Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Nobuaki Shiraki"'
Autor:
Yumeng Wu, Tatsuya Yano, Takayuki Enomoto, Atena Endo, Seiji Okada, Kimi Araki, Nobuaki Shiraki, Shoen Kume
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Type 1 diabetes mellitus (T1DM) affects 8.4 million people worldwide, with patients primarily relying on exogenous insulin injections to maintain blood glucose levels. Islet transplantation via the portal vein has allowed for the direct internal rele
Externí odkaz:
https://doaj.org/article/3ee0e64877004664bcd634a32b71e517
Publikováno v:
FEBS Open Bio, Vol 13, Iss 8, Pp 1405-1414 (2023)
Wolfram syndrome is a monogenic disease mainly caused by mutations in the WFS1 gene. Mutations in the WFS1 gene give rise to diabetes. Here, we characterized mutant WFS1 proteins by studying the stability of full‐length wild‐type (WT) WFS1, a mis
Externí odkaz:
https://doaj.org/article/50d1e9465cc64119b0b5f9c148a15311
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Primary Human Hepatocyte (PHH) remains undefeated as the gold standard in hepatic studies. Despite its valuable properties, partial attachment loss due to the extraction process and cryopreservation remained the main hurdle in its applicatio
Externí odkaz:
https://doaj.org/article/51fa1f23ba6a491b8fe53b6bf32dd11c
Autor:
Kenta Ouchi, Kaori Isono, Yuki Ohya, Nobuaki Shiraki, Masayoshi Tasaki, Yukihiro Inomata, Mitsuharu Ueda, Takumi Era, Shoen Kume, Yukio Ando, Hirofumi Jono
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24590- (2024)
Hereditary transthyretin (TTR) amyloidosis (ATTRv amyloidosis) is autosomal dominant and caused by mutation of TTR gene. Heterozygous ATTR Tyr114Cys (p.Tyr134Cys) amyloidosis is a lethal disease with a life expectancy of about 10 years after onset of
Externí odkaz:
https://doaj.org/article/a449e521100b47aebc43f6901a9e738b
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 4, Pp 522-524 (2023)
Externí odkaz:
https://doaj.org/article/92f661f8c1b84f579d9a886415ad79bb
Publikováno v:
Biology Open, Vol 12, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/70400ebc61374cd09428566569909179
Autor:
Marie Shinohara, Hiroshi Arakawa, Yuuichi Oda, Nobuaki Shiraki, Shinji Sugiura, Takumi Nishiuchi, Taku Satoh, Keita Iino, Sylvia Leo, Yusuke Kato, Karin Araya, Takumi Kawanishi, Tomoki Nakatsuji, Manami Mitsuta, Kosuke Inamura, Tomomi Goto, Kenta Shinha, Wataru Nihei, Kikuo Komori, Masaki Nishikawa, Shoen Kume, Yukio Kato, Toshiyuki Kanamori, Yasuyuki Sakai, Hiroshi Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Examining intestine–liver interactions is important for achieving the desired physiological drug absorption and metabolism response in in vitro drug tests. Multi-organ microphysiological systems (MPSs) constitute promising tools for evalua
Externí odkaz:
https://doaj.org/article/f3d6e51115fc431c979b3b6a3eb9921c
Publikováno v:
Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-10 (2021)
Abstract Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiation. Recent progress in this res
Externí odkaz:
https://doaj.org/article/2d24d0ea6c9d4d12bccda39aaf9b3953
Autor:
Nobuaki Shiraki, Shoen Kume
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 1, Pp 20-21 (2020)
Externí odkaz:
https://doaj.org/article/11c2a8b124874cce8d53c32709fa68f7
Autor:
Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Publikováno v:
Biology Open, Vol 8, Iss 7 (2019)
Differentiation of stem cells to hepatocytes provides an unlimited supply of human hepatocytes and therefore has been vigorously studied. However, to date, the stem cell-derived hepatocytes were suggested to be of immature features. To obtain matured
Externí odkaz:
https://doaj.org/article/0c22b2ec0c5f4e329edacc35f03e5a7c