Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Nobuaki Taniguchi"'
Autor:
Naoto Hama, John L. Wood, Nobuaki Taniguchi, Joyce C. Leung, Graham K. Murphy, Ivar M. McDonald, Tatsuya Shirahata, David A. Spiegel, Aaron A. Bedermann, Travis C. McMahon, Christopher M. Schneider, Ping Dong, Nancy Tao, Munenori Inoue, Jon T. Njardarson, Barry M. Twenter, Brian M. Stoltz
Publikováno v:
Angewandte Chemie. 130:2009-2012
Described herein is a synthetic strategy for the total synthesis of (±)-phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels-Alde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7eb01021b7c3f45cf10b171a76e43bc
https://doi.org/10.1002/ange.201712369
https://doi.org/10.1002/ange.201712369
Autor:
Nobuaki Taniguchi, Junko Tsukada, Takeshi Suzuki, Toshiyuki Kusayama, Masayuki Shibasaki, Atsuo Tahara, Yuichi Tomura, Kazuhiro Momose, Takeyuki Yatsu
Publikováno v:
Pharmacology. 78:81-90
Vasopressin (AVP) causes mesangial cell contraction, proliferation and hypertrophy. The present study investigated the effects of YM218, a potent, nonpeptide AVP V1A receptor-selective antagonist, on rat mesangial cells using binding, signal transduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b948c6064bf23f2c19fc0f1019f9d293
https://doi.org/10.1159/000095698
https://doi.org/10.1159/000095698
Autor:
Isao Kinoyama, Eiji Kawanimani, Masafumi Kudoh, Masakazu Imamura, Akira Matsuhisa, Eisuke Nozawa, Shin-ichi Tsukamoto, Nobuaki Taniguchi, Kiyohiro Samizu, Minoru Okada, Mitsuaki Ohta, Tatsuya Niimi, Noritaka Hamada, Hiroshi Koutoku, Takashi Kamikubo, Akira Toyoshima, Takashi Furutani
Publikováno v:
Journal of Medicinal Chemistry. 49:716-726
A novel series of trans-N-aryl-2,5-dimethylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic effects were evaluated. Pharmacological assays indicated that compound 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03578044ecf40c7e35c9ab637ee5e42f
https://doi.org/10.1021/jm050293c
https://doi.org/10.1021/jm050293c
Autor:
Shigeaki Kato, Saya Ito, Takashi Furutani, Hisataka Shikama, Masafumi Kudoh, Masahiko Tanabe, Ken-ichi Takeyama, Hiroshi Koutoku, Masayuki Shibasaki, Eriko Suzuki, Nobuaki Taniguchi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:545-552
Androgen receptor (AR) plays key roles in various biological events, including pathological processes such as prostate cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy (SBMA). SBMA is caused by mutation of the expanded po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7527af05f2a568df2bffea32f253b351
https://doi.org/10.1124/jpet.105.087643
https://doi.org/10.1124/jpet.105.087643
Autor:
Nobuaki Taniguchi, Junko Tsukada, Hiroaki Akane, Yoshiaki Shimada, K. Kikuchi, Yuichi Tomura, Akihiro Tanaka, Akira Matsuhisa, Noriyuki Kawano, Atsuo Tahara, Takashi Tsunoda, Koh-ichi Wada, Toshiyuki Kusayama, Takeyuki Yatsu
Publikováno v:
Chemical and Pharmaceutical Bulletin. 53:764-769
To find a new series of arginine vasopressin (AVP) V1A receptor antagonists, the influence of the 2-phenyl group of 2-phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide (7) was investigated. Replacement of the 2-phenyl group by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f162f1f16e890b86c6ab404fff6bcb12
https://doi.org/10.1248/cpb.53.764
https://doi.org/10.1248/cpb.53.764
Autor:
Noe Ishii, Junko Tsukada, Atsuo Tahara, Koh-ichi Wada, Nobuaki Taniguchi, Akihiro Tanaka, Takeyuki Yatsu, Wataru Uchida, Toshiyuki Kusayama, Yuichi Tomura
Publikováno v:
Pharmacology. 67:106-112
To elucidate the role of arginine vasopressin (AVP) in a hypertensive state, the characteristics of renal cortex V1A and medulla V2 receptors in young spontaneously hypertensive rats (SHR) during the developmental phase of hypertension were compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1a6edc8de621668287366711677775
https://doi.org/10.1159/000067743
https://doi.org/10.1159/000067743
Autor:
Atsuo Tahara, Koh-ichi Wada, Akihiro Tanaka, Nobuaki Taniguchi, Noe Ishii, Yuichi Tomura, Toshiyuki Kusayama, Junko Tsukada, Wataru Uchida, Takeyuki Yatsu
Publikováno v:
Journal of Hypertension. 20:1807-1814
Objective To investigate the effects of YM471, a non-peptide arginine vasopressin (AVP) VIA and V 2 receptor antagonist, on the AVP-induced growth responses in human vascular smooth muscle cells (VSMCs). Methods Binding of YM471 to VIA receptors on V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552688fa76e7923423e29865f17354b0
https://doi.org/10.1097/00004872-200209000-00026
https://doi.org/10.1097/00004872-200209000-00026
Autor:
Yuichi Tomura, Junko Tsukada, Atsuo Tahara, Koh-ichi Wada, Akihiro Tanaka, Noe Ishii, Nobuaki Taniguchi, Takeyuki Yatsu, Toshiyuki Kusayama, Wataru Uchida
Publikováno v:
British Journal of Pharmacology. 133:746-754
YM471, (Z)-4′-{4,4-difluoro-5-[2-(4-dimethylaminopiperidino)-2-oxoethylidene]-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl}-2-phenylbenzanilide monohydrochloride, is a newly synthesized potent vasopressin (AVP) receptor antagonist. Its effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b16dd2651c649b009534cec60d2d450
https://doi.org/10.1038/sj.bjp.0704117
https://doi.org/10.1038/sj.bjp.0704117
Autor:
Tsutomu Tanikawa, Yasushi Kawakami, Yoshihiro Iwaki, Nobuaki Taniguchi, Akihiko Uchida, Yoshihiko Murata
Publikováno v:
Medical Entomology and Zoology. 51:95-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd28788dd2901882980effe59600bd6
https://doi.org/10.7601/mez.51.95
https://doi.org/10.7601/mez.51.95
Publikováno v:
The Journal of Physiology. 524:195-204
To address questions of whether long-term depression (LTD) in the visual cortex is expressed in pre- or postsynaptic sites, whether brain-derived neurotrophic factor (BDNF) exerts its LTD-blocking action without involvement of GABAergic inhibition, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393a8382aa9642e297c97a6612a786a9
https://doi.org/10.1111/j.1469-7793.2000.t01-2-00195.x
https://doi.org/10.1111/j.1469-7793.2000.t01-2-00195.x