Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Noal Cohen"'
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f954d2982302b35c7516d54421fb833
https://doi.org/10.1021/jm1001919
https://doi.org/10.1021/jm1001919
Publikováno v:
The Journal of Organic Chemistry. 61:118-124
The 25-hydroxy and 1α,25-dihydroxy vitamin D3 metabolites are obtained by solvolytic rearrangements of the 1-desoxy and 1α-hydroxy cyclopropyl vinylogous alcohols 31 and 29, respectively, with simultaneous formation of the vitamin D structural trie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6d46ad9e9fec6f3deb8589ab86a0ca8
https://doi.org/10.1021/jo951229d
https://doi.org/10.1021/jo951229d
Autor:
Keith A. Yagaloff, Noal Cohen
Publikováno v:
Expert Opinion on Investigational Drugs. 3:13-22
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator derived from arachidonic acid via the 5-lipoxygenase pathway. It is a powerful chemoattractant and activator of neutrophils and exhibits effects on other cell types as well. This eicosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226b629ae8c3975ad3552bcad490842f
https://doi.org/10.1517/13543784.3.1.13
https://doi.org/10.1517/13543784.3.1.13
Publikováno v:
ChemInform. 23
1,25-Dihydroxycholecalciferol (23) was synthesized from A-ring precursor 18 and Windaus-Grundmann ketone 19 via cyclovitamin D 21. Key reactions include highly stereoselective (5 to 6) and stereospecific (13 to 14) cyclopropanations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ecf6b9573c8d7b52a9a6b2623aa2816
https://doi.org/10.1002/chin.199209138
https://doi.org/10.1002/chin.199209138
Autor:
Frederick Wong, David L. Coffen, Anthony M. Pico, Noal Cohen, Mark J. Sebastian, Rudolf Schmid
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c57847776e62b5d3e00e5100c4ace6
https://doi.org/10.1002/chin.199526259
https://doi.org/10.1002/chin.199526259
Publikováno v:
ChemInform. 27
The 25-hydroxy and 1α,25-dihydroxy vitamin D3 metabolites are obtained by solvolytic rearrangements of the 1-desoxy and 1α-hydroxy cyclopropyl vinylogous alcohols 31 and 29, respectively, with simultaneous formation of the vitamin D structural trie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4734e7aad72536335036e82ec8aff5
https://doi.org/10.1002/chin.199620211
https://doi.org/10.1002/chin.199620211
Publikováno v:
Tetrahedron Letters. 32:2343-2346
1,25-Dihydroxycholecalciferol (23) was synthesized from A-ring precursor 18 and Windaus-Grundmann ketone 19 via cyclovitamin D 21. Key reactions include highly stereoselective (5 to 6) and stereospecific (13 to 14) cyclopropanations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e74778c7edfde81bc4c71fdcae7805
https://doi.org/10.1016/s0040-4039(00)79919-9
https://doi.org/10.1016/s0040-4039(00)79919-9