MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2D ^Low T cells.

Autor: Toyoda H; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan.; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, 142-8555, Japan., Kuramasu A; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan., Hosonuma M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan., Murayama M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan.; Department of Otorhinolaryngology, Showa University School of Medicine, Tokyo, 142-8555, Japan., Narikawa Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan.; Department of Otorhinolaryngology, Showa University School of Medicine, Tokyo, 142-8555, Japan., Isobe J; Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Tokyo, 142-8555, Japan., Baba Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Tajima K; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Kanagawa, 259-1193, Japan., Funayama E; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan.; Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, 142-8555, Japan., Shida M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan., Maruyama Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan., Sasaki A; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan.; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan., Hirasawa Y; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Tsurui T; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Ariizumi H; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Ishiguro T; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Suzuki R; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Kobayashi S; Department of Otorhinolaryngology, Showa University School of Medicine, Tokyo, 142-8555, Japan., Horiike A; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Hida N; Division of Clinical Pharmacology, Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Division of Clinical Research and Development, Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo, 142-8555, Japan., Sambe T; Division of Clinical Research and Development, Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo, 142-8555, Japan., Nobe K; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan.; Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, 142-8555, Japan., Wada S; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, 157-8577, Japan., Kobayashi H; Department of Otorhinolaryngology, Showa University School of Medicine, Tokyo, 142-8555, Japan., Tsuji M; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan., Kobayashi S; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, 157-8577, Japan., Tsunoda T; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan., Kudo Y; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, 142-8555, Japan., Kiuchi Y; Department of Pharmacology, Showa University School of Medicine, Tokyo, 142-8555, Japan.; Pharmacological Research Center, Showa University, Tokyo, 142-8555, Japan., Yoshimura K; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kita-karasuyama, Setagaya-ku, Tokyo, 157-8577, Japan. kyoshim1@med.showa-u.ac.jp.; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan. kyoshim1@med.showa-u.ac.jp.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 08; Vol. 14 (1), pp. 23401. Date of Electronic Publication: 2024 Oct 08.

Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis.

Autor: Yamaguchi T; Department of Pharmacology, Showa University Graduate School of Pharmacy.; Pharmacological Research Center, Showa University., Shibata K; Department of Pharmacology, Showa University Graduate School of Pharmacy.; Pharmacological Research Center, Showa University., Hasumi K; Department of Applied Biological Science, Tokyo University of Agriculture and Technology., Nobe K; Department of Pharmacology, Showa University Graduate School of Pharmacy.; Pharmacological Research Center, Showa University.

Publikováno v: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2024; Vol. 47 (2), pp. 434-442.

SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis.

Autor: Terasaki M; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan., Shibata K; Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Mori Y; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Anti-Glycation Research Section, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan., Saito T; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan., Matsui T; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan., Ohara M; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan., Fukui T; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan., Hasumi K; TMS Co., Ltd., KeioFuchu1chome Bldg. 11F, 1-9 Fuchucho, Fuchu-shi, Tokyo 183-0055, Japan.; Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Fuchu-shi, Tokyo 183-8509, Japan., Higashimoto Y; Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan., Nobe K; Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Yamagishi SI; Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1-5-8 Shinagawa, Tokyo 142-8666, Japan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 30; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 30.

Aqueous electrodeposition of iron group–vanadium binary alloys

Autor: Yoo, B.Y., Schwartz, M., Nobe, K. ^*

Publikováno v: In Electrochimica Acta 2005 50(22):4335-4343

SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment.

Autor: Shinouchi R; Division of Pharmacology, Department of Pharmacology, Toxicology & Therapeutics, School of Pharmacy, Pharmacology Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Shibata K; Division of Pharmacology, Department of Pharmacology, Toxicology & Therapeutics, School of Pharmacy, Pharmacology Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Jono S; Division of Pharmacology, Department of Pharmacology, Toxicology & Therapeutics, School of Pharmacy, Pharmacology Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Hasumi K; Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu-shi, Tokyo 183-8509, Japan.; Division of Research and Development, TMS Co., Ltd., 1-23-3-501 Miyamachi, Fuchu-shi, Tokyo 183-0023, Japan., Nobe K; Division of Pharmacology, Department of Pharmacology, Toxicology & Therapeutics, School of Pharmacy, Pharmacology Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 06; Vol. 23 (9). Date of Electronic Publication: 2022 May 06.