Výsledky vyhledávání - "Noam Greenspoon"

Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp

Autor: Ronen Alon, O Lider, Y A Mekori, Galina Kapustina, Noam Greenspoon, Rami Hershkoviz, R Hadari

Publikováno v: Clinical and Experimental Immunology. 95:270-276

SUMMARY The Arg-Gly-Asp (RGD) cell adhesion motif has been demonstrated in various studies to play a pivotal rote in leucocyte and platelet interactions with plasma and extracellular matrix (ECM) glycoproteins. The recognition the RGD sequence is med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840fd86af97c1996f145f1513e296702
https://doi.org/10.1111/j.1365-2249.1994.tb06522.x

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Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics

Autor: Lola Weiss, O Lider, Izhar Hardan, Ronen Alon, S. Slavin, R. Hershkoviz, Noam Greenspoon, Liora Cahalon, S. Reich

Publikováno v: International Journal of Cancer. 55:1023-1028

The spreading and colonization of tumor cells require their migration to metastatic sites via blood vessels. To penetrate blood-vessel walls, cells, including malignant ones, must recognize and associate with the sub-endothelium extracellular matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09245a36366a2fa8fd8d43fbcee4a5ea
https://doi.org/10.1002/ijc.2910550624

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Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence

Autor: Rami Hershkoviz, Galina Kapustina, Ronen Alon, Boris Shenkman, Gerard Marx, Noam Greenspoon, Ofer Lider, David Varon, Silvina Federman

Publikováno v: Biochemistry. 32:1001-1008

The pivotal role of the Arg-Gly-Asp (RGD) peptide motif in integrin-mediated cell adhesive interactions with extracellular matrix and plasma proteins stimulated the present design of nonpeptidic mimetics of this sequence. To probe the structural requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efcd621598659b77edaba1e0072baca
https://doi.org/10.1021/bi00055a002

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ChemInform Abstract: A Novel System Consisting of Rh-DuPHOS and Ionic Liquid for Asymmetric Hydrogenations

Autor: Adi Wolfson, Silvina Guernik, Moti Herskowitz, Noam Greenspoon, Shimona Geresh

Publikováno v: ChemInform. 33

The ionic liquid [bmim][PF6] was found to provide extra stability to the air-sensitive chiral catalyst Rh–MeDuPHOS in asymmetric hydrogenation of enamides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86a68193b5c59027371f2c2ca886dc5b
https://doi.org/10.1002/chin.200209039

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Interaction of Carbohydrates with Phosphatidylcholine Inverse Micelles

Autor: Noam Greenspoon, Ellen Wachtel, Silvina Federman

Publikováno v: Israel Journal of Chemistry. 32:113-119

Small angle X-ray scattering experiments indicate that egg phosphatidylcholine dissolved in benzene at a concentration of 12–50 mM organizes into approximately isometric inverse micelles with a size that depends upon the amount of water present. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ae94346a1fe2fed1765aa114beb6800
https://doi.org/10.1002/ijch.199200015

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A novel system consisting of Rh-DuPHOS and ionic liquid for asymmetric hydrogenations

Autor: Silvina Guernik, Noam Greenspoon, Shimona Geresh, Adi Wolfson, Moti Herskowitz

Publikováno v: Chemical communications (Cambridge, England). (22)

The ionic liquid [bmim][PF6] was found to provide extra stability to the air-sensitive chiral catalyst Rh–MeDuPHOS in asymmetric hydrogenation of enamides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa3fbfd620557e4afe77c830348656b
https://pubmed.ncbi.nlm.nih.gov/12240052

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Treatment of immune cell-mediated liver damage by nonpeptidic mimetics of the extracellular matrix-associated Arg-Gly-Asp epitope

Autor: Zamir Halpern, Rami Hershkoviz, Rafael Bruck, Ofer Lider, Husseim Aeed, Noam Greenspoon

Publikováno v: Journal of hepatology. 22(2)

The etiology of T-cell-mediated liver injury involves the migration of immune cells, notably CD4+ T lymphocytes, into liver tissues. This process is mediated primarily by integrin-recognition of the sub-endothelium basement membranes and the extracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea250a89ba2b829aaa6f5c4949e03ce
https://pubmed.ncbi.nlm.nih.gov/7540635

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Novel psi-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibronectin

Autor: Ofer Lider, Eytan Gershonov, Ronen Alon, Rami Hershkoviz, Noam Greenspoon, Barak Lavie

Publikováno v: International journal of peptide and protein research. 43(5)

The Leu-Asp-Val-(LDV)-containing amino acid sequence, derived from the alternatively spliced first connecting segment region of fibronectin (FN), was shown to be recognized primarily by the alpha 4 beta 1-integrin receptor expressed on the surface of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883572f48f1c98f170000e1ee0075ad0
https://pubmed.ncbi.nlm.nih.gov/7520889

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