) can modulate the expression of various genes including those involved in interferon signaling, and up-regulation of interferon-stimulated genes by HCV was reported to be strong
Externí odkaz:
https://doaj.org/article/64f93647bbed4190b2807bd64c5bc1ac
Autor:
Atesmachew Hailegiorgis, Yuji Ishida, Nicholson Collier, Michio Imamura, Zhenzhen Shi, Vladimir Reinharz, Masataka Tsuge, Danny Barash, Nobuhiko Hiraga, Hiroshi Yokomichi, Chise Tateno, Jonathan Ozik, Susan L. Uprichard, Kazuaki Chayama, Harel Dahari
Serum hepatitis B virus (HBV) kinetics in urokinase-type plasminogen activator/severe combined immunodeficient (uPA-SCID) mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03147e2df60c7f95ae916c87b5be746c
https://doi.org/10.1101/2022.01.30.478385
https://doi.org/10.1101/2022.01.30.478385
