Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Noayuki Miura"'
Autor:
Geraldine Vidhya Vijay, Na Zhao, Petra Den Hollander, Mike J. Toneff, Robiya Joseph, Mika Pietila, Joseph H. Taube, Tapasree R. Sarkar, Esmeralda Ramirez-Pena, Steven J. Werden, Maryam Shariati, Ruli Gao, Mary Sobieski, Clifford C. Stephan, Nathalie Sphyris, Noayuki Miura, Peter Davies, Jeffrey T. Chang, Rama Soundararajan, Jeffrey M. Rosen, Sendurai A. Mani
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TNBCs have reduced over
Externí odkaz:
https://doaj.org/article/94966eb44ff14ce28f1cf950c225b5fb
Autor:
Nathalie Sphyris, Mike J. Toneff, Jeffrey M. Rosen, Mary Sobieski, Maryam Shariati, Geraldine V. Vijay, Peter J.A. Davies, Noayuki Miura, Rama Soundararajan, Jeffrey T. Chang, Steven J. Werden, Esmeralda Ramirez-Peña, Na Zhao, Robiya Joseph, Tapasree Roy Sarkar, Sendurai A. Mani, Petra den Hollander, Joseph H. Taube, Mika Pietilä, Clifford Stephan, Ruli Gao
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TNBCs have reduced overall and d
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S6. KmPlots were generated for several major players of the Wnt signaling pathway using the KmPlotter. Of all the different players, GSK3β was the only gene, the upregulation of which significantly correlated with worse survival in TNBCs. (PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cee80f26d27f043ee1e34738bf5b53b
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S7. TCGA RPPA data was mined to compare the expression of GSK3β in TNBCs and other types of breast cancer. The analysis of these data revealed a significant increase in the expression of GSK3 in TNBCs as compared to the other types of breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d567ec7e4ecafc92c3fc8462a8beda
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S8. Claudin-low T11 cells were grown in ultra-low attachment plates in mammosphere media for 10 days in the presence of 3 GSK3β inhibitors. The numbers of mammospheres were counted and graphed (n = 3, p values were calculated using Student’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5251319b26567d1552cc5dd85c52490b
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S1. The IC50 of the 3 drugs were calculated for the 3 mesenchymal-like cell lines used in this study. (PDF 122â kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::747f1735c7086e00637724caa3fb13c1
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S3. GSK3β inhibitor, BIO, is one of the drugs that is capable of inhibiting the sphere forming ability of mesenchymal MDA-MB-231 cells. The drugs that were selected from the screen were used to treat the mammosphere assay. MDA MB 231 reporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296133292a7146ab8f68b1aaafae5c47
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S2. The drugs that were selected from the screen were validated using FACS. The MDA MB 231 reporter cells were treated with all the 11 drugs selected from the screen. Following treatment, the percentage of cells fluorescing red and green were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f65d275ab624d67452ff94e10f9082
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Figure S5. HMLE-vector and HMLE-Snail cells were treated with a dose range of the tested inhibitors, and viability was assessed by MTT assay. Of the drugs that were shortlisted from the screen, BIO was one of the drugs that could selectively inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc96426b9d3617520ea8c3e0f79a3db6
Autor:
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Sendurai Mani
Data S2. Summary of results from the high-throughput screen and the detailed red/green readout for each drug tested in the screen. (PDF 3424â kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc05508604a61038711153bf7763542f