Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Noboru Mizushima"'
Autor:
Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto, Noboru Mizushima
Publikováno v:
eLife, Vol 12 (2024)
During macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the late recruitment of the autophagosomal SNARE synt
Externí odkaz:
https://doaj.org/article/ce4db38e03334ce29e4228c492ac1adb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The formation of autophagosomes involves dynamic morphological changes of a phagophore from a flat membrane cisterna into a cup-shaped intermediate and a spherical autophagosome. However, the physical mechanism behind these morphological cha
Externí odkaz:
https://doaj.org/article/c41a3c8c3e29466aa516f903c043e45e
Autor:
Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson, David N. Zacks
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging
Externí odkaz:
https://doaj.org/article/061946d58aef4da69c2648d6e73ee4f8
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
The endoplasmic reticulum (ER) is an organelle that regulates several vital processes necessary to maintain the health of eukaryotic cells. Protein quality control systems selectively remove abnormal ER luminal proteins to maintain ER function. In ad
Externí odkaz:
https://doaj.org/article/cd18cc6751c64e46b86600e33ea3e029
Autor:
Jun-ichi Sakamaki, Noboru Mizushima
Publikováno v:
Cell Structure and Function, Vol 48, Iss 1, Pp 99-112 (2023)
Protein–lipid conjugation is a widespread modification involved in many biological processes. Various lipids, including fatty acids, isoprenoids, sterols, glycosylphosphatidylinositol, sphingolipids, and phospholipids, are covalently linked with pr
Externí odkaz:
https://doaj.org/article/c24b889e0438407d8e92651d487a33a4
Publikováno v:
Cell Structure and Function, Vol 47, Iss 2, Pp 89-99 (2022)
In macroautophagy, disk-shaped double-membrane structures called phagophores elongate to form cup-shaped structures, becoming autophagosomes upon closure. These autophagosomes then fuse with lysosomes to become autolysosomes and degrade engulfed mate
Externí odkaz:
https://doaj.org/article/d21922effbf64de196871b111f7de41e
Autor:
Jun-ichi Sakamaki, Noboru Mizushima
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101935- (2023)
Summary: Ubiquitin is covalently conjugated to phospholipids as well as proteins; however, ubiquitinated phospholipids are less abundant than free ubiquitin and ubiquitinated proteins. Here, we describe protocols to purify ubiquitinated phospholipids
Externí odkaz:
https://doaj.org/article/76a18f74f28f4e31a35ccab5a87667df
Publikováno v:
eLife, Vol 11 (2022)
Monitoring autophagic flux is necessary for most autophagy studies. The autophagic flux assays currently available for mammalian cells are generally complicated and do not yield highly quantitative results. Yeast autophagic flux is routinely monitore
Externí odkaz:
https://doaj.org/article/b99aceaeea6b44149da836e6a3a8a506
Autor:
Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic
Externí odkaz:
https://doaj.org/article/75e721e981164b0eac18bb692e449bb8
Autor:
Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon-Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the exp
Externí odkaz:
https://doaj.org/article/51a6699afdbe409189590eaa1356ad95