DNA unwinding by ring-shaped T4 helicase gp41 is hindered by tension on the occluded strand.

Autor: Noah Ribeck, Omar A Saleh

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79237 (2013)

The replicative helicase for bacteriophage T4 is gp41, which is a ring-shaped hexameric motor protein that achieves unwinding of dsDNA by translocating along one strand of ssDNA while forcing the opposite strand to the outside of the ring. While much

Externí odkaz: https://doaj.org/article/edd3a8447c95482a960746d0dd12e65b

Tempo and mode of genome evolution in a 50,000-generation experiment

Autor: Aurko Dasgupta, Richard E. Lenski, Jeffrey E. Barrick, Sébastien Wielgoss, Noah Ribeck, Claudine Médigue, Jeffrey L. Blanchard, Gabriel C. Wu, Stéphane Cruveiller, Daniel E. Deatherage, Dominique Schneider, Olivier Tenaillon

Publikováno v: Nature
Nature, Nature Publishing Group, 2016, 536 (7615), pp.165-170. ⟨10.1038/nature18959⟩
Nature, 2016, 536 (7615), pp.165-170. ⟨10.1038/nature18959⟩

Adaptation by natural selection depends on the rates, effects and interactions of many mutations, making it difficult to determine what proportion of mutations in an evolving lineage are beneficial. Here we analysed 264 complete genomes from 12 Esche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f1d4fdefb165159116692dad406134
https://hal.archives-ouvertes.fr/hal-01653393

Modeling and quantifying frequency-dependent fitness in microbial populations with cross-feeding interactions

Autor: Richard E. Lenski, Noah Ribeck

Coexistence of multiple populations by frequency-dependent selection is common in nature, and it often arises even in well-mixed experiments with microbes. If ecology is to be incorporated into models of population genetics, then it is important to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219a6eef19b194a661fa0a221484dc98

Long-term dynamics of adaptation in asexual populations

Autor: Noah Ribeck, Michael J. Wiser, Richard E. Lenski

Publikováno v: Science (New York, N.Y.). 342(6164)

Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal fitness remains the ultimate metric for interpreting these experiments, and the dynamics of fitn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276101a51338ae27e6d036785f1cf358
https://pubmed.ncbi.nlm.nih.gov/24231808

DnaB helicase activity is modulated by DNA geometry and force

Autor: Daniel L. Kaplan, Noah Ribeck, Omar A. Saleh, Irina Bruck

Publikováno v: Biophysical journal. 99(7)

The replicative helicase for Escherichia coli is DnaB, a hexameric, ring-shaped motor protein that encircles and translocates along ssDNA, unwinding dsDNA in advance of its motion. The microscopic mechanisms of DnaB are unknown; further, prior work h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90376f86b878df1c54065d990202d273
https://pubmed.ncbi.nlm.nih.gov/20923651