Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Noboru Ohsawa"'
Autor:
Shisako Shoji, Yutaka Muto, Mariko Ikeda, Fahu He, Kengo Tsuda, Noboru Ohsawa, Ryogo Akasaka, Takaho Terada, Motoaki Wakiyama, Mikako Shirouzu, Shigeyuki Yokoyama
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 689-703 (2014)
Anaphase-promoting complex or cyclosome (APC/C) is a multisubunit ubiquitin ligase E3 that targets cell-cycle regulators. Cdc20 is required for full activation of APC/C in M phase, and mediates substrate recognition. In vertebrates, Emi2/Erp1/FBXO43
Externí odkaz:
https://doaj.org/article/eebb99b88a1e49e6b0d411a7e38da7e5
Autor:
Suhaila Rahman, Ichiro Yamato, Shinya Saijo, Kenji Mizutani, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Takeshi Murata
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55704 (2013)
Peripheral stalk subunits of eukaryotic or mammalian vacuolar ATPases (V-ATPases) play key roles in regulating its assembly and disassembly. In a previous study, we purified several subunits and their isoforms of the peripheral stalk region of Homo s
Externí odkaz:
https://doaj.org/article/c540dc9b071547f798fa61cc56b570e2
Autor:
Md Jahangir Alam, Satoshi Arai, Shinya Saijo, Kano Suzuki, Kenji Mizutani, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Yoshimi Kakinuma, Ichiro Yamato, Takeshi Murata
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74291 (2013)
Vacuolar ATPases (V-ATPases) function as proton pumps in various cellular membrane systems. The hydrophilic V1 portion of the V-ATPase is a rotary motor, in which a central-axis DF complex rotates inside a hexagonally arranged catalytic A3B3 complex
Externí odkaz:
https://doaj.org/article/7ce6aa0c250c47519ec4ac08b05364f9
Autor:
Dr. Naomi Ohbayashi, Dr. Kazutaka Murayama, Miyuki Kato‐Murayama, Dr. Mutsuko Kukimoto‐Niino, Dr. Tamami Uejima, Dr. Takayoshi Matsuda, Dr. Noboru Ohsawa, Prof. Shigeyuki Yokoyama, Prof. Hiroshi Nojima, Dr. Mikako Shirouzu
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 713-719 (2018)
Abstract Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To rev
Externí odkaz:
https://doaj.org/article/1792a4ab9ff142d693f1b4b82f51f702
Autor:
Miyuki Kato-Murayama, Tamami Uejima, Naomi Ohbayashi, Hiroshi Nojima, Mutsuko Kukimoto-Niino, Shigeyuki Yokoyoma, Noboru Ohsawa, Kazutaka Murayama, Mikako Shirouzu, Takayoshi Matsuda
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 713-719 (2018)
ChemistryOpen
ChemistryOpen
Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To reveal the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2272832e711352642fc0dcbcd43db963
https://doaj.org/article/1792a4ab9ff142d693f1b4b82f51f702
https://doaj.org/article/1792a4ab9ff142d693f1b4b82f51f702
Autor:
Seiji Miyauchi, Mikako Shirouzu, Tomomi Kimura-Someya, Noboru Ohsawa, Takashi Kikukawa, Shigeyuki Yokoyama, Keisuke Ohkawa, Makoto Demura, Naoki Kamo, Kazumi Shimono, Toshifumi Nara, Jun Tamogami
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 183:35-45
Acetabularia rhodopsin II (ARII or Ace2), an outward light-driven algal proton pump found in the giant unicellular marine alga Acetabularia acetabulum, has a unique property in the cytoplasmic (CP) side of its channel. The X-ray crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367f4d26e85f3a5db6ac372540bcb43a
https://doi.org/10.1016/j.jphotobiol.2018.04.012
https://doi.org/10.1016/j.jphotobiol.2018.04.012
Autor:
Roman Belle, Kazuharu Hanada, Kosuke Nishio, Noboru Ohsawa, Hiroaki Suga, Takayuki Katoh, Akane Kawamura, Mikako Shirouzu, Toru Sengoku, Shigeyuki Yokoyama
Publikováno v:
ChemBioChem
The ten-eleven translocation (TET) protein family, consisting of three isoforms (TET1/2/3), have been found in mammalian cells and have a crucial role in 5-methylcytosine demethylation in genomic DNA through the catalysis of oxidation reactions assis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfef23544b0eb4396de23046d4e39f0b
https://doi.org/10.1002/cbic.201800047
https://doi.org/10.1002/cbic.201800047
Publikováno v:
Biochemical Journal
Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP or BRAP2). The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a5c8acf20ada305e751f74acdb1334
https://doi.org/10.1042/bcj20161104
https://doi.org/10.1042/bcj20161104
Autor:
Takaho Terada, Fumitaka Oyama, Haruko Miyazaki, Shun-ichi Sekine, Shisako Shoji, Nobuyuki Nukina, Mikako Shirouzu, Hideaki Shimizu, Yoshiko Ishizuka-Katsura, Shigeyuki Yokoyama, Asako Tosaki, Noboru Ohsawa
Publikováno v:
The Journal of Biological Chemistry
Voltage-gated sodium channels (VGSCs) are transmembrane proteins required for the generation of action potentials in excitable cells and essential for propagating electrical impulses along nerve cells. VGSCs are complexes of a pore-forming α subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42125e3af4ed36b9158f4800f7304fef
https://doi.org/10.1074/jbc.m117.786509
https://doi.org/10.1074/jbc.m117.786509
Autor:
Keiko Honda, Noboru Ohsawa, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Kengo Tsuda, Kentaro Ihara, Mikako Shirouzu
Publikováno v:
Structure (London, England : 1993). 27(5)
The Dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors activates the Rho family GTPases Rac and/or Cdc42 through DOCK homology region (DHR)- 2. Previous structural analyses of the DHR-2 domains of DOCK2 and DOCK9 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e91adbd28f63ea2b2c9ac48d1b3f4e9
https://pubmed.ncbi.nlm.nih.gov/30853411
https://pubmed.ncbi.nlm.nih.gov/30853411