Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Noam Prywes"'
Autor:
Chintan Soni, Noam Prywes, Matthew Hall, Malavika A. Nair, David F. Savage, Alanna Schepartz, Abhishek Chatterjee
Publikováno v:
ACS Central Science, Vol 10, Iss 6, Pp 1211-1220 (2024)
Externí odkaz:
https://doaj.org/article/ac17ef1c226146e99cb0921bd5b4b94a
Autor:
David Ding, Ada Y. Shaw, Sam Sinai, Nathan Rollins, Noam Prywes, David F. Savage, Michael T. Laub, Debora S. Marks
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Recent developments in protein design rely on large neural networks with up to 100s of millions of parameters, yet it is unclear which residue dependencies are critical for determining protein function. Here, we show that amino acid preferen
Externí odkaz:
https://doaj.org/article/5b7c1d3e4ad64c33ae3f2f2b7e909e0d
Autor:
Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G. Wernick, Alon Savidor, Uri Barenholz, Ron Milo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
An E. coli strain able to use CO2 fixation for sugar synthesis was previously generated by experimental evolution of an engineered strain. Here, Herz et al. show that specific mutations in five genes, encoding carbon metabolism enzymes or key regulat
Externí odkaz:
https://doaj.org/article/690248970691410cad98d1f38c3b74f9
Publikováno v:
eLife, Vol 5 (2016)
The nonenzymatic replication of RNA is a potential transitional stage between the prebiotic chemistry of nucleotide synthesis and the canonical RNA world in which RNA enzymes (ribozymes) catalyze replication of the RNA genomes of primordial cells. Ho
Externí odkaz:
https://doaj.org/article/0dea3afe82ff4d9eb55587753acbaae5
Autor:
Chunyu Zhao, Abdul Bhuiya, Jennifer A. Doudna, Melanie Ott, Emeric J Charles, Ming X. Tan, Brittney W. Thornton, Patrick D. Hsu, Amanda Mok, Arturo M. Escajeda, María Díaz de León Derby, Katherine S. Pollard, Daniel A. Fletcher, David F. Savage, G. Renuka Kumar, Noam Prywes, Tina Y. Liu, Dylan C. J. Smock, Shineui Kim, John J Desmarais, Eli J Dugan, Parinaz Fozouni, Sungmin Son, Liana F. Lareau, Neil A. Switz, Andrew R. Harris, Stephanie I. Stephens, Maxim Armstrong, Jeffrey Shu, Shrutee Jakhanwal, Anthony T. Iavarone, Roger McIntosh, Shreeya Agrawal, Gavin J. Knott
Publikováno v:
Nat Chem Biol
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided RNA recognition that triggers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785d1b2d3e9f64e47f040660076a9bd
https://europepmc.org/articles/PMC10184463/
https://europepmc.org/articles/PMC10184463/
Publikováno v:
The Journal of Organic Chemistry
The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. B
Autor:
Alison Fanton, Arturo M. Escajeda, Qi Dang, Sarah A. Stanley, Scott B. Biering, Jennifer A. Doudna, Maria Lukarska, David F. Savage, Shreeya Agrawal, Sita S. Chandrasekaran, Tina Y. Liu, Shin Kim, Dylan C. J. Smock, Gavin J. Knott, Ming X. Tan, Eli J Dugan, Eva Harris, Maxim Armstrong, María Díaz de León Derby, Patrick D. Hsu, Bérénice Charrez, Abdul Bhuiya, Daniel A. Fletcher, Noam Prywes, Andrew R. Harris, Roger McIntosh, Neil A. Switz, Sungmin Son, Amanda Mok, Erik Van Dis, Liana F. Lareau
SummaryRapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e1f77d8169d1823e572832e48428314
https://doi.org/10.1101/2020.12.14.20247874
https://doi.org/10.1101/2020.12.14.20247874
Autor:
Sita S, Chandrasekaran, Shreeya, Agrawal, Alison, Fanton, Aditya R, Jangid, Bérénice, Charrez, Arturo M, Escajeda, Sungmin, Son, Roger, Mcintosh, Huyen, Tran, Abdul, Bhuiya, María Díaz, de León Derby, Neil A, Switz, Maxim, Armstrong, Andrew R, Harris, Noam, Prywes, Maria, Lukarska, Scott B, Biering, Dylan C J, Smock, Amanda, Mok, Gavin J, Knott, Qi, Dang, Erik, Van Dis, Eli, Dugan, Shin, Kim, Tina Y, Liu, Erica A, Moehle, Katherine, Kogut, Brenda, Eskenazi, Eva, Harris, Sarah A, Stanley, Liana F, Lareau, Ming X, Tan, Daniel A, Fletcher, Jennifer A, Doudna, David F, Savage, Alisha, Baldwin
Publikováno v:
Nature biomedical engineering. 6(8)
Rapid nucleic acid testing is central to infectious disease surveillance. Here, we report an assay for rapid COVID-19 testing and its implementation in a prototype microfluidic device. The assay, which we named DISCoVER (for diagnostics with coronavi
Publikováno v:
Journal of the American Chemical Society
The chemical replication of RNA inside fatty acid vesicles is a plausible step in the emergence of cellular life. On the primitive Earth, simple protocells with the ability to import nucleotides and short oligomers from their environment could potent
Autor:
Amanda Mok, G. Renuka Kumar, Eli J Dugan, Noam Prywes, Stephanie I. Stephens, Shreeya Agrawal, María Díaz de León Derby, Liana F. Lareau, John J Desmarais, Brittney W. Thornton, David F. Savage, Andrew R. Harris, Katherine S. Pollard, Roger McIntosh, Patrick D. Hsu, Abdul Bhuiya, Emeric J Charles, Gavin J. Knott, Parinaz Fozouni, Anthony T. Iavarone, Melanie Ott, Shineui Kim, Sungmin Son, Ming X. Tan, Tina Y. Liu, Neil A. Switz, Chunyu Zhao, Shrutee Jakhanwal, Arturo M. Escajeda, Maxim Armstrong, Jeffrey Shu, Dylan C. J. Smock, Jennifer A. Doudna, Daniel A. Fletcher
Publikováno v:
Nature Chemical Biology. 17:1210-1210