Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Noboru Chida"'
Autor:
Misato Ito, Shunji Yamazaki, Kaoru Yamagami, Masako Kuno, Yoshiaki Morita, Kenji Okuma, Koji Nakamura, Noboru Chida, Masamichi Inami, Takayuki Inoue, Shohei Shirakami, Yasuyuki Higashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 25-33 (2017)
The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several o
Externí odkaz:
https://doaj.org/article/f4e9fbfdb61f4dfcbfd9963e6911a4cf
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5499-5509
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and is an attractive target for the treatment of T cell-mediated diseases such as transplant rejection and autoimmune disease. To identify PKCθ inhibitors, we focused on the 2,
Autor:
Shohei Shirakami, Kenji Okuma, Yoshiaki Morita, Takayuki Inoue, Misato Ito, Masako Kuno, Shunji Yamazaki, Masamichi Inami, Yasuyuki Higashi, Kaoru Yamagami, Noboru Chida, Koji Nakamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 25-33 (2017)
The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several o
Publikováno v:
Bioorganicmedicinal chemistry. 27(5)
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. PKCθ inhibitors have emerged as effective immunomodulative age
Autor:
Tatsuaki Morokata, Shinsuke Oshima, Koji Nakamura, Masashi Maeda, Hidehiko Fukahori, Susumu Tsujimoto, Tomoko Kawashima, Jun Hirose, Mamoru Tasaki, Noboru Chida, Takahisa Noto, Yasuyuki Higashi
Publikováno v:
International Immunopharmacology. 27:232-237
Selective inhibition of protein kinase Cθ (PKCθ) may be useful in inducing T cell-specific immunosuppression with a reduced rate of side effects. To our knowledge, however, no reports have been published regarding the selective inhibition of PKCθ
Autor:
Shigeki Kunikawa, Akira Tanaka, Fumiyuki Shirai, Koichiro Mukoyoshi, Hiroaki Tominaga, Mamoru Tasaki, Shinya Nagashima, Noboru Chida
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3269-3277
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. Here, a series of 2,4-diamino-5-fluoropyrimidine derivatives we
Autor:
Noboru Chida, Yasuyuki Higashi, Takeshi Ishikawa, Hideaki Matsuoka, Keiko Suzuki, Akira Tanaka, Masashi Maeda, Mamoru Tasaki, Tomoko Kawashima, Hidehiko Fukahori
Publikováno v:
European Journal of Pharmacology. 745:217-222
T cell-mediated immunity is central to the pathogenesis of autoimmune diseases, and is a target in the development of alternative therapeutic strategies with reduced adverse effects on other cell types and organs. Protein kinase C (PKC) is a family o
Autor:
Keita Arakawa, Kazunari Nakao, Shoji Furusako, Noboru Chida, Shunsuke Maehara, Kotaro Hoshida, Hiroshi Nagasue
Publikováno v:
European journal of pharmacology. 811
Recently, we identified a novel phosphodiesterase 2A (PDE2A) inhibitor, PDM-631 ((S)-3-cyclopropyl-6-methyl-1-(1-(4-(trifluoromethoxy)phenyl)propan-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one). PDM-631 showed potent inhibitory activities for
Autor:
Yuji Sudo, Shijie Qi, Jun Ouyang, Xiaochun Zhang, Kouichi Tamura, Pierre Daloze, Anlun Ma, Noboru Chida, Huifang Chen, Wenlei Jiang, Dasheng Xu
Publikováno v:
Transplantation. 79:1386-1392
BACKGROUND Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS). Therefore, continuous inhibition of iNOS may prevent early graft dys
Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor
Autor:
Kouichi Tamura, Yuji Sudo, Seitaro Mutoh, Noboru Chida, Takehiko Ohkawa, Yoshimi Hirasawa, Yoshinori Ishii
Publikováno v:
European Journal of Pharmacology. 509:71-76
In this study, we examined effects of a newly synthesized chemical compound, FR260330, (2E)-3-(4-chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridinylmethyl)ethyl]acrylamide on n