Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Noah W Gray"'
Publikováno v:
PLoS Biology, Vol 5, Iss 7, p e189 (2007)
Cortical maps, consisting of orderly arrangements of functional columns, are a hallmark of the organization of the cerebral cortex. However, the microorganization of cortical maps at the level of single neurons is not known, mainly because of the lim
Externí odkaz:
https://doaj.org/article/db531cf69aa94e2596b68553192fac99
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e370 (2006)
Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their volumes are proportional to the area of the postsynaptic density (PSD) and synaptic strength. PSD-95 is an abundant multi-domain postsynaptic scaffolding protein t
Externí odkaz:
https://doaj.org/article/c3bfec44bd134b5191901387ade807a4
Autor:
Noah W. Gray, Zaza Khuchua, Richard L. Huganir, Karel Svoboda, Haining Zhong, Gek Ming Sia, Tianyi Mao, Takashi R. Sato
Publikováno v:
Neuron. 62:363-374
Protein kinase A (PKA) plays multiple roles in neurons. The localization and specificity of PKA are largely controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA in neurons, and the roles of specific AKAPs, are poorly unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0926d4ef41b5c0f4735222eda910f2
https://doi.org/10.1016/j.neuron.2009.03.013
https://doi.org/10.1016/j.neuron.2009.03.013
Publikováno v:
Journal of Biological Chemistry. 279:24612-24623
ALS2 is the gene mutated in a recessive juvenile form of amyotrophic lateral sclerosis (ALS2). ALS2 encodes a large protein termed alsin, which contains a number of predicted cell signaling and protein trafficking sequence motifs. To gain insight int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47d97eadc9a662834a076c180743ff8
https://doi.org/10.1074/jbc.m313504200
https://doi.org/10.1074/jbc.m313504200
Publikováno v:
Journal of Neurochemistry. 86:470-478
Amyloid-beta (Abeta) is the principal protein constituent of 'senile plaques' and is a suspected mediator in Alzheimer's disease (AD). Senile plaques also contain acetylcholinesterase (AChE; EC 3.1.1.7), which may have a role in promoting Alphabeta-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4ba2c20be31c0f52ee5afd71ee7a18
https://doi.org/10.1046/j.1471-4159.2003.01855.x
https://doi.org/10.1046/j.1471-4159.2003.01855.x
Autor:
Aimee E. Novelle, Noah W. Gray, Mark A. McNiven, Michael A. Cousin, Mark E. Graham, Karen J. Smillie, Nancy Sue, Jing Xue, Phillip J. Robinson
Publikováno v:
Xue, J, Graham, M E, Novelle, A E, Sue, N, Gray, N, McNiven, M A, Smillie, K J, Cousin, M A & Robinson, P J 2011, ' Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis ', Journal of Biological Chemistry, vol. 286, no. 35, pp. 30295-30303 . https://doi.org/10.1074/jbc.M111.273110
Depolarization of nerve terminals stimulates rapid dephosphorylation of two isoforms of dynamin I (dynI), mediated by the calcium-dependent phosphatase calcineurin (CaN). Dephosphorylation at the major phosphorylation sites Ser-774/778 promotes a dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c0b39dbd49be7baebd7cf75ff731ed
https://pubmed.ncbi.nlm.nih.gov/21730063
https://pubmed.ncbi.nlm.nih.gov/21730063
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(40)
Rett syndrome, an autism spectrum disorder with prominent motor and cognitive features, results from mutations in the gene for methyl-CpG-binding protein 2 (MeCP2). Here, to identify cortical circuit abnormalities that are specifically associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb77982fef204e36994ad69670c05e75
https://pubmed.ncbi.nlm.nih.gov/19812320
https://pubmed.ncbi.nlm.nih.gov/19812320
Autor:
Noah W. Gray, Emanuel E. Strehler, Sertac N. Kip, Richard J. Weinberg, Alain C. Burette, Ali Canbay
Spatial and temporal control of intracellular calcium signaling is essential for neuronal development and function. The termination of local Ca2+ signaling and the maintenance of basal Ca2+ levels require specific extrusion systems in the plasma memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29632945f607e4ea9f5adc529f70f5f6
Publikováno v:
Journal of cell science. 118(Pt 6)
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81bb2d5b4f66d149a9cee527fe609c7
https://pubmed.ncbi.nlm.nih.gov/15741233
https://pubmed.ncbi.nlm.nih.gov/15741233
Publikováno v:
Neuron. 48(5)
Inducible and reversible silencing of selected neurons in vivo is critical to understanding the structure and dynamics of brain circuits. We have developed Molecules for Inactivation of Synaptic Transmission (MISTs) that can be genetically targeted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba342456380059b5b8610b5a1d07174d
https://pubmed.ncbi.nlm.nih.gov/16337911
https://pubmed.ncbi.nlm.nih.gov/16337911