Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Nobuhiko, Ohno"'
Autor:
Yasuyuki Osanai, Yao Lulu Xing, Shinya Mochizuki, Kenta Kobayashi, Jihane Homman-Ludiye, Amali Cooray, Jasmine Poh, Ayumu Inutsuka, Nobuhiko Ohno, Tobias D. Merson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101288- (2024)
Molecular cloning techniques enabling contemporaneous expression of two or more protein-coding sequences provide an invaluable tool for understanding the molecular regulation of cellular functions. The Cre-lox system is used for inducing the expressi
Externí odkaz:
https://doaj.org/article/58ba34fea2c24f2c9fe996aecdcdaad2
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
Autor:
Mami Matsumoto, Katsuyoshi Matsushita, Masaya Hane, Chentao Wen, Chihiro Kurematsu, Haruko Ota, Huy Bang Nguyen, Truc Quynh Thai, Vicente Herranz-Pérez, Masato Sawada, Koichi Fujimoto, José Manuel García-Verdugo, Koutarou D Kimura, Tatsunori Seki, Chihiro Sato, Nobuhiko Ohno, Kazunobu Sawamoto
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1228-1253 (2024)
Abstract In the injured brain, new neurons produced from endogenous neural stem cells form chains and migrate to injured areas and contribute to the regeneration of lost neurons. However, this endogenous regenerative capacity of the brain has not yet
Externí odkaz:
https://doaj.org/article/38a75c2192bc4cdea63491e9304280eb
Autor:
Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A. Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and function
Externí odkaz:
https://doaj.org/article/eb78cdc0f8c54c43a0de1c4a96db4c3e
Autor:
Akihiko Miyauchi, Chika Watanabe, Naoya Yamada, Eriko F. Jimbo, Mizuki Kobayashi, Natsumi Ohishi, Atsuko Nagayoshi, Shiho Aoki, Yoshihito Kishita, Akira Ohtake, Nobuhiko Ohno, Masafumi Takahashi, Takanori Yamagata, Hitoshi Osaka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Originally, apomorphine was a broad-spectrum dopamine agonist with an affinity for all subtypes of the Dopamine D1 receptor to the D5 receptor. We previously identified apomorphine as a potential therapeutic agent for mitochondrial diseases
Externí odkaz:
https://doaj.org/article/4c4ab5e04fb84b9b860c3d9589244955
Autor:
Takayuki Onai, Noritaka Adachi, Hidetoshi Urakubo, Fumiaki Sugahara, Toshihiro Aramaki, Mami Matsumoto, Nobuhiko Ohno
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108338- (2023)
Summary: The cranial muscle is a critical component in the vertebrate head for a predatory lifestyle. However, its evolutionary origin and possible segmental nature during embryogenesis have been controversial. In jawed vertebrates, the presence of p
Externí odkaz:
https://doaj.org/article/27de3e14778a4e829162f97a0b694c92
Autor:
Batpurev Battulga, Kazuhiro Shiizaki, Yutaka Miura, Yasuyuki Osanai, Reiji Yamazaki, Yoshiaki Shinohara, Yoshiyuki Kubota, Toru Hara, Makoto Kuro-o, Nobuhiko Ohno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Calcium phosphate forms particles under excessive urinary excretion of phosphate in the kidney. While the formation of calcium phosphate particles (CaPs) has been implicated in the damage to renal tubular cells and renal dysfunction, clarify
Externí odkaz:
https://doaj.org/article/fddb7b93816940fa872bab55680acdd8
Autor:
Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression. In the mature cerebellum, CTCF is highly expressed in Purkinje
Externí odkaz:
https://doaj.org/article/a72517b6649347dfb51706d49c79da9c
Publikováno v:
Brazilian Journal of Cardiovascular Surgery, Vol 37, Iss spe1, Pp 49-56 (2022)
ABSTRACT Introduction: Improved long-term patency of the no-touch (NT) saphenous vein graft has been reported to result from the preservation of a healthy vascular microstructure, especially endothelial cells. However, the precise morphology of endot
Externí odkaz:
https://doaj.org/article/e3079bfcdc4b444abe30906020d2dbfa
Autor:
Sachiko Sasajima, Masaki Kondo, Nobuhiko Ohno, Tomoyo Ujisawa, Mikio Motegi, Tomohide Hayami, Saeko Asano, Emi Asano-Hayami, Hiromi Nakai-Shimoda, Rieko Inoue, Yuichiro Yamada, Emiri Miura-Yura, Yoshiaki Morishita, Tatsuhito Himeno, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Makoto Tominaga
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Diabetic peripheral neuropathy (DPN) includes symptoms of thermosensory impairment, which are reported to involve changes in the expression or function, or both, of nociceptive TRPV1 and TRPA1 channels in rodents. In the present study, we di
Externí odkaz:
https://doaj.org/article/6fa6fde098624c8097f825048009b79a
Autor:
Yuka Nakamura, Miyuki Kurabe, Mami Matsumoto, Tokiharu Sato, Satoshi Miyashita, Kana Hoshina, Yoshinori Kamiya, Kazuki Tainaka, Hitoshi Matsuzawa, Nobuhiko Ohno, Masaki Ueno
Publikováno v:
eLife, Vol 12 (2023)
Cerebrospinal fluid-contacting neurons (CSF-cNs) are enigmatic mechano- or chemosensory cells lying along the central canal of the spinal cord. Recent studies in zebrafish larvae and lampreys have shown that CSF-cNs control postures and movements via
Externí odkaz:
https://doaj.org/article/59b23486afb94b8ca0b10354836b10a1