Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Noam, Zilberberg"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Potassium K2P (“leak”) channels conduct current across the entire physiological voltage range and carry leak or “background” currents that are, in part, time- and voltage-independent. The activity of K2P channels affects numerous physiologica
Externí odkaz:
https://doaj.org/article/1590b5aecbbb4967a10f3f71ed0bf50a
Potassium K2P(‘leak’) channels conduct current across the entire physiological voltage range and carry leak or ‘background’ currents that are, in part, time- and voltage-independent. K2P2.1 channels (i.e., TREK-1, KCNK2) are highly expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ffe383745f206973fe85e03338b6ea
Publikováno v:
Molecular and cellular neurosciences. 105
Potassium K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1a48facd278fd646cea4b0756ef9d32
https://pubmed.ncbi.nlm.nih.gov/32320829
https://pubmed.ncbi.nlm.nih.gov/32320829
Autor:
Ohad S. Birk, Daniel Halperin, Max Drabkin, Rotem Kadir, Yuval Yogev, Noam Zilberberg, Yoram Etzion, Ohad Wormser, Sasson Menahem, Yonatan Perez, Amos Katz, Wesam Mulla
Publikováno v:
Circulation: Genomic and Precision Medicine. 11
Background: Paroxysmal atrial fibrillation (AF) can be caused by gain-of-function mutations in genes, encoding the cardiac potassium channel subunits KCNJ2 , KCNE1 , and KCNH2 that mediate the repolarizing potassium currents I k1 , I ks , and I kr ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fda3aa599f446453b745fa8b2410be
https://doi.org/10.1161/circgen.118.002293
https://doi.org/10.1161/circgen.118.002293
Publikováno v:
Molecular and Cellular Neuroscience. 40:382-389
Pain is a physiological state promoting protective responses to harmful episodes. However, pain can become pathophysiological and become a chronic disruptive condition, damaging quality of life. The mammalian K(2P)2.1 (KCNK2, TREK-1) channel, express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7d5e8fcf7579226d502ef04098c9ed
https://doi.org/10.1016/j.mcn.2008.12.004
https://doi.org/10.1016/j.mcn.2008.12.004
Publikováno v:
Journal of Biological Chemistry. 283:19448-19455
The mammalian K2P2.1 potassium channel (TREK-1, KCNK2) is highly expressed in excitable tissues, where it plays a key role in the cellular mechanisms of neuroprotection, anesthesia, pain perception, and depression. Here, we report that external acidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8dda6a81627f0cbb768a8b74dcb395e
https://doi.org/10.1074/jbc.m801273200
https://doi.org/10.1074/jbc.m801273200
Publikováno v:
FEBS Letters. 581:2478-2484
We have purified BoiTx1, the first toxin from the venom of the Israeli scorpion, Buthus occitanus israelis, and studied its activity and genomic organization. BoiTx1 is a 37 amino acid-long peptide contained six conserved cysteines, and is classified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4597f583563e5206b4d510df60c3104c
https://doi.org/10.1016/j.febslet.2007.04.065
https://doi.org/10.1016/j.febslet.2007.04.065
Autor:
Marcel Pelhate, Nicolas Gilles, Nitza Ilan, Dalia Gordon, Lior Cohen, Maria Stankiewicz, Michael Turkov, Noam Zilberberg, David Strugatsky, Michael Gurevitz
Publikováno v:
Biochemistry. 44:9179-9187
We isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus an extremely active anti-insect selective depressant toxin, Lqh-dprIT(3). Cloning of Lqh-dprIT(3) revealed a gene family encoding eight putative polypeptide variants (a-h) di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850e6338df94fcb2d7fedebeea94f630
https://doi.org/10.1021/bi050235t
https://doi.org/10.1021/bi050235t
Autor:
Noam Zilberberg, Roland G. Kallen, Michael Gurevitz, Nitza Ilan, Nicolas Gilles, Oren Froy, Lior Cohen, Daniel Urbach, Izhar Karbat, Morris Benveniste, Ariel Gaathon, Dalia Gordon
Publikováno v:
European Journal of Biochemistry. 270:2663-2670
Scorpion toxins that affect sodium channel (NaCh) gating in excitable cells are divided into alpha- and beta-classes. Whereas alpha-toxins have been found in scorpions throughout the world, anti-mammalian beta-toxins have been assigned, thus far, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a1333a03bf93985832e76ced4bc2fc2
https://doi.org/10.1046/j.1432-1033.2003.03643.x
https://doi.org/10.1046/j.1432-1033.2003.03643.x
Publikováno v:
Cell. 111:577-588
Proteins with dibasic retention motifs are subject to retrograde transport to endoplasmic reticulum (ER) by COPI-coated vesicles. As forward transport requires escape from ER retention, general release mechanisms have been expected. Here, KCNK3 potas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc99a62b323e9f775fd994cf60b1c4f
https://doi.org/10.1016/s0092-8674(02)01040-1
https://doi.org/10.1016/s0092-8674(02)01040-1