Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Nobuhiko Yui"'
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 223 (2024)
We previously reported that acid-degradable methylated β-cyclodextrins (Me-β-CDs)-threaded polyrotaxanes (Me-PRXs) can induce autophagic cell death through endoplasmic reticulum (ER) stress-related autophagy, even in apoptosis-resistant cells. Henc
Externí odkaz:
https://doaj.org/article/bc3f57241a38435087610485a4102c34
Publikováno v:
Science and Technology of Advanced Materials, Vol 22, Iss 1, Pp 494-510 (2021)
To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, we investigated the effect of carboxylation of β-CD PRXs on intracellular uptake. In this
Externí odkaz:
https://doaj.org/article/d6a930a532014e618874c0ff6469a68e
Autor:
Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana V. Kirichenko, Alexander N. Orekhov, Nobuhiko Yui, Ichiro Manabe, Yumiko Oishi
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Recent studies have shown that cellular metabolism is tightly linked to the regulation of immune cells. Here, we show that activation of cholesterol metabolism, involving cholesterol uptake, synthesis, and autophagy/lipophagy, is integral to innate i
Externí odkaz:
https://doaj.org/article/5c9bc3d0a470412caf7bf83b653de058
Autor:
Yuma Yamada, Shinnosuke Daikuhara, Atsushi Tamura, Kei Nishida, Nobuhiko Yui, Hideyoshi Harashima
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 903 (2023)
Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (M
Externí odkaz:
https://doaj.org/article/c83d9795d45b4ad0846c9d6569a756bf
Publikováno v:
Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-8 (2020)
Abstract The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are supramolecular assemblies, whic
Externí odkaz:
https://doaj.org/article/4ad15ca2636f49a799af1d3d1cd3dd6a
Publikováno v:
Molecules, Vol 28, Iss 6, p 2517 (2023)
Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers capable of releasing drugs in acidic cellular environments. Acid-degradable PRXs composed of α-cyclodextrin (α-CD) as a cyclic molecule,
Externí odkaz:
https://doaj.org/article/6843ab18650446ef980a508d06e0ecb4
Publikováno v:
Biomacromolecules. 24:2327-2341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87da7097a8f094bed06cc34d2cff234c
https://doi.org/10.1021/acs.biomac.3c00194
https://doi.org/10.1021/acs.biomac.3c00194
Autor:
Atsushi Tamura, Tae Woong Kang, Asato Tonegawa, Yoshinori Arisaka, Hiroki Masuda, Ryo Mikami, Takanori Iwata, Tetsuya Yoda, Nobuhiko Yui
Publikováno v:
Biomacromolecules. 23:4860-4871
Polyrotaxanes (PRXs) containing acetylated α-cyclodextrins exhibit a temperature-dependent phase transition in aqueous solutions across their lower critical solution temperature (LCST) of approximately 26.6 °C. To gain insights into the interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3203946689183d9599a8ddbb0c52ac
https://doi.org/10.1021/acs.biomac.2c01043
https://doi.org/10.1021/acs.biomac.2c01043
Autor:
Masahiro Hakariya, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Atsushi Tamura, Takanori Iwata, Nobuhiko Yui
Publikováno v:
Gels, Vol 7, Iss 4, p 168 (2021)
Hydrogels are promising materials in tissue engineering scaffolds for healing and regenerating damaged biological tissues. Previously, we developed supramolecular hydrogels using polyrotaxane (PRX), consisting of multiple cyclic molecules threaded by
Externí odkaz:
https://doaj.org/article/a4ce1c6d60c6469da0b9aa866a3e4d8f
Autor:
Yoshihiro, Yoshikawa, Atsushi, Tamura, Susumu, Tsuda, Eisuke, Domae, Shunyao, Zhang, Nobuhiko, Yui, Takashi, Ikeo, Tatsuya, Yoshizawa
Publikováno v:
Dental Materials Journal. 41:624-632
Recently, the potential of β-cyclodextrin-thread acid-degradable polyrotaxane (AdPRX) has been emphasized as a therapeutic agent for cholesterol-related metabolic disorders. In this study, we investigated whether carboxymethyl carbamate-modified AdP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e38e2b1067f5fc94be7641f4506b23
https://doi.org/10.4012/dmj.2021-331
https://doi.org/10.4012/dmj.2021-331