Molecular mechanisms in colitis-associated colorectal cancer

Autor: Royce W. Zhou, Noam Harpaz, Steven H. Itzkowitz, Ramon E. Parsons

Publikováno v: Oncogenesis, Vol 12, Iss 1, Pp 1-11 (2023)

Abstract Sustained chronic inflammation of the large intestine leads to tissue damage and repair, which is associated with an increased incidence of colitis-associated colorectal cancer (CAC). The genetic makeup of CAC is somewhat similar to sporadic

Externí odkaz: https://doaj.org/article/59dbb7ebc30f486c87b7ca93aeb0d7d7

Impact of pathological response after neoadjuvant chemotherapy on adjuvant therapy decisions and patient outcomes in gastrointestinal cancers

Autor: Sheena Bhalla, Huili Zhu, Jung‐Yi Lin, Umut Özbek, Eric J. Wilck, Sanders Chang, Xiuxu Chen, Stephen Ward, Noam Harpaz, Alexandros D. Polydorides, William Miller, Maria Isabel Fiel, Ippolito Modica, Wen Fan, Nebras Zeizafoun, Celina Ang

Publikováno v: Cancer Reports, Vol 4, Iss 6, Pp n/a-n/a (2021)

Abstract Background Neoadjuvant chemotherapy (NAC) is frequently used in gastrointestinal cancers (GIC), and pathological, radiological, and tumor marker responses are assessed during and after NAC. Aim To evaluate the relationship between pathologic

Externí odkaz: https://doaj.org/article/1bdbe2c8a4f84eac9d655c81b2b4d045

Clinicopathological characterization of SMAD4-mutated intestinal adenocarcinomas: A case-control study.

Autor: Xiaoyan Liao, Yansheng Hao, Xiaofei Zhang, Stephen Ward, Jane Houldsworth, Alexandros D Polydorides, Noam Harpaz

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0212142 (2019)

The SMAD4 tumor suppressor gene product inhibits transforming growth factor-β-mediated signaling and is mutated in ~10% of colorectal carcinomas. The prognostic significance of SMAD4 mutations has been controversial. We studied the pathological and

Externí odkaz: https://doaj.org/article/74bd62529c294ef6bbccc1bc6072f088

Colorectal dysplasia in chronic inflammatory bowel disease: A contemporary consensus classification and interobserver study

Autor: Noam Harpaz, John R. Goldblum, Neil A. Shepherd, Robert H. Riddell, Carlos A. Rubio, Michael Vieth, Helen H. Wang, Robert D. Odze

Publikováno v: Human Pathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53394755ccc9bfd8111b162c80ebdfe1
https://doi.org/10.1016/j.humpath.2023.05.008

Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs

Autor: Shaomin Hu, Lindsay Alpert, Justin M.M. Cates, Raul S. Gonzalez, Rondell Graham, John R. Goldblum, Ahmed Bakhshwin, Sindhu Shetty, Hanlin L. Wang, Trang Lollie, Changqing Ma, Ayesha Siddique, Dipti M. Karamchandani, Fengming Chen, Rhonda K. Yantiss, Erika Hissong, Deyali Chatterjee, Shefali Chopra, Wei Chen, Jennifer Vazzano, Wei-Lien Wang, Di Ai, Jingmei Lin, Lan Zheng, Jessica L. Davis, Brian Brinkerhoff, Amanda Breitbarth, Michelle Yang, Sepideh Madahian, Nicole Panarelli, Kevin Kuan, Jonathan Pomper, Teri Longacre, Shyam Raghavan, Joseph Misdraji, Min Cui, Zhaohai Yang, Deepika Savant, Noam Harpaz, Xiuxu Chen, Murray Resnick, Elizabeth Yiru Wu, David Klimstra, Jinru Shia, Monika Vyas, Sanjay Kakar, Won-Tak Choi, Marie E. Robert, Hongjie Li, Michael Lee, Ian Clark, Yongchao Li, Wenqing Cao, Qing Chang, Mary P. Bronner, Zachary Dong, Wei Zhang, Darya Buehler, Paul E. Swanson, Jose G. Mantilla, Andrew M. Bellizzi, Michael Feely, Harry S. Cooper, Rajeswari Nagarathinam, Rish Pai, Suntrea Hammer, Mojgan Hosseini, JingJing Hu, Maria Westerhoff, Jerome Cheng, Diana Agostini-Vulaj, Gregory Lauwers, Masoumeh Ghayouri, Maryam K. Pezhouh, Jianying Zeng, Rong Xia, Feng Yin, Tao Zhang, Zu-hua Gao, Nadine Demko, Hannah H. Chen, Sanhong Yu, John Hart

Publikováno v: Modern Pathology. 35:554-563

Risk stratification of gastrointestinal stromal tumors (GISTs) is based on experience with tumors of the stomach, small bowel, and rectum, which are far more common than GISTs of other sites. In this study from 47 institutions, we analyzed GISTs of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37583e6e46184182eafafea943b56f80
https://doi.org/10.1038/s41379-021-00949-w