Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Noboru Takasugi"'
Publikováno v:
Differentiation. 118:4-23
In the early 1960's, at Professor Bern's laboratory, University of California, Berkeley) in the US, Takasugi discovered ovary-independent, persistent vaginal changes in mice exposed neonatally to estrogen, which resulted in vaginal cancer later in li
Publikováno v:
Reproductive Toxicology. 86:56-61
In female mice, the Müllerian duct develops into the oviduct, uterus and vagina. The fate of epithelia is determined by factors secreted from the mesenchyme. Retinoic acid (RA) and its receptors are present in the mesenchyme of cranial Müllerian du
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 86:273-283
In male offspring of mice given a continuous intravenous infusion of 24 IU/day hCG from days 15 to 19 of gestation (hCG-primed mice), the number of Leydig cells/testis at 15 days of age was similar to the value at 10 days, whereas the cells were decr
Autor:
Hiroaki Okamura, Shinji Hayashi, Akihiro Chiba, Yasuhiko Ohta, Noboru Takasugi, Taisen Iguchi, Tomomi Sato
Publikováno v:
Reproductive Toxicology. 8:145-153
Estrogen receptor (ER) and ER mRNA expression and cell division induced by neonatal diethylstilbestrol (DES) exposure in male C57BL/Tw mouse genital organs were studied using immunohistochemistry, in situ hybridization, and cell counting at metaphase
Publikováno v:
Cancer Letters. 58:167-175
Pregnant ICR/JCL mice were given 4 daily subcutaneous injections of 0.2-2000 micrograms diethylstilbestrol (DES) starting on day 15 of gestation. Offspring of mothers given DES were killed at 1-10 days of age and examined for nodules of enlarged poly
Publikováno v:
Cells Tissues Organs. 139:201-208
The os penis of male C57BL/Tw mice given 5 daily injections of 100 µg tamoxifen (Tx) starting on the day of birth (day 0) was examined at ages of 5–60 days; the bones of males given Tx injections for 5 days starting at 0–10 days and of those giv
Publikováno v:
The Journal of endocrinology. 128(3)
The role of 5α-dihydrotestosterone (DHT) in the development of the genital organs and in the differentiation of the genital tract into prostate, coagulating gland (CG), bulbo-urethral gland (BUG) and seminal vesicle (SV) in male mice exposed prenata
Publikováno v:
Biology of Reproduction. 39:689-697
Female C57BL/Tw mice were given 5 daily injections of 20 l.Lg testosterone (T), 100 �.tg 4-hydroxy-4-androstene-3, I 7-dione (4-HA), 100 i.tg 6-methylene-4-pregnene-3, 20-dione (6-MP), 4-HA + 6-MP, T + 4-HA, T + 6-MP, and T + 4-HA + 6-MP starting o
Publikováno v:
Cells Tissues Organs. 127:110-114
A high incidence of vaginal adenosis-like lesions (ADL, 67%) was found in 30-day-old offspring of ICR/JCLmice given 4 daily subcutaneous injections of 2,000 µg diethylstilbestrol (DES) on days 15–18 of gestation. The prenatally DES-exposed mice an
Publikováno v:
Journal of Experimental Zoology. 225:99-105
In adult mice, neonatal injections of estrogen induce persistent, estrogen-independent cornification of the vaginal epithelium. Since the occurrence of nodules composed of affected epithelial cells (B cells) is a prodromic phenomenon of the irreversi