Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Nobuhiko Hiraga"'
Autor:
Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immat
Externí odkaz:
https://doaj.org/article/3a32cdc5f1e44ed986f4b68efe536826
Autor:
Eisuke Miyaki, Nobuhiko Hiraga, Michio Imamura, Takuro Uchida, Hiromi Kan, Masataka Tsuge, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Masahiro Serikawa, Hiroshi Aikata, Hidenori Ochi, Yuji Ishida, Chise Tateno, Hideki Ohdan, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172412 (2017)
Interferon (IFN) inhibits hepatitis C virus (HCV) replication through up-regulation of intrahepatic IFN-stimulated gene expression but also through activation of host immune cells. In the present study, we analyzed the immune cell-mediated antiviral
Externí odkaz:
https://doaj.org/article/908568255e664475b5d4a7789cf08fc1
Autor:
Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005610 (2016)
Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of bot
Externí odkaz:
https://doaj.org/article/82f86812cc4942c3ba53cd436458afb0
Autor:
Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130022 (2015)
Daclatasvir and asunaprevir dual oral therapy is expected to achieve high sustained virological response (SVR) rates in patients with HCV genotype 1b infection. However, presence of the NS5A-Y93H substitution at baseline has been shown to be an indep
Externí odkaz:
https://doaj.org/article/d27d58d499974b428567fea3e7c37fb7
Autor:
Daiki Miki, Hidenori Ochi, Atsushi Takahashi, C Nelson Hayes, Yuji Urabe, Hiromi Abe, Tomokazu Kawaoka, Masataka Tsuge, Nobuhiko Hiraga, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Shoichi Takahashi, Norio Akuta, Fumitaka Suzuki, Kenji Ikeda, Hiromitsu Kumada, Yoshiyasu Karino, Joji Toyota, Tatsuhiko Tsunoda, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84226 (2013)
Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the effect of human leukocyte antigen (HLA) on viral persistence because of its critical role in the immune response against exp
Externí odkaz:
https://doaj.org/article/2c78959bc1ab4ec9b4fa8debe83af7f5
Autor:
Masataka Tsuge, Yoshifumi Fujimoto, Nobuhiko Hiraga, Yizhou Zhang, Mayu Ohnishi, Tomohiko Kohno, Hiromi Abe, Daiki Miki, Michio Imamura, Shoichi Takahashi, Hidenori Ochi, C Nelson Hayes, Fuyuki Miya, Tatsuhiko Tsunoda, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23856 (2011)
BACKGROUND AND AIMS: Recent studies indicate that hepatitis C virus (HCV) can modulate the expression of various genes including those involved in interferon signaling, and up-regulation of interferon-stimulated genes by HCV was reported to be strong
Externí odkaz:
https://doaj.org/article/64f93647bbed4190b2807bd64c5bc1ac
Autor:
Atesmachew Hailegiorgis, Yuji Ishida, Nicholson Collier, Michio Imamura, Zhenzhen Shi, Vladimir Reinharz, Masataka Tsuge, Danny Barash, Nobuhiko Hiraga, Hiroshi Yokomichi, Chise Tateno, Jonathan Ozik, Susan L. Uprichard, Kazuaki Chayama, Harel Dahari
Serum hepatitis B virus (HBV) kinetics in urokinase-type plasminogen activator/severe combined immunodeficient (uPA-SCID) mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03147e2df60c7f95ae916c87b5be746c
https://doi.org/10.1101/2022.01.30.478385
https://doi.org/10.1101/2022.01.30.478385
Autor:
Daiki Miki, Hidenori Ochi, Kazuaki Chayama, Clair Nelson Hayes, Yuko Nagaoki, Hiromi Abe-Chayama, Tomokazu Kawaoka, Hideyuki Hyogo, Masataka Tsuge, Mutsumi Miyauchi, Hidemi Kurihara, Michio Imamura, Hisako Furusho, Takashi Takata, Takashi Nakahara, Yoshiiku Kawakami, Nobuhiko Hiraga, Koji Arihiro, Hiroshi Aikata, Tomoaki Shintani, Atsushi Ono, Akira Hiramatsu
Publikováno v:
Journal of Gastroenterology. 53:269-280
The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect o
Autor:
Hiromi Kan, Takuro Uchida, Hiromi Abe-Chayama, Chise Tateno, Hiroshi Aikata, Masataka Tsuge, Grace Naswa Makokha, Nobuhiko Hiraga, Hidenori Ochi, C. Nelson Hayes, Michio Imamura, Daiki Miki, Kazuaki Chayama, Yuji Ishida
Publikováno v:
Journal of General Virology. 98:1040-1047
Urokinase-type plasminogen activator/severe combined immunodeficiency (uPA/SCID) mice transplanted with human hepatocytes are permissive for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. However, one of the problems affecting uPA tra
Autor:
Grace Naswa Makokha, Masataka Tsuge, Kazuaki Chayama, Hidenori Ochi, Hiromi Kan, Hiroshi Aikata, Takuro Uchida, Chise Tateno, Michio Imamura, C. Nelson Hayes, Yuji Ishida, Sajeda Chowdhury, Hiromi Abe, Nobuhiko Hiraga, Daiki Miki
Publikováno v:
Journal of Infectious Diseases. 214:1687-1694
BACKGROUND Although treatment-emergent NS3/4A protease inhibitor (PI)-resistant variants typically decrease in frequency after cessation of PI therapy in patients with chronic hepatitis C virus (HCV) infection, HCV susceptibility to PIs in patients w