Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Noam Shoresh"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011568 (2023)
Histone ChIP-seq is one of the primary methods for charting the cellular epigenomic landscape, the components of which play a critical regulatory role in gene expression. Analyzing the activity of regulatory elements across datasets and cell types ca
Externí odkaz:
https://doaj.org/article/9fea0f493fd54680be07e30ca209f7ab
Autor:
Nauman Javed, Yossi Farjoun, Tim J. Fennell, Charles B. Epstein, Bradley E. Bernstein, Noam Shoresh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Parallelized analysis in clinical genomics can lead to sample or data mislabelling, and could have serious downstream consequences. Here the authors present a tool to quantify sample genetic relatedness and detect such mistakes, and apply it to thous
Externí odkaz:
https://doaj.org/article/3aac3ad4af5c44bbbcff502de0819ea0
Autor:
J. Abraham Avelar-Rivas, Michelle Munguía-Figueroa, Alejandro Juárez-Reyes, Erika Garay, Sergio E. Campos, Noam Shoresh, Alexander DeLuna
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The chronological lifespan of budding yeast is a model of aging and age-related diseases. This paradigm has recently allowed genome-wide screening of genetic factors underlying post-mitotic viability in a simple unicellular system, which underscores
Externí odkaz:
https://doaj.org/article/7216fe8ccf1c4b33b3ea08bff5ff90ee
Autor:
Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Michael Schnall-Levin, Huidan Zhang, Anindita Basu, Bradley E Bernstein, David A Weitz
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0116328 (2015)
The importance of single-cell level data is increasingly appreciated, and significant advances in this direction have been made in recent years. Common to these technologies is the need to physically segregate individual cells into containers, such a
Externí odkaz:
https://doaj.org/article/d8770f8d4dff4c1586d2ffb8958f9d41
Autor:
Joel Rozowsky, Jiahao Gao, Beatrice Borsari, Yucheng T. Yang, Timur Galeev, Gamze Gürsoy, Charles B. Epstein, Kun Xiong, Jinrui Xu, Tianxiao Li, Jason Liu, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Maxwell S. Sun, James Wright, Justin Chang, Christopher J.F. Cameron, Noam Shoresh, Elizabeth Gaskell, Jorg Drenkow, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B. Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A. Davis, Daniel Farid, Nina P. Farrell, Idan Gabdank, Yoel Gofin, David U. Gorkin, Mengting Gu, Vivian Hecht, Benjamin C. Hitz, Robbyn Issner, Yunzhe Jiang, Melanie Kirsche, Xiangmeng Kong, Bonita R. Lam, Shantao Li, Bian Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Ran Meng, Jill E. Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E. Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M. Schreiber, Fritz J. Sedlazeck, Lei Hoon See, Rachel M. Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y. Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M. Mendenhall, William S. Noble, Zhiping Weng, Morgan E. Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M. Myers, Michael P. Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C. Schatz, Bradley E. Bernstein, Roderic Guigó, Thomas R. Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets from four don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464939170ba93b49ee4e474d325702f1
http://hdl.handle.net/10230/56942
http://hdl.handle.net/10230/56942
Autor:
Ann E Woolley, Scott Dryden-Peterson, Andy Kim, Sarah Naz-McLean, Christina Kelly, Hannah H Laibinis, Josephine Bagnall, Jonathan Livny, Peijun Ma, Marek Orzechowski, James Gomez, Noam Shoresh, Stacey Gabriel, Deborah T Hung, Lisa A Cosimi
Publikováno v:
Open Forum Infectious Diseases. 9
Background Unbiased assessment of the risks associated with acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to informing mitigation efforts during pandemics. The objective of our study was to understand the ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8414cd13652945310a086bb62bcf141
https://doi.org/10.1093/ofid/ofac505
https://doi.org/10.1093/ofid/ofac505
Autor:
Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J. Najm, Yuanyuan Zhang, Molly M. Moore, Vivian Hecht, Noam Shoresh, Bradley E. Bernstein
Publikováno v:
Nature genetics. 54(10)
Epigenomic maps identify gene regulatory elements by their chromatin state. However, prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate the interdependence of elements in a locus or capture single-molecule dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7e4e48c98f28cc86853d24490284ee
https://pubmed.ncbi.nlm.nih.gov/36195755
https://pubmed.ncbi.nlm.nih.gov/36195755
Autor:
Ann E. Woolley, Scott Dryden-Peterson, Andy Kim, Sarah Naz-McLean, Christina Kelly, Hannah H. Laibinis, Josephine Bagnall, Jonathan Livny, Peijun Ma, Marek Orzechowski, Noam Shoresh, Stacey Gabriel, Deborah T. Hung, Lisa A. Cosimi
Publikováno v:
medRxiv : the preprint server for health sciences.
ImportanceUnbiased assessment of risks associated with acquisition of SARS-CoV-2 is critical to informing mitigation efforts during pandemics.ObjectiveUnderstand risk factors for acquiring COVID-19 in a large, prospective cohort of adult residents re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699db2814e2543a69e77a1621f08c4b6
https://pubmed.ncbi.nlm.nih.gov/36381614
https://pubmed.ncbi.nlm.nih.gov/36381614
Autor:
Jonathan Livny, Lorrie L He, Kimberly A. Musser, Jamin Liu, Sophie S. Son, Jill Taylor, Peijun Ma, Milesh M. Patel, Roby P. Bhattacharyya, Lidan Wu, Rui Yang, Nirmalya Bandyopadhyay, Gustavo C. Cerqueira, Alejandro Pironti, Deborah T. Hung, Joseph M. Beechem, Lisa A. Cosimi, Jennifer Skerry, Rich Boykin, Robert F. Rudy, Rustem Khafizov, Ashlee M. Earl, Noam Shoresh, Virginia M. Pierce, Elizabeth Nazarian
Publikováno v:
Nature medicine
Multidrug resistant organisms are a serious threat to human health1,2. Fast, accurate antibiotic susceptibility testing (AST) is a critical need in addressing escalating antibiotic resistance, since delays in identifying multidrug resistant organisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92683042508f6b2d4c2eaaccb12887a0
http://europepmc.org/articles/PMC6930013
http://europepmc.org/articles/PMC6930013
Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
Autor:
Menno R. Vriens, Carlos Fernandez-del Castillo, Henry W. Long, Alba Font-Tello, Folkert H.M. Morsink, Mindy K. Graham, Paloma Cejas, Elfi B. Conemans, Koen M.A. Dreijerink, Vikram Deshpande, Holly Whitton, Christopher M. Heaphy, Michaela Bowden, Bradley E. Bernstein, Elizabeth Gaskell, Gerlof D. Valk, Yotam Drier, Lodewijk A.A. Brosens, Noam Shoresh, Annacarolina da Silva, Ewa Sicinska, Daniel C. Chung, Tomer Adar, Matthew H. Kulke, Cristina R. Ferrone, Charles B. Epstein, Ramesh A. Shivdasani
Publikováno v:
Nature medicine, 25(8), 1264-1269. Nature Publishing Group
Nature medicine
Nature Medicine, 25(8), 1264-1269. Nature Publishing Group
Nature medicine
Nature Medicine, 25(8), 1264-1269. Nature Publishing Group
Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are therefore considered ‘non-functional’1–3. As clinical behaviors vary widely and distant metastases are eventually lethal2,4, biological classifications might g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee06967b2a6cc703e33d66bc4d0a23d
https://doi.org/10.1038/s41591-019-0493-4
https://doi.org/10.1038/s41591-019-0493-4