Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Nobuaki YOSHIDA"'
Autor:
Kenta Horie, Hiroki Sasanuma, Takashi Kudo, Shin-ichiro Fujita, Maki Miyauchi, Takahisa Miyao, Takao Seki, Nobuko Akiyama, Yuki Takakura, Miki Shimbo, Hyojung Jeon, Masaki Shirakawa, Dai Shiba, Nobuaki Yoshida, Masafumi Muratani, Satoru Takahashi, Taishin Akiyama
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Secondary lymphoid organs are critical for regulating acquired immune responses. The aim of this study was to characterize the impact of spaceflight on secondary lymphoid organs at the molecular level. We analysed the spleens and lymph nodes
Externí odkaz:
https://doaj.org/article/e20455f99c9a4ddcbb21f6fed3409fee
Publikováno v:
The Journal of Reproduction and Development, Vol 65, Iss 1, Pp 37-46 (2018)
Polypyrimidine tract-binding protein 1 (PTBP1) is a highly conserved RNA-binding protein that is a well-known regulator of alternative splicing. Testicular tissue is one of the richest tissues with respect to the number of alternative splicing mRNA i
Externí odkaz:
https://doaj.org/article/e34ff74e06064549bcc47e2d1a3e398e
Autor:
Ryutaro Fukui, Chikako Yamamoto, Fumi Matsumoto, Masahiro Onji, Takuma Shibata, Yusuke Murakami, Atsuo Kanno, Takuto Hayashi, Natsuko Tanimura, Nobuaki Yoshida, Kensuke Miyake
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain.
Externí odkaz:
https://doaj.org/article/098608ff306f4bcd8e80e8f7fd73df85
Autor:
Manabu Ozawa, Eri Kawakami, Reiko Sakamoto, Takayuki Shibasaki, Akiteru Goto, Nobuaki Yoshida
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 75-87 (2014)
Two distinct types of embryonic pluripotent stem cells can be established from either the inner cell mass (ICM) of preimplantation blastocyst (leukemia inhibitory factor (LIF)-dependent embryonic stem cell, ESC, called naive state) or the epiblast of
Externí odkaz:
https://doaj.org/article/cb7da2f0d13248c6a4b2d49a19390649
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150521 (2016)
Phospholipase Cγ2 (PLCγ2)-deficient mice exhibit misconnections of blood and lymphatic vessels, and male infertility. However, the cell type responsible for vascular partitioning and the mechanism for male infertility remain unknown. Accordingly, w
Externí odkaz:
https://doaj.org/article/51e44145087844ad9889324cd3450b65
Autor:
Ryosuke Tateishi, Nobuko Akiyama, Maki Miyauchi, Riko Yoshinaga, Hiroki Sasanuma, Takashi Kudo, Miki Shimbo, Masahiro Shinohara, Koji Obata, Jun-Ichiro Inoue, Masaki Shirakawa, Dai Shiba, Hiroshi Asahara, Nobuaki Yoshida, Satoru Takahashi, Hironobu Morita, Taishin Akiyama
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141650 (2015)
Gravity change affects many immunological systems. We investigated the effects of hypergravity (2G) on murine thymic cells. Exposure of mice to 2G for three days reduced the frequency of CD4+CD8+ thymocytes (DP) and mature medullary thymic epithelial
Externí odkaz:
https://doaj.org/article/471065e0b66040879cf5ba7226e4582c
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125119 (2015)
The level of drebrin, an evolutionarily conserved f-actin-binding protein that regulates synaptic structure and function, is reduced in the brains of patients with chronic neurodegenerative diseases such as Alzheimer's disease (AD) and Down's syndrom
Externí odkaz:
https://doaj.org/article/594b91d7c16a4073b07277f2f36d3ad2
Autor:
Hideaki Okura, Shintaro Sato, Sari Kishikawa, Satoshi Kaneto, Tomoki Nakashima, Nobuaki Yoshida, Hiroshi Takayanagi, Hiroshi Kiyono
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108294 (2014)
The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia.
Externí odkaz:
https://doaj.org/article/3979695b6b2c4b3e839c7fc87589541d
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51639 (2012)
Modulation of VEGFR-3 expression is important for altering lymphatic endothelial cell (LEC) characteristics during the lymphangiogenic processes that occur under developmental, physiological, and pathological conditions. However, the mechanisms under
Externí odkaz:
https://doaj.org/article/3345cd8282ef4d2998a3efbfb2ab747d
Autor:
Koichi Matsuda, Yusuke Nakamura, Nobuaki Yoshida, Hidewaki Nakagawa, Koji Ueda, Chizu Tanikawa
Upon a wide range of cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes related to apoptosis, cell cycle arrest, and DNA repair. However, its involvement in posttransla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b521beca2ec65afb86f79d02530c330
https://doi.org/10.1158/0008-5472.c.6500334
https://doi.org/10.1158/0008-5472.c.6500334