Výsledky vyhledávání - "Noboru Nakashima"

Exploratory Trial of Intranasal Administration of Glucagon-Like Peptide-1 in Japanese Patients With Type 2 Diabetes

Autor: Wakaba Tsuchimochi, Masanari Mizuta, Hiroaki Ueno, Noboru Nakashima, Kenji Noma, Mitsuteru Fujihara, Masamitsu Nakazato, Tomomi Shiiya

Publikováno v: Diabetes Care. 37:2024-2027

OBJECTIVE This study aimed to assess the efficacy and safety of our newly developed nasal glucagon-like peptide-1 (GLP-1) compound and injector. RESEARCH DESIGN AND METHODS Twenty-six patients with type 2 diabetes were enrolled in this double-blind p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42be8a431c3b8cb19864b6287cca26c7
https://doi.org/10.2337/dc13-0690

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The Essential Amino Acid Domains in Salivary Peptide P-C That Potentiate Glucose-Induced Insulin Release and Inhibit Arginine-Induced Glucagon Release from Perfused Rat Pancreas

Autor: Masayasu Kimura, Noboru Nakashima, Ikuko Kimura

Publikováno v: Japanese Journal of Pharmacology. 67:79-82

The amino acid domains in salivary peptide P-C (1-44 peptide fragments, P-C) that are essential to potentiate insulin release and inhibit glucagon release were investigated using isolated perfused rat pancreas. P-C significantly potentiated not only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5203d2b52e6d2b288da7f8aaa8fecb
https://doi.org/10.1254/jjp.67.79

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Potentiating Effects on Pilocarpine-Induced Saliva Secretion, by Extracts and N-Containing Sugars Derived from Mulberry Leaves, in Streptozocin-Diabetic Mice

Autor: Naoki Asano, Ikuko Kimura, Masayasu Kimura, Fu-jun Chen, Sakuji Koya, Noboru Nakashima

Publikováno v: Biological and Pharmaceutical Bulletin. 18:1676-1680

The effects of hot water extracts and six compounds of N-containing sugars, 1-deoxynojirimycin (DNJ), N-methyl-DNJ (N-Me-DNJ), 2-O-alpha-D-galactopyranosyl-DNJ (GAL-DNJ), fagomine, 1,4-dideoxy-1,4-imino-D-arabinitol (DAB), and 1,2 alpha,3 beta,4 alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b3f0b5bc1558d9d932f4d1ced16634
https://doi.org/10.1248/bpb.18.1676

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Salivary Peptide P-C Potentiates Insulin Release and Inhibits Glucagon Release from Isolated Perfused Pancreas of the Diabetic GK Rat

Autor: Noboru Nakashima, Masayasu Kimura, Ikuko Kimura

Publikováno v: Japanese Journal of Pharmacology. 67:15-20

We investigated the effects of the salivary peptide P-C (P-C), a saliva-derived peptide, on glucose (8.3 mM)- and arginine (10 mM)-induced insulin release and arginine (10 mM)-induced glucagon release using the perfused pancreas of spontaneously diab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882229d1e3f77998b8f557432e147760
https://doi.org/10.1254/jjp.67.15

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Readability of Characters on Display Faceplates in Terms of Human Sensation

Autor: Hiroaki Ikeda, Noboru Nakashima, Tetsuya Muraoka

Publikováno v: IAS

Readability tests were carried out for three types of displays; a TFT-LCD with backlight of white LED matrices, a TFT-LCD with backlight of two-row cold cathode fluorescent lamps (CCFLs), and a CRT. Readability of the TFT-LCD with backlight of white

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bc2cba54f54ff0d21d392e64f957a7e
https://doi.org/10.1109/ias.2009.5324830

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The antihyperglycaemic blend effect of traditional chinese medicine byakko-ka-ninjin-to on alloxan and diabetic KK-CA(y) mice

Autor: Noboru Nakashima, Masayasu Kimura, Chen Fu-jun, Yoshitaka Sugihara, Ikuko Kimura

Publikováno v: Phytotherapy research : PTR. 13(6)

The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko-ka-ninjin-to (BN; consisted of five crude drugs, ginseng, anemarrhena,-licorice, gypsum and rice) was investigated using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f99ba55581c77c03dde1b7c4ec931a
https://pubmed.ncbi.nlm.nih.gov/10479758

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[Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice]

Autor: Masayasu Kimura, Ikuko Kimura, Fu-jun Chen, Noboru Nakashima

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 115(6)

Averaged blood glucose levels were 400 mg/dl in nonfasted mice, and 250 mg/dl in fasted mice in 4 weeks after injection with streptozotocin (STZ, 150 mg/kg, i.v.). These mice were used for experiments. Hypoglycemic effects of hot water extracts (W) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90daa6469b7f669d614eec184eefd939
https://pubmed.ncbi.nlm.nih.gov/7666358

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Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice

Autor: Ikuko Kimura, Masayasu Kimura, Noboru Nakashima, Hiromichi Matsuura

Publikováno v: Journal of natural products. 56(3)

A hot-H2O extract of rhizomes of Anemarrhena asphodeloides, the Japanese sino-medicine "chimo," lowered the blood glucose level in alloxan-diabetic mice. Hypoglycemic activity-guided fractionation isolated a new glycoside, pseudoprototimosaponin AIII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b92fbd2808e184773781cee381baa7b
https://pubmed.ncbi.nlm.nih.gov/8482946

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